Abstract
Epidemiological studies on allergy/asthma and cancer suggest that there exists association between these two types of immunological diseases. Atopic allergy can promote protection from certain types of cancer such as colorectal and esophageal cancers, whereas it may also serve as a risk factor for cancers like lung cancer. There are key immune cells like Tregs and macrophages that play a crucial role in immunoregulation of both the diseases. Besides, PD-1, PD-L1/L2, CTLA4, IgE, Type 2 cytokines regulate allergic manifestations and malignant conditions in the human system. In this chapter, the association of atopic allergy with different types of cancer, and the key immune cells and important molecules associated with both the diseases have been highlighted. In the end, the future perspectives of the field of allergo-oncology and possible therapeutic approaches to modulate the immune systems have been described.
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Majumdar, S., Saha, S. (2020). Systems Immunology Approach in Understanding the Association of Allergy and Cancer. In: Singh, S. (eds) Systems and Synthetic Immunology . Springer, Singapore. https://doi.org/10.1007/978-981-15-3350-1_2
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