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Plant Polyphenols and Gut Bacteria: Role in Obesity-Induced Metabolic Endotoxaemia and Inflammation

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Abstract

Plant polyphenols (PPs) play an important role in human nutrition due to their antioxidant capacity and the ability to reduce reactive oxygen species (ROS). PPs have been shown to alleviate diseases like type-2 diabetes, obesity, and cardiovascular diseases. Obesity is a disorder that arises due to a sedentary lifestyle besides genetic factors. Its prevalence is rapidly increasing over the past three decades all over the world, including India. Many preclinical studies suggested that plant phenolics could alleviate diet-induced obesity. The usage of PPs is gaining importance, and it is the subject of intensive research due to the ability of gut microbes in metabolizing these compounds. Among PPs, phenolic acids account for one-third of the total intake and flavonoids for the remaining two-thirds of the total intake. In this chapter, the impact of plant-derived PPs is emphasized based on its role in the prevention of obesity and associated low-grade inflammation through their gut modulatory microbial effects is highlighted.

Graphical Abstract

The putative role of millet polyphenol-rich extract against high-fat diet-induced obesity and its related metabolic complication.

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Authors and Affiliations

  1. Healthy Gut Research Group, Food and Nutrition Biotechnology Division, National Agri-Food Biotechnology Institute, Mohali, Punjab, India

    Ruchika Maurya, Mahendra Bishnoi & Kanthi Kiran Kondepudi

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  1. Ruchika Maurya
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  2. Mahendra Bishnoi
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  3. Kanthi Kiran Kondepudi
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Correspondence to Kanthi Kiran Kondepudi .

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Editors and Affiliations

  1. Department of Agriculture Biotechnology, National Agri-Food Biotechnology, Mohali, Punjab, India, Division of Crop Science, Indian Council of Agricultural Research, New Delhi, India

    Tilak Raj Sharma

  2. Department of Agriculture Biotechnology, National Agri-Food Biotechnology, Mohali, Punjab, India

    Rupesh Deshmukh

  3. Department of Agriculture Biotechnology, National Agri-Food Biotechnology, Mohali, Punjab, India

    Humira Sonah

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Maurya, R., Bishnoi, M., Kondepudi, K.K. (2020). Plant Polyphenols and Gut Bacteria: Role in Obesity-Induced Metabolic Endotoxaemia and Inflammation. In: Sharma, T.R., Deshmukh, R., Sonah, H. (eds) Advances in Agri-Food Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-2874-3_10

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