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Autophagy Regulation of Mammalian Immune Cells

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Autophagy Regulation of Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Autophagy is a fully competent cellular machinery able to carry out the clearance of macromolecules via fusion with the lysosome. Many studies conducted in recent years have revealed that autophagy not only plays a critical role in maintaining cell homeostasis, but can also promote bacterial elimination. Additionally, autophagy exists in most eukaryotic cells including immune cells, such as lymphocytes, neutrophils, eosinophils, mast cells, and natural killer cells. Presently, there are numerous studies focusing on the roles of autophagy in regulating immune response. Autophagy regulates the innate and adaptive immunity by modulating cell differentiation, survival, phagocytosis, antigen presentation, degranulation, and cytokine production. In this chapter, we will summarize how autophagy participates explicitly in the survival and function of the mammalian adaptive and innate immune cells.

W. Z. He and W. J. Xiong—Contributed equally to this work.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

    Wenzhuo He, Wenjing Xiong & Xiaojun Xia

  2. VIP Region, Sun Yat-sen University Cancer Center, Guangzhou, China

    Wenzhuo He

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  1. Wenzhuo He
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  2. Wenjing Xiong
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Correspondence to Xiaojun Xia .

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  1. School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Jun Cui

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He, W., Xiong, W., Xia, X. (2019). Autophagy Regulation of Mammalian Immune Cells. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_2

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