Abstract
The last century has witnessed unmatched advances in understanding of disease processes, surgical skills, and medical technology thereby enhancing our ability to add years to life. However, these advances have introduced newer subsets of problems; infectious complications related to therapeutic interventions being the most prominent amongst them. They affect both the developed and the developing countries and have a potential to prolong the morbidity and hospital stay, propagate antimicrobial resistance, affect the family economy adversely, and escalate the mortality figures. These nosocomial, hospital-acquired or health-care associated infections (HAI) are not present or incubating at the time of admission to the health-care facility (hospital or ICU). It is inherent in the definition of nosocomial infection that the patient was admitted for a reason other than the infection under consideration. Also included within the domain of nosocomial infections are those infections that were acquired during the ICU stay but presented after discharge of the patient and the occupational infections amongst the ICU staff (Benenson 1995). The incidence of nosocomial infections in the ICU patients is 5–10 times higher than that in the general hospital admissions; the toll is even higher for pediatric patients in view of their inherent susceptibility (immature immune system, lack of prior exposure to same or similar antigens, porosity of physical barriers to external invaders, presence of congenital or acquired immunodeficiency disorders, parenteral nutrition for prolonged periods and association with congenital anomalies) (Dasgupta et al. 2015). A study from Europe reported a 25 times higher incidence of nosocomial infections in the neonatal intensive care units as compared to the general children ward (Raymond and Aujard 2000).
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References
Ahirrao VS, Mauskar A, Ravi T. Incidence of nosocomial infection in the pediatric intensive care unit of a teaching hospital delivering tertiary level care. Int J Contemp Pediatr. 2017;4:332–5.
Alexander JW, Solomkin JS, Edwards MJ. Updated recommendations for control of surgical site infections. Ann Surg. 2011;253(6):1082–93.
American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171(4):388–416.
Anderson DJ, Kaye KS, Classen D, et al. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29(Suppl 1):S51–61.
Atilla A, Doganay Z, Kefeli CH, Demirag MD, Kilic S. Central line-associated blood stream infections: characteristics and risk factors for mortality over a 5.5-year period. Turk J Med Sci. 2017;47:646–52.
Banupriya B, Biswal N, Srinivasaraghavan R, Narayanan P, Mandal J. Probiotic prophylaxis to prevent ventilator associated pneumonia (VAP) in children on mechanical ventilation: an open-label randomized controlled trial. Intensive Care Med. 2015;41:677–85.
Baur D, Gladstone BP, Burkert F, Carrara E, Foschi F, Döbele S, et al. Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis. Lancet Infect Dis. 2017;17(9):990–1001.
Belda FJ, Aguilera L. Garcia de la Asuncion J, et al. supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA. 2005;294(16):2035–42.
Benenson AS. Control of communicable diseases manual. 16th ed. Washington: American Public Health Association; 1995.
Bigham MT, Amato R, Bondurrant P, et al. Ventilator-associated pneumonia in the pediatric intensive care unit: characterizing the problem and implementing a sustainable solution. J Pediatr. 2009;154(4):582–587.e2.
Boev C, Kiss E. Hospital-acquired infections: current trends and prevention. Crit Care Nurs Clin North Am. 2017;29:51–65.
Bratzler DW, Hunt DR. The surgical infection prevention and surgical care improvement projects: national initiatives to improve outcomes for patients having surgery. Clin Infect Dis. 2006;43(3):322–30.
Brilli RJ, Sparling KW, Lake MR, et al. The business case for preventing ventilator-associated pneumonia in pediatric intensive care unit patients. Jt Comm J Qual Patient Saf. 2008;34(11):629–38.
Brissaud O, Guichoux J, Harambat J, Tandonnet O, Zaoutis T. Invasive fungal disease in PICU: epidemiology and risk factors. Ann Intensive Care. 2012;2(1):6.
Casado RJ, de Mello MJ, de Aragao RC, de Albuquerque MF, Correia JB. Incidence and risk factors for health care-associated pneumonia in a pediatric intensive care unit. Crit Care Med. 2011;39(8):1968–73.
CDC. National and State Healthcare-Associated Infections progress report. 2016. Available at: http://www.cdc.gov/HAI/pdfs/progress-report/hai-progress-report.pdf.
Coetzee M. Are children really different from adults in critical care settings? S Afr J Crit Care. 2005;21:70–5.
Culver DH, Horan TC, Gaynes RP, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance System. Am J Med. 1991;91(3B):152S–7S.
Dasgupta S, Das S, Chawan NS, Hazra A. Nosocomial infections in the intensive care unit: incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of eastern India. Indian J Crit Care Med. 2015;19:14–20.
Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011;86(11):1113–23.
Frank DN, St Amand AL, Feldman RA, et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104(34):13780–5.
Gerding DN. The search for good antimicrobial stewardship. Jt Comm J Qual Improv. 2001;27:403–4.
Gould CV, Umscheid CV, Agarwal RK, et al. Guideline for prevention of catheter associated urinary tract infections. Infect Control Hosp Epidemiol. 2010;31:319–26.
Greif R, Akca O, Horn EP, et al. Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection. N Engl J Med. 2000;342(3):161–7.
Gupta A, Kapil A, Lodha R, Kabra SK, Sood S, Dhawan B, et al. Burden of healthcare-associated infections in a paediatric intensive care unit of a developing country: a single Centre experience using active surveillance. J Hosp Infect. 2011;78(4):323–6.
Gupta S, Boville BM, Blanton R, et al. A multicentered prospective analysis of diagnosis, risk factors, and outcomes associated with pediatric ventilator associated pneumonia. Pediatr Crit Care Med. 2015;16(3):e65–73.
Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial- resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for disease control and prevention, 2006-2007. Infect Control Hosp Epidemiol. 2008;29(11):996–1011.
Horan TC, Gaynes RP, Martone WJ, et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Am J Infect Control. 1992;20(5):271–4.
Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–32.
Jain V, Bhardwaj A. StatPearls [internet]. StatPearls publishing; Treasure Island (FL): Feb 22, 2019. Pneumonia pathology. /// Iosifidis E, Pitsava G, Roilides E. ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention. Future Microbiol. 2018;13:1431–46.
Jernigan JA. Is the burden of Staphylococcus aureus among patients with surgical-site infections growing? Infect Control Hosp Epidemiol. 2004;25(6):457–60.
Joram N, de Saint BL, Stamm D, Launay E, Gras-Le GC. Healthcare-associated infection prevention in pediatric intensive care units: a review. Eur J Clin Microbiol Infect Dis. 2012;31(10):2481–90.
Joseph J, Rodvold KA. The role of carbapenems in the treatment of severe nosocomial respiratory tract infections. Expert Opin Pharmacother. 2008;9(4):561–75.
Klevens RM, Edwards JR, Richards CL Jr, et al. Estimating health care- associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007;122(2):160–6.
Lake JG, Weiner LM, Milstone AM, Saiman L, Magill SS, See I. Pathogen distribution and antimicrobial resistance among pediatric healthcare-associated infections reported to the National Healthcare Safety Network 2011–2014. Infect Cont Hosp Epidemiol. 2017;39:1–11.
Lodha R, Natchu UC, Nanda M, Kabra SK. Nosocomial infections in pediatric intensive care units. Indian J Pediatr. 2001;68(11):1063–70.
Losifidis E, Pitsava G, Roilides E. Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention. Future Microbiol. 2018;13:1431–46.
Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Am J Infect Control. 1999;27(2):97–134.
McBeth CL, Montes RS, Powne A, North SE, Natale JE. Interprofessional approach to the sustained reduction in ventilator-associated-pneumonia in a pediatric intensive care unit. Crit Care Nurse. 2018 Dec;38(6):36–45.
Meyhoff CS, Wetterslev J, Jorgensen LN, et al. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial. JAMA. 2009;302(14):1543–50.
Morowitz MJ, Babrowski T, Carlisle EM, et al. The human microbiome and surgical disease. Ann Surg. 2011;253(6):1094–101.
NNIS. National Nosocomial Infections Surveillance (NNIS) report, data summary from October 1986–April 1996, issued may 1996: a report from the National Nosocomial infections surveillance (NNIS) system. Am J Infect Control. 1996;24(5):380–8.
Northway T, Langley JM, Skippen P. Health care–associated infection in the pediatric intensive care unit. Pediatr Crit Care. 2011;143:1349–63.
O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52(9):e162–93.
Olivas AD, Shogan BD, Valuckaite V, et al. Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak. PLoS One. 2012;7(8):e44326.
Pryor KO, Fahey TJ 3rd, Lien CA, et al. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA. 2004;291(1):79–87.
Quinn P. Chasing zero: a nurse-driven process for catheter-associated urinary tract infection reduction in a community hospital. Nurs Econ. 2015;33:320–5.
Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European study group. Infect Control Hosp Epidemiol. 2000;21:260–3.
Rhee C, Huang SS, Berríos-Torres SI, Kaganov R, Bruce C, Lankiewicz J, Platt R. Yokoe DS; Centers for Disease Control and Prevention. Surgical site infection surveillance following ambulatory surgery. Infect Control Hosp Epidemiol. 2015 Feb;36:225–8.
Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in pediatric intensive care units in the United States. Natl Nosocom Infect Surveill SystPediatr. 1999;103(4):e39.
Sax H, Allegranzi B, Uçkay I, Larson E, Boyce J, Pittet D. ‘My five moments for hand hygiene’: a user-centred design approach to understand, train, monitor and report hand hygiene. J Hosp Infect. 2007;67:9–21.
Seksik P, Rigottier-Gois L, Gramet G, et al. Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon. Gut. 2003;52(2):237–42.
Sievert DM, Ricks P, Edwards JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the centers for disease control and prevention, 2009-2010. Infect Control Hosp Epidemiol. 2013;34(1):1–14.
Srinivasan R, Asselin J, Gildengorin G, Wiener-Kronish J, Flori HR. A prospective study of ventilator-associated pneumonia in children. Pediatrics. 2009;123(4):1108–15.
Tanner J, Woodings D, Moncaster K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev. 2006;3:CD004122.
Urrea M, Pons M, Serra M, Latorre C, Palomeque A. Prospective incidence study of nosocomial infections in a pediatric intensive care unit. Pediatr Infect Dis J. 2003;22(6):490–4.
Vijay G, Mandal A, Shankar J, Kapil A, Lodha R, Kabra SK. Ventilator associated pneumonia in pediatric intensive care unit: incidence, risk factors and etiological agents. Indian J Pediatr. 2018;85:861–6.
WHO Guidelines on Hand Hygiene in Health Care. First global patient safety challenge clean care is safer care. Geneva: World Health Organisation; 2009.
World Health Organization. Best infection control practices for skin-piercing intradermal, subcutaneous and intramuscular needle injections. 2001, WHO/ BCT/ DCT/ 01.02.
Wright MO, Decker SG, Allen-Bridson K, Hebden JN, Leaptrot D. Healthcare-associated infections studies project: an American journal of infection control and National Healthcare Safety Network data quality collaboration: location mapping. Am J Infect Control. 2018;46:577–8.
Young PY, Khadaroo RG. Surgical site infections. Surg Clin North Am. 2014;94:1245–64.
Zeigler MJ, Pellegrini DC, Safdar N. Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis. Infection. 2015;43:29–36.
Zilberberg MD, Shorr AF. Ventilator-associated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcome. Clin Infect Dis. 2010;31:676–82.
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Anand, S., Bajpai, M., Goel, P. (2020). Pediatric Infections in the Intensive Care Unit (ICU). In: Soneja, M., Khanna, P. (eds) Infectious Diseases in the Intensive Care Unit. Springer, Singapore. https://doi.org/10.1007/978-981-15-4039-4_24
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