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FDG-PET/CT in Patients with Inflammation or Fever of Unknown Origin (IUO and FUO)

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PET/CT for Inflammatory Diseases

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Abstract

Fever of unknown origin (FUO) is a syndrome of fever without obvious cause, and it is regarded as a difficult diagnostic challenge. Inflammation of unknown origin (IUO) is similar to FUO, except that it is not associated with elevated body temperature. FDG-PET/CT may cover the diagnosis of a wide spectrum of diseases causing FUO/IUO, namely tumors and inflammation, under the conditions that the disease is active (consuming a lot of glucose), and the lesion is focal and of a size that is sufficiently larger than the limit of detectability. Promising results of FDGPET/CT for the diagnosis of FUO/IUO have been reported from many institutions. FDGPET/CT is very helpful for recognizing and excluding diseases, directing further diagnostic decisions, and avoiding unnecessary invasive examinations. If confirmed by further studies, FDG-PET/CT may become established as an initial, noninvasive diagnostic tool in the evaluation of FUO/IUO.

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Author information

Authors and Affiliations

  1. Department of Radiology, Southern TOHOKU General Hospital, Koriyama, Fukushima, Japan

    Kazuo Kubota

  2. Department of Emergency and General Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    Motoki Takeuchi

  3. Department of General Internal Medicine, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan

    Motoki Takeuchi

  4. Department of Nuclear Medicine, Peking University People’s Hospital, Beijing, China

    Qian Wang

  5. Kyoto University Hospital, Kyoto, Japan

    Yuji Nakamoto

Authors
  1. Kazuo Kubota
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  2. Motoki Takeuchi
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  3. Qian Wang
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  4. Yuji Nakamoto
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Corresponding author

Correspondence to Kazuo Kubota .

Editor information

Editors and Affiliations

  1. Department of Radiology, Fujita Health University, Toyoake, Aichi, Japan

    Hiroshi Toyama

  2. Department of Nuclear Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China

    Yaming Li

  3. Joint Research Division for the Quantum Cancer Therapy, Research Center for Nuclear Physics, Professor Emeritus, Osaka University, Suita, Osaka, Japan

    Jun Hatazawa

  4. Shanghai University of Medicine & Health Sciences, Shanghai, China

    Guang Huang

  5. Department of Radiology, Southern TOHOKU General Hospital, Koriyama, Fukushima, Japan

    Kazuo Kubota

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Kubota, K., Takeuchi, M., Wang, Q., Nakamoto, Y. (2020). FDG-PET/CT in Patients with Inflammation or Fever of Unknown Origin (IUO and FUO). In: Toyama, H., Li, Y., Hatazawa, J., Huang, G., Kubota, K. (eds) PET/CT for Inflammatory Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-0810-3_2

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  • DOI: https://doi.org/10.1007/978-981-15-0810-3_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-0809-7

  • Online ISBN: 978-981-15-0810-3

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