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Quorum Quenching for Sustainable Environment: Biology, Mechanisms, and Applications

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Microbial Technology for Health and Environment

Part of the book series: Microorganisms for Sustainability ((MICRO,volume 22))

Abstract

Quorum sensing signaling is a hierarchal system in bacteria to communicate with each other and coordinate their activities. Prevention of the QS pathway by disrupting signals is called quorum quenching (QQ), which is essential not just in medicine and healthcare settings but also in membrane bioreactors, aquaculture, and agriculture. QQ could be achieved either by interfering with the QS signaling pathway (e.g., signal generator or receptor) or intercepting the QS molecules. Research on QQ led to the development of strategies that mitigate biofilm-based problems in medicine, agronomy, and water engineering. The QQ-strategy is being given importance in recent times as there is an immediate need to search for an alternative or a complementary approach to phytochemicals and antibiotics. This chapter starts with the historical aspects of QQ; furthermore, it highlights the global research in the area of QQ and the mechanism of quenching pathways. Afterward, applications of QQ-strategies in medicine, agriculture, aquaculture, and water engineering are discussed. Finally, challenges and prospects of QQ technology are delineated.

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Abbreviations

AHLs/HSL:

N-acyl homoserine lactones

AI-2:

Auto Inducer 2

AIPs:

Autoinducing peptides

AMR:

Anti-microbial resistance

CA:

Canada

FO-MBR:

Forward osmosis-MBR

GCL:

γ-Caprolactone

GMP:

Guanosine monophosphate

IDRC:

International Development Research Centre

MBBR:

Moving bed biofilm reactors

MBfR:

Membrane biofilm reactors

MBRs:

Membrane bioreactors

MIC:

Minimum inhibitory concentration

MRSA:

Methicillin-resistant Staphylococcus aureus

NIH:

National Institute of Health

Ntn:

N-terminal nucleophile

ORFs:

Open reading frames

PLLs:

Phosphotriesterase-like lactonases

PON:

Paraoxonase

QQ:

Quorum quenching

QQ-AnMBR:

QQ-anaerobic MBR

QQ-RO:

QQ-reverse osmosis

QS:

Quorum sensing

QSIs:

Quorum sensing inhibitors

SiNPs:

Silver nanoparticles

USA:

United States of America

WHO:

World Health Organization

WWT:

Wastewater treatment

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Acknowledgments

Dr. Naga Raju Maddela greatly acknowledges the Universidad Téchnica de Manabí, Portoviejo, Manabí, Ecuador, for the facilities and encouragement and his colleagues in the Instituto de Investigación and Facultad la Ciencias la Salud for their help in literature collection. The authors also thank Editor Dr. Pankaj Kumar Arora (Assistant Professor, Babasaheb Bhimrao Ambedkar University, Lucknow, India) for guidance and accepting our request to write this chapter.

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Authors and Affiliations

  1. Instituto de Investigación, Universidad Técnica de Manabí, Portoviejo, Ecuador

    Naga Raju Maddela, Luz Cecilia García Cruzatty & Daniel Alfredo Leal-Alvarado

  2. Faculdad la Ciencias la Salud, Universidad Técnica de Manabí, Portoviejo, Ecuador

    Naga Raju Maddela

  3. Faculdad de Agronomía, Universidad Técnica de Manabí, Portoviejo, Ecuador

    Luz Cecilia García Cruzatty, Daniel Alfredo Leal-Alvarado & Jessenia Castro Olaya

  4. School of Energy & Environmental Engineering, Hebei University of Technology, Tianjin, People’s Republic of China

    Sagnik Chakraborty

  5. Department of Chemical Engineering, Haldia Institute of Technology, Haldia, Purba Medinipur, West Bengal, India

    Anupam Mukherjee

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  1. Naga Raju Maddela
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  2. Luz Cecilia García Cruzatty
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  3. Daniel Alfredo Leal-Alvarado
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  4. Jessenia Castro Olaya
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  5. Sagnik Chakraborty
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  6. Anupam Mukherjee
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Correspondence to Naga Raju Maddela .

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Editors and Affiliations

  1. Department of Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

    Pankaj Kumar Arora

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Maddela, N.R., García Cruzatty, L.C., Leal-Alvarado, D.A., Olaya, J.C., Chakraborty, S., Mukherjee, A. (2020). Quorum Quenching for Sustainable Environment: Biology, Mechanisms, and Applications. In: Arora, P. (eds) Microbial Technology for Health and Environment. Microorganisms for Sustainability, vol 22. Springer, Singapore. https://doi.org/10.1007/978-981-15-2679-4_4

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