Abstract
Ginseng and its active ingredient ginsenosides are valued for their medicinal properties. More than 100 ginsenosides have been identified from the different parts of the plants in the genus Panax and during the processing of the plants. Ginsenosides can increase longevity, reduce blood pressure, alleviate diabetes and cardiovascular diseases, and inhibit cancers. Ginseng is widely used to prepare porridge, soup, and tea. Ginseng products range from neutraceuticals and cosmoceuticals to functional food. No adverse effects of consuming Panax ginseng or its extract were observed.
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References
Bu QT, Zhang WY, Chen QC, Zhang CZ, Gong XJ, Liu WC, Li W, Zheng YN (2012) Anti-diabetic effect of ginsenoside Rb(3) in alloxan-induced diabetic mice. Med Chem 8:934–941
Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP (2011) Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice. Am J Chin Med 39(4):779–788
Chen CF, Chiou WF, Zhang JT (2008) Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolius. Acta Pharmacol Sin 29:1103–1108
Chen HF, Wu LX, Li XF, Zhu YC, Wang WX, Xu CW, Huang ZZ, Du KQ (2019) Ginsenoside compound K inhibits growth of lung cancer cells via HIF-1alpha-mediated glucose metabolism. Cell Mol Biol (Noisy-le-Grand) 65:48–52
Chu S, Gu J, Feng L, Liu J, Zhang M, Jia X, Liu M, Yao D (2014) Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses. Int Immunopharmacol 19:317–326
Cui Y, Su Y, Deng L, Wang W (2018) Ginsenoside-Rg5 inhibits retinoblastoma proliferation and induces apoptosis through suppressing BCL2 expression. Chemotherapy 63:293–300
Ernst E (2010) Panax ginseng: An overview of the clinical evidence. J Ginseng Res 34:259–263
Fang F, Chen X, Huang T, Lue LF, Luddy JS, Yan SS (2012) Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochim Biophys Acta 1822:286–292
Fuzzati N (2004) Analysis methods of ginsenosides. J Chromatogr B Analyt Technol Biomed Life Sci 812:119–133
Gao Q, Zheng J (2018) Ginsenoside Rh2 inhibits prostate cancer cell growth through suppression of microRNA-4295 that activates CDKN1A. Cell Prolif 51:e12438
Gao Y, Chu S, Li J, Li J, Zhang Z, Xia C, Heng Y, Zhang M, Hu J, Wei G et al (2015) Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway. J Ethnopharmacol 173:231–240
Ge G, Yan Y, Cai H (2017) Ginsenoside Rh2 inhibited proliferation by inducing ROS mediated ER stress dependent apoptosis in lung cancer cells. Biol Pharm Bull 40:2117–2124
Guo Y, Yang T, Lu J, Li S, Wan L, Long D, Li Q, Feng L, Li Y (2011) Rb1 postconditioning attenuates liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway. Life Sci 88:598–605
Hwang E, Park S, Yin C, Kim H, Kim Y, Yi T (2017) Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin. J Ginseng Res 41(1):69–77
Joh EH, Lee IA, Jung IH, Kim DH (2011) Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation – the key step of inflammation. Biochem Pharmacol 82:278–286
Jovanovski E, Bateman EA, Bhardwaj J, Fairgrieve C, Mucalo I, Jenkins AL, Vuksan V (2014a) Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial. J Am Soc Hypertens 8:537–541
Jovanovski E, Peeva V, Sievenpiper JL, Jenkins AL, Desouza L, Rahelic D, Sung MK, Vuksan V (2014b) Modulation of endothelial function by Korean red ginseng (Panax ginseng C.A. Meyer) and its components in healthy individuals: a randomized controlled trial. Cardiovasc Ther 32:163–169
Jung JS, Kim DH, Kim HS (2010) Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem Biophys Res Commun 397:323–328
Kang T, Park H, Kim Y (2009) Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol 123(3):446–451
Kim TW, Joh EH, Kim B, Kim DH (2012) Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPS to toll-like receptor-4 on macrophages. Int Immunopharmacol 12:110–116
Kim DH, Chung JH, Yoon JS, Ha YM, Bae S, Lee EK, Jung KJ, Kim MS, Kim YJ, Kim MK et al (2013a) Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-kappaB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res 37:54–63
Kim EJ, Jung IH, Van Le TK, Jeong JJ, Kim NJ, Kim DH (2013b) Ginsenosides Rg5 and Rh3 protect scopolamine-induced memory deficits in mice. J Ethnopharmacol 146:294–299
Kim SS, Jang HJ, Oh MY, Eom DW, Kang KS, Kim YJ, Lee JH, Ham JY, Choi SY, Wee YM et al (2014) Ginsenoside Rg3 enhances islet cell function and attenuates apoptosis in mouse islets. Transplant Proc 46:1150–1155
Lee JG, Lee YY, Wu B, Kim SY, Lee YJ, Yun-Choi HS, Park JH (2010a) Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation. Pharmazie 65:520–522
Lee TK, O’Brien KF, Wang W, Johnke RM, Sheng C, Benhabib SM, Wang T, Allison RR (2010b) Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: a study of 40 cases. J Altern Complement Med 16:561–567
Lee IA, Hyam SR, Jang SE, Han MJ, Kim DH (2012) Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages. J Agric Food Chem 60:9595–9602
Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH (2013) Ginsenoside rg3 alleviates lipopolysaccharide-induced learning and memory impairments by anti-inflammatory activity in rats. Biomol Ther (Seoul) 21:381–390
Lee SY, Jeong JJ, Eun SH, Kim DH (2015) Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis. Eur J Pharmacol 762:333–343
Leung KW, Leung FP, Huang Y, Mak NK, Wong RN (2007) Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor. FEBS Lett 581:2423–2428
Li J, Zhong W, Wang W, Hu S, Yuan J, Zhang B, Hu T, Song G (2014a) Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-kappaB activation. PLoS One 9:e87810
Li JP, Gao Y, Chu SF, Zhang Z, Xia CY, Mou Z, Song XY, He WB, Guo XF, Chen NH (2014b) Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis. Acta Pharmacol Sin 35:1031–1044
Li LC, Piao HM, Zheng MY, Lin ZH, Choi YH, Yan GH (2015) Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor-kappaB activation in a murine model of asthma. Mol Med Rep 12:6946–6954
Liu Y, Fan D (2018) Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct 9:5513–5527
Liu DH, Chen YM, Liu Y, Hao BS, Zhou B, Wu L, Wang M, Chen L, Wu WK, Qian XX (2012) Ginsenoside Rb1 reverses H2O2-induced senescence in human umbilical endothelial cells: involvement of eNOS pathway. J Cardiovasc Pharmacol 59:222–230
Liu H, Zhao J, Fu R, Zhu C, Fan D (2019) The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS One 14:e0216759
Ma L, Liu H, Xie Z, Yang S, Xu W, Hou J, Yu B (2014) Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-kappaB pathway: a mouse cardiomyocyte model. PLoS One 9:e103628
Niki E, Yoshida Y, Saito Y, Noguchi N (2005) Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 338:668–676
Pan C, Huo Y, An X, Singh G, Chen M, Yang Z, Pu J, Li J (2012) Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vessel dilatation. Vasc Pharmacol 56:150–158
Park HM, Kim SJ, Mun AR, Go HK, Kim GB, Kim SZ, Jang SI, Lee SJ, Kim JS, Kang HS (2012) Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. J Ethnopharmacol 141:1071–1076
Park SJ, Lim KY, Noh JH, Jeong EU, Kim YS, Han BC, Moon KS (2013) Subacute oral toxicity study of Korean red ginseng extract in Sprague-Dawley Rats. Toxicology Research 29(4):285–292
Peng Y, Zhang R, Yang X, Zhang Z, Kang N, Bao L, Shen Y, Yan H, Zheng F (2019) Ginsenoside Rg3 suppresses the proliferation of prostate cancer cell line PC3 through ROS-induced cell cycle arrest. Oncol Lett 17:1139–1145
Rhee MY, Cho B, Kim KI, Kim J, Kim MK, Lee EK, Kim HJ, Kim CH (2014) Blood pressure lowering effect of Korea ginseng derived ginseol K-g1. Am J Chin Med 42:605–618
Shin BK, Kwon SW, Park JH (2015) Chemical diversity of ginseng saponins from Panax ginseng. J Ginseng Res 39:287–298
Siegel RK (1979) Ginseng abuse syndrome. Problems with the panacea. JAMA 241:1614–1615
Sun MY, Song YN, Zhang M, Zhang CY, Zhang LJ, Zhang H (2019) Ginsenoside Rg3 inhibits the migration and invasion of liver cancer cells by increasing the protein expression of ARHGAP9. Oncol Lett 17:965–973
Tao T, Chen F, Bo L, Xie Q, Yi W, Zou Y, Hu B, Li J, Deng X (2014) Ginsenoside Rg1 protects mouse liver against ischemia-reperfusion injury through anti-inflammatory and anti-apoptosis properties. J Surg Res 191:231–238
Wang W, Rayburn ER, Hao M, Zhao Y, Hill DL, Zhang R, Wang H (2008) Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate 68:809–819
Wang T, Yu X, Qu S, Xu H, Han B, Sui D (2010a) Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. Eur J Pharmacol 636:121–125
Wang T, Yu XF, Qu SC, Xu HL, Sui DY (2010b) Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation. Basic Clin Pharmacol Toxicol 107:685–689
Wang Y, Dong J, Liu P, Lau CW, Gao Z, Zhou D, Tang J, Ng CF, Huang Y (2014a) Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats. Br J Pharmacol 171:3171–3181
Wang Y, Liu Y, Zhang XY, Xu LH, Ouyang DY, Liu KP, Pan H, He J, He XH (2014b) Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-kappaB and PI3K/Akt/mTOR pathways. Int Immunopharmacol 23:77–84
Wei N, Zhang C, He H, Wang T, Liu Z, Liu G, Sun Z, Zhou Z, Bai C, Yuan D (2014) Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-kappaB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. J Pharm Pharmacol 66:1641–1651
Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, Li X (2007) Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int Immunopharmacol 7:313–320
Xie CL, Li JH, Wang WW, Zheng GQ, Wang LX (2015) Neuroprotective effect of ginsenoside-Rg1 on cerebral ischemia/reperfusion injury in rats by downregulating protease-activated receptor-1 expression. Life Sci 121:145–151
Xu Y, Lin L, Tang L, Zheng M, Ma Y, Huang L, Meng W, Wang W (2014) Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK. Am J Chin Med 42:799–816
Yang Y, Li X, Zhang L, Liu L, Jing G, Cai H (2015) Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARgamma/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury. Int J Clin Exp Pathol 8:2484–2494
Ye R, Kong X, Yang Q, Zhang Y, Han J, Zhao G (2011a) Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology 61:815–824
Ye R, Yang Q, Kong X, Han J, Zhang X, Zhang Y, Li P, Liu J, Shi M, Xiong L et al (2011b) Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats. Neurochem Int 58:391–398
Zheng H, Jeong Y, Song J, Ji GE (2011) Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice. Int Immunopharmacol 11:511–518
Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C (2005) Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg 41:861–868
Zhu J, Jiang Y, Wu L, Lu T, Xu G, Liu X (2012) Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia. Neuroscience 202:342–351
Zong Y, Ai QL, Zhong LM, Dai JN, Yang P, He Y, Sun J, Ling EA, Lu D (2012) Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-gamma1 signaling pathway in murine BV-2 microglial cells. Curr Med Chem 19:770–779
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Nagappan, T., Cheang, W.S. (2021). Ginsenosides in Diets. In: Xiao, J., Sarker, S.D., Asakawa, Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. https://doi.org/10.1007/978-981-15-4148-3_42
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DOI: https://doi.org/10.1007/978-981-15-4148-3_42
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