Abstract
Fundus complications due to pathologic myopia are a major cause of visual impairment and blindness worldwide, especially in East Asian countries. The patients with pathologic myopia develop loss of the best-corrected vision due to various lesions occurring in the macula and the optic nerve. In the META-PM (meta analyses of pathologic myopia) study classification, pathologic myopia has been defined by the presence of myopic chorioretinal atrophy equal to or more serious than diffuse atrophy and/or the presence of posterior staphyloma. In addition, the advent of new imaging technologies, such as optical coherence tomography (OCT), ultra wide-field OCT, and three-dimensional magnetic resonance imaging (3D MRI) has enabled the detailed observation of various pathologies specific to pathologic myopia. In addition, new pathology such as dome-shaped macula has been clarified. Therapeutic approaches such as intravitreal injections of anti-vascular endothelial growth factor agents and the vitreoretinal surgeries for myopic macular retinoschisis have greatly improved the prognosis of patients with pathologic myopia. In the future, therapies targeting staphylomas are expected.
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Keywords
FormalPara Key Points-
Pathologic myopia is defined by the presence of posterior staphylomas and/or the presence of myopic chorioretinal atrophy equal to or more serious than diffuse atrophy.
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Myopic CNV is the most frequent cause of central vision loss.
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Ultra wide-field OCT is a useful tool to detect posterior staphylomas.
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Anti-VEGF therapies have greatly improved the prognosis of myopic CNV.
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Vitreoretinal surgeries for myopic macular retinoschisis are useful.
9.1 Introduction
Pathologic myopia (PM) is a major cause of blindness in the world, especially in East Asian countries [1,2,3,4,5]. The cause of blindness in patients with PM includes myopic maculopathy with or without posterior staphyloma, myopic macular retinoschisis, and glaucoma or glaucoma-like optic neuropathy. In this chapter, the lesions of myopic fundus complications including posterior staphylomas are described.
9.2 Definition of Pathologic Myopia
The terms “pathologic myopia,” “high myopia,” and “axial myopia” have long been used in a parallel manner in the literature. According to recent discussions, the term “high myopia” simply describes the status of a “high degree of myopia” and should be defined by a cut-off value of myopic refractive error. The term “axial myopia” may be used to describe the situation with an axial elongation as cause for the myopic refractive error. It is in contrast to the term refractive myopia, which is used for eyes with an abnormally high refractive power of their optical media. The term “pathologic myopia” describes the situation of pathologic consequences of a myopic axial elongation. According to a recent consensus article by Ohno-Matsui et al. [6], pathologic myopia was defined by myopic chorioretinal atrophy equal to or more serious than diffuse atrophy (by META-PM study group classification [7]) and/or the presence of posterior staphylomas.
9.3 Posterior Staphyloma
Posterior staphyloma has been considered a hallmark lesion of pathologic myopia. While axial elongation may primarily start in the equatorial and retro-equatorial region with secondary changes taking place at the posterior fundus, posterior staphylomas occur in the posterior segment of the eye and can be associated with, or lead to, vision-threatening complications in the macula as part of a myopic maculopathy [7,8,9,10,11] and myopic optic neuropathy/glaucoma [12, 13].
9.3.1 Definition of Staphyloma by Spaide (Fig. 9.1)
A posterior staphyloma is an outpouching of a circumscribed area of the posterior fundus, where the radius of curvature is less than the curvature radius of the surrounding eye wall [14].
Definition of posterior staphyloma (cited from the textbook Pathologic Myopia [14]). (a) Normal eye shape. (b) Axial expansion occurring in the equatorial region that does not induce any altered curvature in the posterior aspect of the eye. This eye would have axial myopia but no staphyloma. (c) Posterior staphyloma. A second curvature occurs in the posterior portion of the eye, and this second curvature has a small radius (r 2) than the surrounding eye wall (r 1). This secondary curve is a staphyloma. (This figure does not take into account changes in scleral thickness)
9.3.2 Detection of Posterior Staphyloma
Moriyama et al. recently applied three-dimensional magnetic resonance imaging (3D-MRI) to analyze the shape of the entire eye from the corneal surface to the posterior pole including even large posterior staphylomas (Fig. 9.2) [15,16,17]. The technique allowed visualizing a staphyloma from any angle. The advantage of 3D-MRI of visualizing the shape of the whole eye including the anterior ocular segment is combined with its disadvantage of not being feasible as a screening technique. Instead, a new prototype of a wide-field swept-source optical coherence tomographic (OCT) system has been developed, which uses not only one but multiple scan lines and which generates scan maps allowing a three-dimensional reconstruction of posterior staphylomas in a region of interest of 23 × 20 mm with a depth of 5 mm. Applying a wide-field OCT (WF-OCT), Shinohara et al. [18] showed that WF-OCT could provide tomographic images of posterior staphylomas in a resolution and size unachievable up to that time, and that WF-OCT might replace 3D-MRI in examining posterior staphylomas. Upon WF-OCT, the edges of the staphylomas showed consistent features, consisting of a gradual thinning of the choroid from the periphery toward the staphyloma edge and a gradual re-thickening of the choroid from the staphyloma edge in direction to the posterior pole (Fig. 9.3).
Swept-source wide-field optical coherence tomographic (OCT) image of a posterior staphyloma. (Left) Right fundus shows a wide staphyloma (arrowheads). (Right) The wide-field OCT image shows the staphyloma edge (arrow) with a gradual thinning of the choroid from the periphery toward the staphyloma edge and a gradual re-thickening of the choroid toward the posterior pole. The white arrow indicates the change in the curvature radius of the sclera at the staphyloma edge
An additional advantage of the swept-source WF-OCT technology was the relatively large depth of focus so that structures from the posterior vitreous to the sclera could be imaged in the same image. It allowed the analysis of relationships between vitreoretinal abnormalities and other lesions in the inner retinal layers, such as myopic macular retinoschisis and posterior staphylomas as reported by Shinohara et al. [19] (Fig. 9.4).
Spatial relationship between myopic macular retinoschisis and posterior staphyloma. In this swept-source wide-field optical coherence tomographic image, the outer and inner retinoschisis is restricted to the area of the posterior staphyloma. It may suggest that the inner retinal structures as compared to the outer retinal structures were not flexible enough to follow the elongated circumference of Bruch’s membrane and sclera
9.3.3 Classification (Ohno-Matsui’s Modified Classification, Fig. 9.3)
Based upon and modifying Curtin’s [20] classical categorization of posterior staphylomas, with Types I–V as primary staphylomas and Types VI–X as compound staphylomas, Ohno-Matsui [17] used 3D-MRI and wide-field fundus imaging to reclassify staphylomas into six types: the wide macular type, the narrow macular type, the peripapillary type, the nasal type, the inferior type, and others (Fig. 9.5).
Classification staphyloma (cited from [17] with permission). New classification of posterior staphyloma according to its location and extent. The staphyloma type is renamed according to its location and distribution. Type I → wide, macular staphyloma, Type II → narrow, macular staphyloma, Type III → peripapillary staphyloma, Type IV → nasal staphyloma, Type V → inferior staphyloma, others → staphylomas other than Types I–V
9.4 Fundus Complications of Pathologic Myopia
9.4.1 Myopic Chorioretinal Atrophy (META-PM Study, Table 9.1)
In the META-PM classification [7], myopic maculopathy lesions have been categorized into five categories from “no myopic retinal lesions” (Category 0), “tessellated fundus only” (Category 1; Fig. 9.6a), “diffuse chorioretinal atrophy” (Category 2; Fig. 9.6b), “patchy chorioretinal atrophy” (Category 3; Fig. 9.6c), to “macular atrophy” (Category 4; Fig. 9.6d). These categories were defined based on long-term clinical observations that showed the progression patterns and associated factors of the development of myopic choroidal neovascularization (CNV) for each stage. Three additional features were added to these categories and were included as “plus signs”: (1) lacquer cracks (Fig. 9.6e) and (2) myopic CNV (Fig. 9.6f) (Table 9.1). Since a Fuchs’ spot represented a scarred form of myopic CNV, Fuchs’ spots were categorized under the term of myopic CNV. The reason for separately listing the “plus signs” was that all three lesions have been shown to be strongly associated with central vision loss; however, they did not fit into any particular category and might develop from, or coexist, in eyes with any of the myopic maculopathy categories described above. Based on this classification, pathologic myopia has now been defined as myopic maculopathy Category 2 or above, or the presence of “plus” sign or posterior staphyloma [7, 21].
Myopic maculopathy. (a) Fundus tessellation temporal to the optic disc. (b) Diffuse chorioretinal atrophy. Ill-defined, yellowish atrophy is seen in the posterior fundus. (c) Patchy chorioretinal atrophy. Within the area of diffuse atrophy, multiple areas of well-defined, whitish atrophic lesions are seen (arrows); yellow arrows: parapapillary gamma zone; red arrow: parapapillary delta zone. (d) Macular atrophy, several years after the formation of myopic choroidal neovascularization (CNV), a well-defined atrophic lesion is seen in the macular area. (e) Myopic CNV. Subretinal hemorrhage is seen around the CNV (arrow); yellow arrows: parapapillary gamma zone; red arrow: parapapillary delta zone. (f) Lacquer cracks. Multiple yellowish linear lesions are seen (arrows)
9.4.2 Diffuse Chorioretinal Atrophy (Category 2)
Diffuse chorioretinal atrophy is characterized by a yellowish white appearance of the posterior pole. The region of the diffuse atrophy may extend from a restricted area around the optic disc and a part of the macula to the entire posterior pole. The atrophy generally first appears around the optic disc, often increases with age, and finally covers the entire area within a staphyloma if a staphyloma is present. Both older age and longer axial length have been described as risk factors for the development of diffuse atrophy [9]. Marked thinning of the choroidal layer in the area of diffuse atrophy can be detected upon OCT, with occasional large choroidal vessels remaining.
9.4.3 Patchy Chorioretinal Atrophy (Category 3)
Patchy chorioretinal atrophy appears as well-defined, grayish white lesion(s) in the macular area or around the optic disc. Upon OCT, the area of patchy atrophy is characterized by the absence of the entire choroid and the RPE as well as of the outer retina. Hyper-transmission through the underlying sclera can be seen upon OCT. Using swept-source OCT, Ohno-Matsui et al. [22] showed that patchy atrophy was not simply a chorioretinal atrophy but was combined with a defect in Bruch’s membrane (BM).
9.4.4 Lacquer Cracks (Plus Sign)
Lacquer cracks appear as yellowish linear lesions in the macula. Lacquer cracks have been considered to represent breaks in BM [9, 23,24,25]. Progression patterns of lacquer cracks include an increased number, elongation, and progression to patchy atrophy [8, 26].
Detection of lacquer cracks can sometimes be difficult especially in eyes with diffuse atrophy. Assessments of hyper-fluorescence by fluorescein angiography and hypo-fluorescence upon indocyanine green angiography have been useful for the diagnosis. Other linear lesions due to pathologic myopia with a similar hypo-fluorescence upon by indocyanine green angiography, such as myopic stretch lines, have to be differentiated [27].
Due to their small width, linear defects in BM as the base of lacquer cracks are difficult to be directly detected. Instead, hyper-reflective lines of the choroidal and scleral tissue layers on the OCT images indirectly indicate the linear BM defect by an optical window effect (Fig. 9.7). The recently developed imaging technique of OCT angiography may be useful for detecting a rupture of the choriocapillaris in the area of lacquer cracks, again indirectly indicating a defect in BM [28]. Since a subretinal bleeding can often be observed at the onset of the development of lacquer cracks [29,30,31] (Fig. 9.8), it is important to exclude the presence of a myopic CNV in cases of subretinal bleeding in the region of lacquer cracks.
Multimodal imaging of lacquer cracks. (a) Left fundus shows lacquer crack as yellowish linear lesion (arrow). (b) Fluorescein angiogram shows linear hyper-fluorescence at the site of lacquer crack (arrow). (c) Optical coherent tomographic image shows deep penetration of light (arrows) at the site of lacquer cracks. (d) OCT angiography shows a defect of choriocapillaris (arrows)
9.4.5 Myopic CNV and CNV-Related Macular Atrophy
Myopic CNV is a major sight threatening complication of pathologic myopia. It is the most common cause of CNV in individuals younger than 50 years, and it is the second most common cause of CNV overall [25, 32]. Myopic CNV is a Type II CNV and shows a clear hyper-fluorescence by fluorescein angiography. Anti-VEGF therapy is the first-line treatment for myopic CNV, as shown by the RADIANCE study [33] and the MYRROR study [34].
In the long-term, both in treated eyes and in eyes exposed to the natural course of the disorder, macular atrophy develops around the scarred CNV and impairs central vision (Fig. 9.9). Swept-source OCT showed that CNV-related macular atrophy was not simply a chorioretinal atrophy but was BM hole [35], like patchy chorioretinal atrophy.
Fundus photographs showing various phases of myopic CNV in different eyes. (a) Active phase. Subretinal bleeding is observed around the grayish CNV (black arrow). (b) Scar phase with pigmented scarred CNV (black arrow). (c) Atrophic phase at about 10 years after the first occurrence of a CNV; a well-defined macular atrophy (green arrows) appears as a macular Bruch’s membrane defect, merging with a large parapapillary gamma zone (yellow arrows) around a parapapillary delta zone (red arrows)
As shown upon OCT-angiography, the CNV maintains its blood flow even when the CNV transforms into the scar phase, including the area of CNV-related macular atrophy (Fig. 9.10). Louzada et al. [36] and Giuffre et al. [37] reported that blood vessels originating from the sclera were found at the site of myopic CNVs. Recently Ishida et al. [38] reported that the blood vessels of myopic CNVs were continuous to scleral branches of short posterior ciliary arteries (Fig. 9.11).
Detection of choroidal neovascularization (CNV) with blood flow in all of the three phases of myopic CNV by optical coherent tomographic angiography (OCTA) [38]. (a–d) Active phase. Right fundus shows a grayish CNV (arrow in a). Fluorescein angiography (FA) shows hyper-fluorescence at the CNV (arrow in b). (c) Type II CNV is observed as subretinal tissue with fuzzy border by OCT. (d) OCTA shows newly formed vessels. (e–h) Scar phase. (e) Left fundus shows irregular shape of CNV. (f) FA shows tissue staining of irregular shape of CNV. (g) OCT shows subretinal CNV with sharp margins. (h) OCTA shows spiky shaped CNV. (i–l) Atrophic phase. CNV-related macular atrophy (margined by arrowheads) is seen around the remnants of a CNV (arrow in i). Fundus autofluorescence shows clear hypo-fluorescence in the area of the macular atrophy around the CNV (arrow in j). OCT shows subretinal CNV (arrow in k) surrounded by a large defect of Bruch’s membrane. The inner retina directly sits on the sclera in the area of macular atrophy. The choroid is barely seen in the area of the macular atrophy. (l) OCTA shows CNV with blood flow. Large blood vessels appear to be connected to the CNV
Continuity between scleral perforating vessels and myopic choroidal neovascularization (CNV) in the atrophic phase [38]. (a) Fundus photograph of the right eye shows a sharp-margined macular atrophy around a CNV (arrow). Arrows indicate scanned line by OCT. (b, c) Swept-source OCT images show subretinal CNV. Cross sections of blood vessels coursing within the sclera can be seen (arrows in c) in a section scanned by swept-source OCT (blue arrow in a). In a serial OCT section (b, in a section scanned at white arrow in a), this vessel (arrows) is observed to be continuous with the CNV through a defect of Bruch’s membrane (between arrowheads). (d, e) OCT angiogram shows the intrascleral vessel in Fig. 9.4b begins to be seen at the depth just posterior to the CNV (arrows, d). At a deeper slab e, the longer course of this vessel is seen (arrow, e). (f, g) Arterial phase of ICG angiogram (6 s after dye injection in f, and 8 s after dye injection in g) shows that the intrascleral vessel shown in OCT angiogram and OCT b scans was already filled with dye in the arterial phase (arrows). (h) Arterial phase of fluorescein angiogram (10 s after dye injection) shows that the intrascleral vessel observed in f and g is fairly seen (arrows)
9.5 Myopic Macular Retinoschisis
Using optical coherence tomography, Takano and Kishi first demonstrated a foveal retinal detachment and retinoschisis in severely myopic eyes with posterior staphylomas [39]. Panozzo and Mercanti proposed the term “myopic traction maculopathy (MTM)” to encompass various findings characterized by a traction as visualized by OCT in highly myopic eyes [40]. Myopic traction maculopathy, also called foveal retinoschisis [39], macular retinoschisis [41], or myopic foveoschisis [42], includes the features of schisis-like inner retinal fluid, schisis-like outer retina fluid, foveal detachment, lamellar or full-thickness macular hole, and/or macular detachment [43]. These features can best be detected by OCT as an indispensable tool to diagnose MTM. Additional examination techniques are a retro-mode imaging which uses an infrared laser in the confocal scanning laser ophthalmoscope and which can produce a pseudo-three-dimensional image showing the details of deep retinal structures (Fig. 9.12). Applying retro-mode imaging, a characteristic fingerprint and firework pattern at the corresponding area of a macular retinoschisis have been detected in the region of a macula retinoschisis [44, 45].
Myopic macular retinoschisis. (a) OCT image shows outer and inner retinoschisis. (b) Columnar structures are seen within the area of outer retinoschisis (cited from [44]). Retro-mode image by F10 (Nidek, Aichi, Japan) showing a fingerprint pattern (black arrowheads) consisting of central radiating retinal striae and surrounding multiple dots (arrowhead) and lines (arrow). Many lines appear in parallel or in a whorled pattern. The inner lamellar hole appears as a circular defect at the central fovea
Shimada et al. have classified myopic traction maculopathy according to its location and extent from S0 through S4: S0: no retinoschisis; S1: extrafoveal; S2: foveal; S3: both foveal and extrafoveal but not the entire macula; and S4: entire macula [46].
9.6 Dome-Shaped Macula (DSM)
A dome-shaped macula (DSM) is an inward protrusion of the macula as visualized by OCT (Fig. 9.13) [58,59,49]. Imamura et al. reported that a DSM was associated with, and caused by, a local thickening of the subfoveal sclera [50]. It was postulated that the local thickening of the subfoveal sclera was an adaptive or compensatory response to the defocus of the image on the fovea in highly myopic eyes. Fang et al. [51] found the high prevalence of macular BM defects around the dome (Figs. 9.14 and 9.15). Ohno-Matsui et al. reported a similar finding [52] as peri-dome choroidal deepening. The morphology of the DSM in association with macular BM defects may be associated with a focal relaxation of the posterior sclera, no longer pushed outward by an expanding BM but allowed to partially bulge inward, leading to the formation of a DSM.
Various types of Dome-shaped macula (DSM). (a) Serous retinal detachment is seen on the top of the dome. The sclera is too thick to allow the visualization of its outer surface. (b) The subfoveal sclera is thick; however, the scleral outer surface is visible in the surrounding area. (c) The subfoveal sclera is thick; however, the scleral outer surface is visible in all regions
Dome-shaped macula (DSM) coexisting with the macular Bruch’s membrane defects (MBMD) associated with patchy atrophy [51]. (a) Left fundus of a 65-year-old woman with an axial length of 33.2 mm shows multiple patches of whitish, well-defined patchy atrophy in the regions superior and inferior to the fovea. Two long arrows show scanned lines examined by optical coherence tomography (OCT) in the images (b) and (c), respectively. (b) Oblique OCT section across the fovea demonstrates an inward protrusion due to DSM. Bruch’s membrane is present at the center of the macula, but is interrupted abruptly (arrow) on both sides of the dome. (c) Oblique OCT section across the fovea shows the inward protrusion of macula due to DSM. Bruch’s membrane is present at the center of macula, but is abruptly interrupted (arrow) on both sides of the dome. The remnants of Bruch’s membrane are seen near the edge of the macular Bruch’s membrane defect (arrowheads)
Severe deformity of the optic disc due to pathologic myopia. (a) Acquired megalodisc. The optic disc shows irregular shape. (b) Horizontally stretched optic disc. (c) Extreme tilting of the optic disc. Black arrows: peripapillary rim; red arrows: parapapillary delta zone; green arrows: parapapillary gamma zone
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Ohno-Matsui, K., Jonas, J.B. (2020). Understanding Pathologic Myopia. In: Ang, M., Wong, T. (eds) Updates on Myopia. Springer, Singapore. https://doi.org/10.1007/978-981-13-8491-2_9
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DOI: https://doi.org/10.1007/978-981-13-8491-2_9
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