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Construction of Glyco-nanostructures Through the Self-Assembly of Saccharide-Containing Macrocyclic Amphiphiles

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Handbook of Macrocyclic Supramolecular Assembly

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Abstract

Glyco-nanostructures (GNSs) have aroused great interest during the past decades thanks to their wide applications including, nanomedicine, nanoreactor and nanosensors. Consequently, a lot of methods, such as self-assembly of glycopolymers, post-modification of organic/inorganic particles and glycodendrimers, and so forth have been developed for the production of GNSs. In this chapter, we mainly summarize the recent advances in the fabrication of GNSs with an emphasis on a new and unique strategy of self-assembly of macrocyclic amphiphiles. This interesting method not only can tailor the GNSs with well-defined and diverse structures through precisely locating hydrophilic and hydrophobic parts on the respective sides of macrocycles, but also endow the GNSs with good dynamic and reversible nature due to the involvement of host-guest interactions. Moreover, the mediation of noncovalent interactions of these GNSs may benefit us to further understand the biological process, such as cell-cell and cell-pathogen interactions, as well as immune response.

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Acknowledgments

We thank financial support of CPSF (No. 2017M621354 and 2018T110335) for generous financial support.

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Authors and Affiliations

  1. The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, China

    Guang Yang & Guosong Chen

Authors
  1. Guang Yang
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  2. Guosong Chen
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Corresponding author

Correspondence to Guosong Chen .

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Editors and Affiliations

  1. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yu Liu

  2. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yong Chen

  3. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Heng-Yi Zhang

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Yang, G., Chen, G. (2020). Construction of Glyco-nanostructures Through the Self-Assembly of Saccharide-Containing Macrocyclic Amphiphiles. In: Liu, Y., Chen, Y., Zhang, HY. (eds) Handbook of Macrocyclic Supramolecular Assembly . Springer, Singapore. https://doi.org/10.1007/978-981-15-2686-2_41

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