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Autophagy, Aging, and Longevity

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Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1206))

Abstract

Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. Enhanced autophagy can delay aging and prolong life span. The absence of autophagy leads to the accumulation of mutant and misfolded proteins in the cell, which is the basis for the emergence and development of neurodegenerative diseases and other aging-related diseases. It will be of importance to develop approaches to extend the lifespan and improve the health of elderly individuals through the modulation of autophagy.

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Abbreviations

CMA:

Chaperone-mediated autophagy

FOXO3a:

Forkhead transcription factor

HSP70:

Heat shock protein 70

IGF-1:

Insulin-like growth factor 1

LAMP2a:

Lysosome-associated membrane protein type 2a

LC3:

Microtubule-associated protein 1 light chain 3

Nrf2:

NF-related nuclear factor

SAMP8:

Senescence-accelerated mouse P8

TOR:

Target of rapamycin

TSC1:

Tuberous sclerosis complex 1

ULK1:

Unc-51-like autophagy activating kinase 1

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Author information

Authors and Affiliations

  1. School of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China

    Li Luo

  2. Jiangsu Key Laboratory of Neuropsychiatric Diseases, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, College of Pharmaceutical Sciences of Soochow University, Suzhou, China

    Zheng-Hong Qin

Authors
  1. Li Luo
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  2. Zheng-Hong Qin
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Correspondence to Zheng-Hong Qin .

Editor information

Editors and Affiliations

  1. Jiangsu Key Laboratory of Neuropsychiatric Diseases, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, College of Pharmaceutical Sciences of Soochow University, Suzhou, China

    Zheng-Hong Qin

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Luo, L., Qin, ZH. (2019). Autophagy, Aging, and Longevity. In: Qin, ZH. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1206. Springer, Singapore. https://doi.org/10.1007/978-981-15-0602-4_24

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