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Modulation of Chemical and Biological Properties of Biomedically Relevant Guest Molecules by Cucurbituril-Type Hosts

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Handbook of Macrocyclic Supramolecular Assembly

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Abstract

Cucurbituril-type (CB-type) molecules have played key roles in host-guest chemistry as well as supramolecular chemistry. Along with the development and synthetic expansion of CB-type molecules during the past two decades, their applications in a variety of research areas have been investigated. In particular, CB-type molecules have been found to modulate the chemical and biological properties of biomedically relevant molecules via host-guest complexations, including pKa shift, solubility/stability enhancement, therapeutic efficacy modulation, and toxicity reduction. This chapter summarizes these investigations and their implications in biomedical sciences.

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Acknowledgments

This work was supported by National Science Foundation of China (21871301), Macau Science and Technology Development Fund (FDCT 030/2017/A1 and FDCT 0121/2018/A3) and the Research Committee at the University of Macau (MYRG2016-00008-ICMS-QRCM, MYRG2016-00165-ICMS-QRCM and MYRG2017-00010-ICMS).

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  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China

    Hang Yin, Ziyi Wang & Ruibing Wang

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  1. Hang Yin
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  2. Ziyi Wang
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  3. Ruibing Wang
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Correspondence to Ruibing Wang .

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Editors and Affiliations

  1. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yu Liu

  2. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Yong Chen

  3. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

    Heng-Yi Zhang

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Yin, H., Wang, Z., Wang, R. (2020). Modulation of Chemical and Biological Properties of Biomedically Relevant Guest Molecules by Cucurbituril-Type Hosts. In: Liu, Y., Chen, Y., Zhang, HY. (eds) Handbook of Macrocyclic Supramolecular Assembly . Springer, Singapore. https://doi.org/10.1007/978-981-15-2686-2_28

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