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Construction and Biomedical Applications of Macrocycle-Based Supramolecular Topological Polymers

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Handbook of Macrocyclic Supramolecular Assembly

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Abstract

A number of macrocyclic host molecules with cavities such as crown ethers, cyclodextrins, calix[n]arenes, cucurbit[n]urils, and pillar[n]arenes have been exploited to encapsulate the guests for the construction of novel supramolecular systems and great potential applications in various fields such as biomedicine, photoelectricity, and catalysis. On the other aspect, great attentions have been attracted by supramolecular polymers (SPs), which is the intersection of supramolecular chemistry and polymer science. The properties and functions of SPs are strongly affected by their higher-level topological structures. Therefore, macrocycle-based supramolecular topological polymers (STPs) are superior in the complication and hierarchy of structures compared with linear SPs due to more diverse possible combinations between unique topological polymer structures and macrocycle-based supramolecular interactions. In this chapter, we aim to summarize the construction and biomedical applications of macrocycle-based STPs. Especially, we will discuss macrocycle-based STPs with diverse structures and responsive functional characteristics and latest applications in the biomedical applications. We want to clarify the distinct structure property features of macrocycle-based STPs and reveal their promising potential in biomedical applications. We hope this chapter could provide a reference or inspirations for chemists working on macrocycle-based STPs.

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Acknowledgments

We thank National Natural Science Foundation of China (21674086, 21374088) and Natural Science Basic Research Plan in Shaanxi Province of China (2018JZ2003) for financial support.

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Authors and Affiliations

  1. MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an, China

    Wenzhuo Chen, Chengfei Liu, Xin Song, Xuedong Xiao, Shuai Qiu & Wei Tian

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  1. Wenzhuo Chen
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  2. Chengfei Liu
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  3. Xin Song
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  4. Xuedong Xiao
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  5. Shuai Qiu
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  6. Wei Tian
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Correspondence to Wei Tian .

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Editors and Affiliations

  1. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yu Liu

  2. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yong Chen

  3. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Heng-Yi Zhang

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Chen, W., Liu, C., Song, X., Xiao, X., Qiu, S., Tian, W. (2020). Construction and Biomedical Applications of Macrocycle-Based Supramolecular Topological Polymers. In: Liu, Y., Chen, Y., Zhang, HY. (eds) Handbook of Macrocyclic Supramolecular Assembly . Springer, Singapore. https://doi.org/10.1007/978-981-15-2686-2_65

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