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Responsive Supramolecular Vesicles Based on Host-Guest Recognition for Biomedical Applications

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Handbook of Macrocyclic Supramolecular Assembly

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Abstract

Fabrication of responsive materials is an important research area, which is intimately associated with advanced applications such as smart delivery systems, stimulus-responsive actuators, and soft robots. To achieve responsive materials, the utilization of noncovalent forces to integrate organic building units is a favorable approach. Such supramolecular self-assembly is sensitive to specific stimuli such as light, pH, temperature, and redox agents. Among noncovalent forces, host-guest interaction occurring between macrocyclic hosts and guest molecules can combine two or more species into an amphiphile system that gives rise to diverse micro-/nanostructures after the self-assembly. Compared to normal amphiphiles, host-guest amphiphiles show high sensitivity to external stimuli, demonstrating advantages in the fabrication of smart materials. In this chapter, we discuss the preparation, characterization, and application of external stimulus-responsive vesicle systems self-assembled from integrated host-guest building blocks. By summarizing recent important developments, we introduce the preparation of vesicular structures according to the type of macrocylic hosts. Then, general principles for achieving stimulus responsiveness are discussed. Finally, we highlight some biomedical applications of responsive supramolecular vesicles prepared from host-guest amphiphiles. It is expected that this chapter would provide useful information to researchers who are interested in the areas of supramolecular chemistry, self-assembly, responsive materials, and supramolecular theranostics.

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Acknowledgments

This research is supported by the Singapore National Research Foundation Investigatorship (No. NRF-NRFI2018-03), the PhD Start-up Scientific Research Foundation of Jining Medical University (No. 2017JYQD03), and NSFC Cultivation Project of Jining Medical University (No. JYP2018KJ12).

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Authors and Affiliations

  1. Key Laboratory of Colloid and Interface Chemistry of Ministry of Education and School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

    Mingfang Ma & Pengyao Xing

  2. Laboratory of New Antitumor Drug Molecular Design and Synthesis of Jining Medical University, College of Basic Medicine, Jining Medical University, Jining, China

    Mingfang Ma

  3. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore

    Yanli Zhao

  4. School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore

    Yanli Zhao

Authors
  1. Mingfang Ma
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  2. Pengyao Xing
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  3. Yanli Zhao
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Corresponding authors

Correspondence to Pengyao Xing or Yanli Zhao .

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Editors and Affiliations

  1. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yu Liu

  2. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yong Chen

  3. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Heng-Yi Zhang

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Ma, M., Xing, P., Zhao, Y. (2020). Responsive Supramolecular Vesicles Based on Host-Guest Recognition for Biomedical Applications. In: Liu, Y., Chen, Y., Zhang, HY. (eds) Handbook of Macrocyclic Supramolecular Assembly . Springer, Singapore. https://doi.org/10.1007/978-981-15-2686-2_59

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