Skip to main content

Exercise and Depressive Disorder

  • Chapter
  • First Online:
Physical Exercise for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1228))

Abstract

Depression is a psychiatric disorder characterized by low mood, loss of interest/enjoyment, and reduced energy and one of the five leading causes of disability and a major contributor to all-cause mortality worldwide. People with depression have, between others, a reduced life expectancy, worse quality of life and cardiorespiratory fitness, and increased risk of type 2 diabetes, compared to the general population. Furthermore, the economic burden of mental disorders including depression is evident, and it is expected to increase to more than double by 2030. Therefore, reducing the growing burden of mental disorders such as depression should be a health priority. Improved prevention and treatment are two key factors that may reduce the burden of depression. Pharmacological- and psychotherapy-based interventions have been traditionally considered for treating depression disorders; however, there is an increasing amount of scientific evidence confirming that physical activity and physical exercise should be highly considered in prevention and treatment of depressive disorders. In this chapter, we aim to summarize and discuss the research progress of physical activity and exercise in prevention and treatment of depressive disorder. Specifically, we summarized and discussed the research progress of the prognostic use of physical activity for incident depression, the importance of sedentary behavior and other outcomes typically improved by physical activity/exercise such as cardiorespiratory fitness for future depression, the research progress of the evidence of the benefits of exercise in people with depression disorders, the resistance training effects in adults and older adults with depression, and the recommendations for the prescription of exercise for people with depression.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines, vol 1. World Health Organization, Geneva

    Google Scholar 

  2. Mental Illness. https://www.nimh.nih.gov/health/statistics/mental-illness.shtml

    Google Scholar 

  3. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1789–1858

    Article  Google Scholar 

  4. Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 72(4):334–341

    Article  PubMed  PubMed Central  Google Scholar 

  5. Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, Thapa-Chhetri N, Fornaro M, Gallicchio D, Collantoni E, Pigato G, Favaro A, Monaco F, Kohler C, Vancampfort D, Ward PB, Gaughran F, Carvalho AF, Stubbs B (2017) Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry 16(2):163–180

    Article  PubMed  PubMed Central  Google Scholar 

  6. Levola J, Pitkanen T, Kampman O, Aalto M (2018) The association of alcohol use and quality of life in depressed and non-depressed individuals: a cross-sectional general population study. Qual Life Res 27(5):1217–1226

    Article  PubMed  Google Scholar 

  7. Vancampfort D, Rosenbaum S, Schuch F, Ward PB, Richards J, Mugisha J, Probst M, Stubbs B (2017) Cardiorespiratory fitness in severe mental illness: a systematic review and meta-analysis. Sports Med 47(2):343–352

    Article  PubMed  Google Scholar 

  8. Taylor HL, Buskirk E, Henschel A (1955) Maximal oxygen intake as an objective measure of cardio-respiratory performance. J Appl Physiol 8(1):73–80

    Article  CAS  PubMed  Google Scholar 

  9. Vancampfort D, Mitchell AJ, De Hert M, Sienaert P, Probst M, Buys R, Stubbs B (2015) Type 2 diabetes in patients with major depressive disorder: a meta-analysis of prevalence estimates and predictors. Depress Anxiety 32(10):763–773

    Article  PubMed  Google Scholar 

  10. Vancampfort D, Correll CU, Wampers M, Sienaert P, Mitchell AJ, De Herdt A, Probst M, Scheewe TW, De Hert M (2013) Metabolic syndrome and metabolic abnormalities in patients with major depressive disorder: a meta-analysis of prevalences and moderating variables. Psychol Med 44:1–12

    Google Scholar 

  11. Persons JE, Fiedorowicz JG (2016) Depression and serum low-density lipoprotein: a systematic review and meta-analysis. J Affect Disord 206:55–67

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Meng L, Chen D, Yang Y, Zheng Y, Hui R (2012) Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies. J Hypertens 30(5):842–851

    Article  CAS  PubMed  Google Scholar 

  13. Boden JM, Fergusson DM (2011) Alcohol and depression. Addiction 106(5):906–914

    Article  PubMed  Google Scholar 

  14. Chaiton MO, Cohen JE, O'Loughlin J, Rehm J (2009) A systematic review of longitudinal studies on the association between depression and smoking in adolescents. BMC Public Health 9:356

    Article  PubMed  PubMed Central  Google Scholar 

  15. Trautmann S, Rehm J, Wittchen HU (2016) The economic costs of mental disorders: do our societies react appropriately to the burden of mental disorders? EMBO Rep 17(9):1245–1249

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Wykes T, Haro JM, Belli SR, Obradors-Tarrago C, Arango C, Ayuso-Mateos JL, Bitter I, Brunn M, Chevreul K, Demotes-Mainard J, Elfeddali I, Evans-Lacko S, Fiorillo A, Forsman AK, Hazo JB, Kuepper R, Knappe S, Leboyer M, Lewis SW, Linszen D, Luciano M, Maj M, McDaid D, Miret M, Papp S, Park AL, Schumann G, Thornicroft G, van der Feltz-Cornelis C, van Os J, Wahlbeck K, Walker-Tilley T, Wittchen HU (2015) Mental health research priorities for Europe. Lancet Psychiatry 2(11):1036–1042

    Article  PubMed  Google Scholar 

  17. Bueno-Antequera J, Oviedo-Caro MA, Munguia-Izquierdo D (2017) Relationship between objectively measured sedentary behavior and health outcomes in schizophrenia patients: the PsychiActive project. Schizophr Res 197:6

    Google Scholar 

  18. Bueno-Antequera J, Oviedo-Caro MA, Munguia-Izquierdo D (2017) Sedentary behaviour patterns in outpatients with severe mental illness: a cross-sectional study using objective and self-reported methods. The PsychiActive project. Psychiatry Res 255:146–152

    Article  PubMed  Google Scholar 

  19. Bueno-Antequera J, Oviedo-Caro MA, Munguia-Izquierdo D (2018) Sedentary behaviour, physical activity, cardiorespiratory fitness and cardiometabolic risk in psychosis: the PsychiActive project. Schizophr Res 195:142–148

    Article  PubMed  Google Scholar 

  20. Bueno-Antequera J, Oviedo-Caro MA, Munguia-Izquierdo D (2018) Ideal cardiovascular health and its association with sedentary behaviour and fitness in psychiatric patients. The PsychiActive project. Nutr Metab Cardiovasc Dis 28(9):900–908

    Article  CAS  PubMed  Google Scholar 

  21. Gorczynski P, Bratland-Sanda S, Lederman O, Bueno-Antequera J, Munguía-Izquierdo D (2018) Research to practice: case studies. In: Exercise-based interventions for mental illness. Elsevier, London, pp 319–335

    Chapter  Google Scholar 

  22. Caspersen CJ, Powell KE, Christenson GM (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 100(2):126–131

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Sedentary Behaviour Research N (2012) Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”. Appl Physiol Nutr Metab 37(3):540–542

    Article  Google Scholar 

  24. Vancampfort D, Firth J, Schuch FB, Rosenbaum S, Mugisha J, Hallgren M, Probst M, Ward PB, Gaughran F, De Hert M, Carvalho AF, Stubbs B (2017) Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry 16(3):308–315

    Article  PubMed  PubMed Central  Google Scholar 

  25. Teychenne M, Ball K, Salmon J (2008) Physical activity and likelihood of depression in adults: a review. Prev Med 46(5):397–411

    Article  PubMed  Google Scholar 

  26. Mammen G, Faulkner G (2013) Physical activity and the prevention of depression: a systematic review of prospective studies. Am J Prev Med 45(5):649–657

    Article  PubMed  Google Scholar 

  27. Schuch FB, Vancampfort D, Firth J, Rosenbaum S, Ward PB, Silva ES, Hallgren M, Ponce De Leon A, Dunn AL, Deslandes AC, Fleck MP, Carvalho AF, Stubbs B (2018) Physical activity and incident depression: a meta-analysis of prospective Cohort studies. Am J Psychiatr 175(7):631–648

    Article  PubMed  Google Scholar 

  28. Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J (2015) Unhealthy lifestyle may increase later depression via inflammation in older women but not men. J Psychiatr Res 63:65–74

    Article  PubMed  Google Scholar 

  29. Zhang XC, Woud ML, Becker ES, Margraf J (2018) Do health-related factors predict major depression? A longitudinal epidemiologic study. Clin Psychol Psychother 25(3):378–387

    Article  PubMed  Google Scholar 

  30. Kanamori S, Takamiya T, Inoue S, Kai Y, Tsuji T, Kondo K (2018) Frequency and pattern of exercise and depression after two years in older Japanese adults: the JAGES longitudinal study. Sci Rep 8(1):11224

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  31. Trumpf J, Vriends N, Meyer AH, Becker ES, Neumer SP, Margraf J (2010) The Dresden predictor study of anxiety and depression: objectives, design, and methods. Soc Psychiatry Psychiatr Epidemiol 45(9):853–864

    Article  PubMed  Google Scholar 

  32. Kondo K (2016) Progress in aging epidemiology in Japan: the JAGES project. Am J Epidemiol 26(7):331–336

    Article  Google Scholar 

  33. Harvey SB, Overland S, Hatch SL, Wessely S, Mykletun A, Hotopf M (2018) Exercise and the prevention of depression: results of the HUNT Cohort study. Am J Psychiatr 175(1):28–36

    Article  PubMed  Google Scholar 

  34. Krokstad S, Langhammer A, Hveem K, Holmen TL, Midthjell K, Stene TR, Bratberg G, Heggland J, Holmen J (2013) Cohort profile: the HUNT study, Norway. Int J Epidemiol 42(4):968–977

    Article  CAS  PubMed  Google Scholar 

  35. Kurtze N, Rangul V, Hustvedt BE, Flanders WD (2008) Reliability and validity of self-reported physical activity in the Nord-Trondelag Health Study: HUNT 1. Scan J Public Health 36(1):52–61

    Article  Google Scholar 

  36. Kuwahara K, Honda T, Nakagawa T, Yamamoto S, Hayashi T, Mizoue T (2018) Intensity of leisure-time exercise and risk of depressive symptoms among Japanese workers: a Cohort study. Am J Epidemiol 28(2):94–98

    Article  Google Scholar 

  37. Kuwahara K, Honda T, Nakagawa T, Yamamoto S, Akter S, Hayashi T, Mizoue T (2016) Leisure-time exercise, physical activity during work and commuting, and risk of metabolic syndrome. Endocrine 53(3):710–721

    Article  CAS  PubMed  Google Scholar 

  38. Hu H, Kurotani K, Sasaki N, Murakami T, Shimizu C, Shimizu M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Nagahama S, Uehara A, Yamamoto M, Tomita K, Imai T, Nishihara A, Kochi T, Eguchi M, Miyamoto T, Hori A, Kuwahara K, Akter S, Kashino I, Kabe I, Liu W, Mizoue T, Kunugita N, Dohi S (2016) Optimal waist circumference cut-off points and ability of different metabolic syndrome criteria for predicting diabetes in Japanese men and women: Japan Epidemiology Collaboration on Occupational Health Study. BMC Public Health 16:220

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. McDowell CP, Dishman RK, Hallgren M, MacDonncha C, Herring MP (2018) Associations of physical activity and depression: results from the Irish Longitudinal study on ageing. Exp Gerontol 112:68–75

    Article  CAS  PubMed  Google Scholar 

  40. Hallgren M, Nguyen TT, Lundin A, Vancampfort D, Stubbs B, Schuch F, Bellocco R, Lagerros YT (2019) Prospective associations between physical activity and clinician diagnosed major depressive disorder in adults: a 13-year cohort study. Prev Med 118:38–43

    Article  PubMed  Google Scholar 

  41. Whelan BJ, Savva GM (2013) Design and methodology of the Irish longitudinal study on ageing. J Am Geriatr Soc 61(Suppl 2):S265–S268

    Article  PubMed  Google Scholar 

  42. Bellocco R, Jia C, Ye W, Lagerros YT (2010) Effects of physical activity, body mass index, waist-to-hip ratio and waist circumference on total mortality risk in the Swedish National March Cohort. Eur J Epidemiol 25(11):777–788

    Article  PubMed  Google Scholar 

  43. Lagerros YT, Bellocco R, Adami HO, Nyren O (2009) Measures of physical activity and their correlates: the Swedish National March Cohort. Eur J Epidemiol 24(4):161–169

    Article  PubMed  Google Scholar 

  44. Lagerros YT, Mucci LA, Bellocco R, Nyren O, Balter O, Balter KA (2006) Validity and reliability of self-reported total energy expenditure using a novel instrument. Eur J Epidemiol 21(3):227–236

    Article  PubMed  Google Scholar 

  45. Teychenne M, Ball K, Salmon J (2010) Sedentary behavior and depression among adults: a review. Int J Behav Med 17(4):246–254

    Article  PubMed  Google Scholar 

  46. Zhai L, Zhang Y, Zhang D (2015) Sedentary behaviour and the risk of depression: a meta-analysis. Br J Sports Med 49(11):705–709

    Article  PubMed  Google Scholar 

  47. Liu M, Wu L, Yao S (2016) Dose-response association of screen time-based sedentary behaviour in children and adolescents and depression: a meta-analysis of observational studies. Br J Sports Med 50(20):1252–1258

    Article  PubMed  Google Scholar 

  48. Hallgren M, Herring MP, Owen N, Dunstan D, Ekblom O, Helgadottir B, Nakitanda OA, Forsell Y (2016) Exercise, physical activity, and sedentary behavior in the treatment of depression: broadening the scientific perspectives and clinical opportunities. Front Psychiatry 7:36

    Article  PubMed  PubMed Central  Google Scholar 

  49. Vancampfort D, Stubbs B, Firth J, Van Damme T, Koyanagi A (2018) Sedentary behavior and depressive symptoms among 67,077 adolescents aged 12-15 years from 30 low- and middle-income countries. Int J Behav Nutr Phys Act 15(1):73

    Article  PubMed  PubMed Central  Google Scholar 

  50. Stubbs B, Vancampfort D, Firth J, Schuch FB, Hallgren M, Smith L, Gardner B, Kahl KG, Veronese N, Solmi M, Carvalho AF, Koyanagi A (2018) Relationship between sedentary behavior and depression: a mediation analysis of influential factors across the lifespan among 42,469 people in low- and middle-income countries. J Affect Disord 229:231–238

    Article  PubMed  Google Scholar 

  51. Kowal P, Chatterji S, Naidoo N, Biritwum R, Fan W, Lopez Ridaura R, Maximova T, Arokiasamy P, Phaswana-Mafuya N, Williams S, Snodgrass JJ, Minicuci N, D’Este C, Peltzer K, Boerma JT (2012) Data resource profile: the World Health Organization Study on global AGEing and adult health (SAGE). Int J Epidemiol 41(6):1639–1649

    Article  PubMed  PubMed Central  Google Scholar 

  52. Vallance JK, Winkler EA, Gardiner PA, Healy GN, Lynch BM, Owen N (2011) Associations of objectively-assessed physical activity and sedentary time with depression: NHANES (2005-2006). Prev Med 53(4–5):284–288

    Article  PubMed  Google Scholar 

  53. Zahl T, Steinsbekk S, Wichstrom L (2017) Physical activity, sedentary behavior, and symptoms of major depression in middle childhood. Pediatrics 139(2). https://doi.org/10.1542/peds.2016-1711

  54. Ku PW, Steptoe A, Liao Y, Sun WJ, Chen LJ (2018) Prospective relationship between objectively measured light physical activity and depressive symptoms in later life. Int J Geriatr Psychiatry 33(1):58–65

    Article  PubMed  Google Scholar 

  55. Andrade-Gomez E, Martinez-Gomez D, Rodriguez-Artalejo F, Garcia-Esquinas E (2018) Sedentary behaviors, physical activity, and changes in depression and psychological distress symptoms in older adults. Depress Anxiety 35(9):884–897

    Article  PubMed  Google Scholar 

  56. Hallgren M, Owen N, Stubbs B, Zeebari Z, Vancampfort D, Schuch F, Bellocco R, Dunstan D, Trolle Lagerros Y (2018) Passive and mentally-active sedentary behaviors and incident major depressive disorder: a 13-year cohort study. J Affect Disord 241:579–585

    Article  PubMed  Google Scholar 

  57. Hamer M, Stamatakis E (2014) Prospective study of sedentary behavior, risk of depression, and cognitive impairment. Med Sci Sports Exerc 46(4):718–723

    Article  PubMed  PubMed Central  Google Scholar 

  58. Lucas M, Mekary R, Pan A, Mirzaei F, O’Reilly EJ, Willett WC, Koenen K, Okereke OI, Ascherio A (2011) Relation between clinical depression risk and physical activity and time spent watching television in older women: a 10-year prospective follow-up study. Am J Epidemiol 174(9):1017–1027

    Article  PubMed  PubMed Central  Google Scholar 

  59. Joo J, Williamson SA, Vazquez AI, Fernandez JR, Bray MS (2019) The influence of 15-week exercise training on dietary patterns among young adults. Int J Obesity (Lond). https://doi.org/10.1038/s41366-018-0299-3

  60. Schuch FB, Vancampfort D, Sui X, Rosenbaum S, Firth J, Richards J, Ward PB, Stubbs B (2016) Are lower levels of cardiorespiratory fitness associated with incident depression? A systematic review of prospective cohort studies. Prev Med 93:159–165

    Article  PubMed  Google Scholar 

  61. Gubata ME, Urban N, Cowan DN, Niebuhr DW (2013) A prospective study of physical fitness, obesity, and the subsequent risk of mental disorders among healthy young adults in army training. J Psychosom Res 75(1):43–48

    Article  PubMed  Google Scholar 

  62. Aberg MA, Waern M, Nyberg J, Pedersen NL, Bergh Y, Aberg ND, Nilsson M, Kuhn HG, Toren K (2012) Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study. Br J Psychiatry 201(5):352–359

    Article  PubMed  Google Scholar 

  63. Sui X, Laditka JN, Church TS, Hardin JW, Chase N, Davis K, Blair SN (2009) Prospective study of cardiorespiratory fitness and depressive symptoms in women and men. J Psychiatr Res 43(5):546–552

    Article  PubMed  Google Scholar 

  64. Dishman RK, Sui X, Church TS, Kline CE, Youngstedt SD, Blair SN (2015) Decline in cardiorespiratory fitness and odds of incident sleep complaints. Med Sci Sports Exerc 47(5):960–966

    Article  PubMed  PubMed Central  Google Scholar 

  65. Willis BL, Leonard D, Barlow CE, Martin SB, DeFina LF, Trivedi MH (2018) Association of midlife cardiorespiratory fitness with incident depression and cardiovascular death after depression in later life. JAMA Psychiatry 75(9):911–917

    Article  PubMed  PubMed Central  Google Scholar 

  66. Henriksson P, Henriksson H, Tynelius P, Berglind D, Lof M, Lee IM, Shiroma EJ, Ortega FB (2019) Fitness and body mass index during adolescence and disability later in life: a Cohort study. Ann Intern Med 170:230–239

    Article  PubMed  PubMed Central  Google Scholar 

  67. Firth J, Marx W, Dash S, Carney R, Teasdale SB, Solmi M, Stubbs B, Schuch FB, Carvalho AF, Jacka F, Sarris J (2019) The effects of dietary improvement on symptoms of depression and anxiety: a meta-analysis of randomized controlled trials. Psychosom Med 81:265–280

    Article  PubMed  PubMed Central  Google Scholar 

  68. Stubbs B, Vancampfort D, Hallgren M, Firth J, Veronese N, Solmi M, Brand S, Cordes J, Malchow B, Gerber M, Schmitt A, Correll CU, De Hert M, Gaughran F, Schneider F, Kinnafick F, Falkai P, Moller HJ, Kahl KG (2018) EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH). Eur Psychiatry J Assoc Eur Psychiatrists 54:124–144

    Article  Google Scholar 

  69. Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M (2009) AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol 62(10):1013–1020

    Article  PubMed  Google Scholar 

  70. Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, Porter AC, Tugwell P, Moher D, Bouter LM (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10

    Article  PubMed  PubMed Central  Google Scholar 

  71. Heun R, Gaebel W (2015) The relevance of EPA guidance papers in the framework of the European Psychiatric Association. Eur Psychiatry J Assoc Eur Psychiatrists 30(3):357–359

    Article  CAS  Google Scholar 

  72. Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, McMurdo M, Mead GE (2013) Exercise for depression. Cochrane Database Syst Rev 9. https://doi.org/10.1002/14651858.CD004366.pub6

  73. Ekkekakis P (2015) Honey, I shrunk the pooled SMD! Guide to critical appraisal of systematic reviews and meta-analyses using the Cochrane review on exercise for depression as example. Mental Health Phys Act 8:21–36

    Article  Google Scholar 

  74. Schuch FB, Vancampfort D, Richards J, Rosenbaum S, Ward PB, Stubbs B (2016) Exercise as a treatment for depression: a meta-analysis adjusting for publication bias. J Psychiatr Res 77:42–51

    Article  PubMed  Google Scholar 

  75. Schuch FB, Morres ID, Ekkekakis P, Rosenbaum S, Stubbs B (2017) A critical review of exercise as a treatment for clinically depressed adults: time to get pragmatic. Acta Neuropsychiatrica 29(2):65–71

    Article  PubMed  Google Scholar 

  76. Stubbs B, Vancampfort D, Rosenbaum S, Ward PB, Richards J, Ussher M, Schuch FB (2016) Challenges establishing the efficacy of exercise as an antidepressant treatment: a systematic review and meta-analysis of control group responses in exercise randomised controlled trials. Sports Med 46(5):699–713

    Article  PubMed  Google Scholar 

  77. Ruiz-Ruiz J, Mesa JL, Gutierrez A, Castillo MJ (2002) Hand size influences optimal grip span in women but not in men. J Hand Surg 27(5):897–901

    Article  Google Scholar 

  78. Schuch FB, Vancampfort D, Rosenbaum S, Richards J, Ward PB, Stubbs B (2016) Exercise improves physical and psychological quality of life in people with depression: a meta-analysis including the evaluation of control group response. Psychiatry Res 241:47–54

    Article  PubMed  Google Scholar 

  79. Kvam S, Kleppe CL, Nordhus IH, Hovland A (2016) Exercise as a treatment for depression: a meta-analysis. J Affect Disord 202:67–86

    Article  PubMed  Google Scholar 

  80. Stubbs B, Rosenbaum S, Vancampfort D, Ward PB, Schuch FB (2016) Exercise improves cardiorespiratory fitness in people with depression: a meta-analysis of randomized control trials. J Affect Disord 190:249–253

    Article  PubMed  Google Scholar 

  81. Harber MP, Kaminsky LA, Arena R, Blair SN, Franklin BA, Myers J, Ross R (2017) Impact of cardiorespiratory fitness on all-cause and disease-specific mortality: advances since 2009. Prog Cardiovasc Dis 60(1):11–20

    Article  PubMed  Google Scholar 

  82. Rahman MS, Helgadottir B, Hallgren M, Forsell Y, Stubbs B, Vancampfort D, Ekblom O (2018) Cardiorespiratory fitness and response to exercise treatment in depression. BJPsych Open 4(5):346–351

    Article  PubMed  PubMed Central  Google Scholar 

  83. Ross R, Blair SN, Arena R, Church TS, Despres JP, Franklin BA, Haskell WL, Kaminsky LA, Levine BD, Lavie CJ, Myers J, Niebauer J, Sallis R, Sawada SS, Sui X, Wisloff U (2016) Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation 134(24):653–699

    Article  Google Scholar 

  84. Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M (2017) A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Med 15(1):23

    Article  PubMed  PubMed Central  Google Scholar 

  85. Jacka FN, O'Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M (2018) Correction to: a randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES'’ trial). BMC Med 16(1):236

    Article  PubMed  PubMed Central  Google Scholar 

  86. Schuch FB, Vancampfort D, Rosenbaum S, Richards J, Ward PB, Veronese N, Solmi M, Cadore EL, Stubbs B (2016) Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias. Braz J Psychiatry 38(3):247–254

    Article  PubMed  PubMed Central  Google Scholar 

  87. Brondino N, Rocchetti M, Fusar-Poli L, Codrons E, Correale L, Vandoni M, Barbui C, Politi P (2017) A systematic review of cognitive effects of exercise in depression. Acta Psychiatr Scand 135(4):285–295

    Article  CAS  PubMed  Google Scholar 

  88. Silveira H, Moraes H, Oliveira N, Coutinho ES, Laks J, Deslandes A (2013) Physical exercise and clinically depressed patients: a systematic review and meta-analysis. Neuropsychobiology 67(2):61–68

    Article  PubMed  Google Scholar 

  89. de Souza Moura AM, Lamego MK, Paes F, Ferreira Rocha NB, Simoes-Silva V, Rocha SA, de Sa Filho AS, Rimes R, Manochio J, Budde H, Wegner M, Mura G, Arias-Carrion O, Yuan TF, Nardi AE, Machado S (2015) Comparison among aerobic exercise and other types of interventions to treat depression: asystematic review. CNS Neurol Disord Drug Targets 14(9):1171–1183

    Article  PubMed  CAS  Google Scholar 

  90. Pilu A, Sorba M, Hardoy MC, Floris AL, Mannu F, Seruis ML, Velluti C, Carpiniello B, Salvi M, Carta MG (2007) Efficacy of physical activity in the adjunctive treatment of major depressive disorders: preliminary results. Clin Pract Epidemiol Ment Health 3:8

    Article  PubMed  PubMed Central  Google Scholar 

  91. Krogh J, Saltin B, Gluud C, Nordentoft M (2009) The DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of strength versus aerobic versus relaxation training for patients with mild to moderate depression. J Clin Psychiatry 70(6):790–800

    Article  PubMed  Google Scholar 

  92. Singh NA, Clements KM, Fiatarone MA (1997) A randomized controlled trial of progressive resistance training in depressed elders. J Gerontol A Biol Sci Med Sci 52(1):M27–M35

    Article  CAS  PubMed  Google Scholar 

  93. Singh NA, Stavrinos TM, Scarbek Y, Galambos G, Liber C, Fiatarone Singh MA (2005) A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci 60(6):768–776

    Article  PubMed  Google Scholar 

  94. Sims J, Galea M, Taylor N, Dodd K, Jespersen S, Joubert L, Joubert J (2009) Regenerate: assessing the feasibility of a strength-training program to enhance the physical and mental health of chronic post stroke patients with depression. Int J Geriatr Psychiatry 24(1):76–83

    Article  CAS  PubMed  Google Scholar 

  95. Gordon BR, McDowell CP, Hallgren M, Meyer JD, Lyons M, Herring MP (2018) Association of efficacy of resistance exercise training with depressive symptoms: meta-analysis and meta-regression analysis of randomized clinical trials. JAMA Psychiatry 75(6):566–576

    Article  PubMed  Google Scholar 

  96. Rethorst CD, Trivedi MH (2013) Evidence-based recommendations for the prescription of exercise for major depressive disorder. J Psychiatr Pract 19(3):204–212

    Article  PubMed  Google Scholar 

  97. Stanton R, Reaburn P, Rosenbaum S (2013) Comment on the prescription of exercise for major depressive disorder: reply to Drs. Rethorst and Trivedi. J Psychiatr Pract 19(4):271–272

    Article  PubMed  Google Scholar 

  98. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43(7):1334–1359

    Article  PubMed  Google Scholar 

  99. Stubbs B, Vancampfort D, Rosenbaum S, Ward PB, Richards J, Soundy A, Veronese N, Solmi M, Schuch FB (2016) Dropout from exercise randomized controlled trials among people with depression: a meta-analysis and meta regression. J Affect Disord 190:457–466

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The work was funded by Research Group CTS-948, Universidad Pablo de Olavide, Andalusian Government; Universidad Pablo de Olavide, Spain “A2. Ayudas Puente para la Concurrencia al Plan Estatal de I+D”; European University of Madrid, Cátedra Real Madrid, Spain (funding project number P2017/RM08); Biomedical Research Networking Centre on Frailty and Healthy Aging (CIBERFES); and FEDER funds from the European Union (CB16/10/00477). JBA was supported by the Spanish Ministry of Education (grant number FPU13/05130) and by the Departamento de Innovación, Investigación y Universidad del Gobierno de Aragón y el Fondo Europeo de Desarrollo Regional – Programa Operativo FEDER Aragón 2014–2020 “Construyendo Europa desde Aragón” (reference number PUI/2018-337). The funders had no role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Diego Munguía-Izquierdo .

Editor information

Editors and Affiliations

Ethics declarations

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bueno-Antequera, J., Munguía-Izquierdo, D. (2020). Exercise and Depressive Disorder. In: Xiao, J. (eds) Physical Exercise for Human Health. Advances in Experimental Medicine and Biology, vol 1228. Springer, Singapore. https://doi.org/10.1007/978-981-15-1792-1_18

Download citation

Publish with us

Policies and ethics