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Exposomics: The Exposome in Early Life

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Health Impacts of Developmental Exposure to Environmental Chemicals

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Abstract

Individuals are exposed to a wide range of environmental factors of different nature, social, physical, and chemical over their lifetime. The cumulative effect of these environmental stressors, their interaction with genetic factors and key susceptible developmental stages determines disease risks. The concept of the “exposome”—representing all non-genetic exposures experienced during the life course—was a call to complement the impressive advances made in measuring the human genome with similar technology investment in measuring the environmental component of disease aetiology (Wild, Cancer Epidemiol Biomark Prev 14:1847–1850, 2005). While measuring the exposome is recognized to be extremely challenging due to its dynamic, heterogeneous, and still unknown nature, advances in new and emerging technologies were seen as opportunities to characterize internal and external domains of the exposome in a more holistic way. More than a decade after the exposome concept was first proposed, several projects across Europe and the USA have started implementing at least part of it. This chapter will describe the utility of the exposome concept, its characteristics, how it can be feasibly measured, and its first implementation in health studies, focusing on the early-life periods. Finally, the challenges and future perspectives of exposome research will be presented.

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Authors and Affiliations

  1. ISGlobal, Barcelona, Spain

    Léa Maitre & Martine Vrijheid

  2. Universitat Pompeu Fabra (UPF), Barcelona, Spain

    Léa Maitre & Martine Vrijheid

  3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

    Léa Maitre & Martine Vrijheid

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  1. Léa Maitre
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  2. Martine Vrijheid
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Correspondence to Léa Maitre .

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  1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

    Reiko Kishi

  2. Department of Environmental Health Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Philippe Grandjean

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Maitre, L., Vrijheid, M. (2020). Exposomics: The Exposome in Early Life. In: Kishi, R., Grandjean, P. (eds) Health Impacts of Developmental Exposure to Environmental Chemicals. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-0520-1_18

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  • DOI: https://doi.org/10.1007/978-981-15-0520-1_18

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