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Gut Microbiota and Liver Injury (I)—Acute Liver Injury

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Gut Microbiota and Pathogenesis of Organ Injury

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1238))

Abstract

Over the last few decades, intestinal microbial communities have been considered to play a vital role in host liver health. Acute liver injury (ALI) is the manifestation of sudden hepatic injury and arises from a variety of causes. The studies of dysbiosis in gut microbiota provide new insight into the pathogenesis of ALI. However, the relationship of gut microbiota and ALI is not well understood, and the contribution of gut microbiota to ALI has not been well characterized. In this chapter, we integrate several major pathogenic factors in ALI with the role of gut microbiota to stress the significance of gut microbiota in prevention and treatment of ALI.

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Authors and Affiliations

  1. Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, N.No 1838 Guangzhou Ave., Guangzhou, 510515, China

    Guangyan Wu & Peng Chen

  2. USC Research Center for Liver Disease, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, 90089, USA

    Sanda Win, Tin A. Than & Neil Kaplowitz

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  1. Guangyan Wu
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  2. Sanda Win
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  3. Tin A. Than
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  4. Peng Chen
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  5. Neil Kaplowitz
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Correspondence to Neil Kaplowitz .

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  1. Department of Pathophysiology, Southern Medical University, Guangzhou, Guangdong, China

    Peng Chen

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Wu, G., Win, S., Than, T.A., Chen, P., Kaplowitz, N. (2020). Gut Microbiota and Liver Injury (I)—Acute Liver Injury. In: Chen, P. (eds) Gut Microbiota and Pathogenesis of Organ Injury. Advances in Experimental Medicine and Biology, vol 1238. Springer, Singapore. https://doi.org/10.1007/978-981-15-2385-4_3

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