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Role of MMPs and Oxidants in Lung Diseases

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Oxidative Stress in Lung Diseases

Abstract

The lung matrix consists of numerous extracellular matrix (ECM) proteins and glycoproteins including collagens, elastin, fibronectin, laminin, heparin, and sulfated proteoglycans. Matrix metalloproteinases (MMPs) play a pivotal role in the remodeling of ECM and is central in lung organogenesis. Although not all MMPs are found in the lung matrix, there is considerable evidence that few MMPs are up- and/or downregulated during acute and chronic diseases of the lungs. The association of alveolar ECM is related in chronic inflammatory lung diseases like idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis (CF) which have been investigated extensively. IPF is associated with production, deposition, and remodeling of the ECM, whereas COPD is characterized by a loss of the same. MMPs target the structural ECM proteins, cell adhesion molecules, growth factors, cytokines, and chemokines that play role in the genesis and development of chronic lung diseases. The association between MMPs and lung cancer has been long documented although the precise role of MMPs in lung cancer remains unanswered. Herein, we have discussed the role of MMPs along with oxidants in the pathogenesis of chronic lung diseases, cancer, and their potential as targets for therapy.

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References

  • Agrawal A, Mabalirajan U (2016) Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria. Am J Physiol Lung Cell Mol Physiol 310:L103–L113

    Article  PubMed  Google Scholar 

  • Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A, Kurosky A, Sur S, Boldogh I (2009) Mitochondrial dysfunction increases allergic airway inflammation. J Immunol 183:5379–5387

    Article  CAS  PubMed  Google Scholar 

  • Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari BK, Jha KA, Barhanpurkar AP, Wani MR, Roy SS, Mabalirajan U, Ghosh B, Agrawal A (2014) Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J 33:994–1010

    CAS  PubMed  PubMed Central  Google Scholar 

  • Atlante A, Favia M, Bobba A, Guerra L, Casavola V, Reshkin SJ (2016) Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function. J Bioenerg Biomembr 48(3):197–210

    Article  CAS  PubMed  Google Scholar 

  • Baker AH, Edwards DR, Murphy G (2002) Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115:3719–3727

    Article  CAS  PubMed  Google Scholar 

  • Bergeron C, Page N, Joubert P, Barbeau B, Hamid Q, Chakir J (2003) Regulation of procollagen I (alpha 1) by interleukin-4 in human bronchial fibroblasts: a possible role in airway remodeling in asthma. Clin Exp Allergy 33:1389–1397

    Article  CAS  PubMed  Google Scholar 

  • Bezerra FS, Valenca SS, Pires KM, Lanzetti M, Pimenta WA, Schmidt AC, Porto LC, Zin WA (2011) Long–term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in mice. Respir Physiol Neurobiol 177:120–126

    Article  CAS  PubMed  Google Scholar 

  • Black RA, White JM (1998) ADAMs: focus on the protease domain. Curr Opin Cell Biol 10(5):654–659

    Article  CAS  PubMed  Google Scholar 

  • Bosse M, Chakir J, Rouabhia M, Boulet LP, Audette M, Laviolette M (1999) Serum matrix metalloproteinase-9: tissue inhibitor of metalloproteinase-1 ratio correlates with steroid responsiveness in moderate to severe asthma. Am J Respir Crit Care Med 159:596–602

    Article  CAS  PubMed  Google Scholar 

  • Boulay ME, Prince P, Deschesnes F, Chakir J, Boulet LP (2004) Metalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic response. Respiration 71:216–224

    Article  CAS  PubMed  Google Scholar 

  • Bousquet J, Chanez P, Lacoste JY, White R, Vic P, Godard P, Michel FB (1992) Asthma—a disease remodeling the airways. Allergy 47:3–11

    Article  CAS  PubMed  Google Scholar 

  • Braber S, Overbeek SA, Koelink PJ, Henricks PA, Zaman GJ, Garssen J, Kraneveld AD, Folkerts G (2011) CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. Eur J Pharmacol 668:443–449

    Article  CAS  PubMed  Google Scholar 

  • Cataldo D, Munaut C, Noel A, Frankenne F, Bartsch P, Foidart JM, Louis R (2000) MMP-2-and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol 123:259–267

    Article  CAS  PubMed  Google Scholar 

  • Cataldo D, Munaut C, Noel A, Frankenne F, Bartsch P, Foidart JM, Louis R (2001) Matrix metalloproteinases and TIMP-1 production by peripheral blood granulocytes from COPD patients and asthmatics. Allergy 56:145–151

    Article  CAS  PubMed  Google Scholar 

  • Cataldo D, Gueders M, Noel A, Foidart JM, Bartsch P, Louis R (2002a) Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) mRNA transcripts in the bronchial secretions of asthmatics and COPD. Lab Investig 84:418–424

    Article  CAS  Google Scholar 

  • Cataldo DD, Tournoy KG, Vermaelen K, Munaut C, Foidart JM, Louis R, Noel A, Pauwels RA (2002b) Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyper responsiveness during allergen-induced airway inflammation. Am J Pathol 161:491–498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cataldo DD, Gueders MM, Rocks N, Sounni NE, Evrard B, Bartsch P, Louis R, Noel A, Foidart JM (2003) Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors. Cell Mol Biol 49:875–884

    CAS  PubMed  Google Scholar 

  • Chetty C, Bhoopathi P, Joseph P, Chittivelu S, Rao JS, Lakka S (2006) Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice. Mol Cancer Ther 5:2289–2299

    Article  CAS  PubMed  Google Scholar 

  • Chuang SS, Hung CH, Hua YM, Tien CH, Yang KD, Jong YJ, Hsu SH, Lin CS (2007) Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma. Pediatr Int 49(6):918–922

    Article  CAS  PubMed  Google Scholar 

  • Churg A, Wang X, Wang RD, Meixner SC, Pryzdial EL, Wright JL (2007a) Alpha1-antitrypsin suppresses TNF-a and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol 37:144–151

    Article  CAS  PubMed  Google Scholar 

  • Churg A, Wang R, Wang X, Onnervik PO, Thim K, Wright JL (2007b) Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax 62:706–713

    Article  PubMed  PubMed Central  Google Scholar 

  • Churg A, Zhou S, Wright JL (2012) Series “Matrix metalloproteinases in lung health and disease”: matrix metalloproteinases in COPD. Eur Respir J 39:197–209

    Article  CAS  PubMed  Google Scholar 

  • Corbel M, Caulet-Maugendre S, Germain N, Molet S, Lagente V, Boichot E (2001) Inhibition of bleomycin induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat. J Pathol 193:538–545

    Article  CAS  PubMed  Google Scholar 

  • Correa A, Trojanek JB, Diemer S, Mall MA, Schultz C (2009) Membrane-bound FRET probe visualizes MMP-12 activity in pulmonary inflammation. Nat Chem Biol 5(9):628–630

    Article  CAS  Google Scholar 

  • Coultas DB, Zumwalt RE, Black WC, Sobonya RE (1994) The epidemiology of interstitial lung disease. Am J Respir Crit Care Med 150:967–972

    Article  CAS  PubMed  Google Scholar 

  • Craig VJ, Zhang L, Hagood JS, Owen CA (2015) Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 53:585–600

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crouch E (1990) Pathobiology of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 259:L-159–LL184

    Article  CAS  Google Scholar 

  • Dasilva AG, Yong VW (2008) Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro. J Neuroimmunol 199(1–2):24–34

    Article  CAS  PubMed  Google Scholar 

  • Davey A, McAuley DF, O’Kane CM (2011) Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair. Eur Respir J 38:959–970

    Article  CAS  PubMed  Google Scholar 

  • Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM (2008) Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood 112:3455–3464

    Article  CAS  PubMed  Google Scholar 

  • Delacourt C, Le Bourgeois M, D’Ortho MP, Doit C, Scheinmann P, Navarro J, Harf A, Hartmann DJ, Lafuma C (1995) Imbalance between 95 kDa type IV collagenase and tissue inhibitor of metalloproteinases in sputum of patients with cystic fibrosis. Am J Respir Crit Care Med 152(2):765–774

    Article  CAS  PubMed  Google Scholar 

  • Demedts IK, Brusselle GG, Bracke KR, Vermaelen KY, Pauwels RA (2005) Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol 5:257–263

    Article  CAS  PubMed  Google Scholar 

  • El-Badrawy MK, Yousef AM, Shaalan D, Elsamanoudy AZ (2014) Matrix metalloproteinase-9 expression in lung cancer patients and its relation to serum mmp-9 activity, pathologic type, and prognosis. J Bronchol Interv Pulmonol 21:327–334

    Article  Google Scholar 

  • Fujita M The role of MMPs in the progression of chronic lung inflammatory diseases, lung inflammation Kian Chung Ong, Intech Open, May 14th 2014

    Google Scholar 

  • Gaggar A, Li Y, Weathington N, Winkler M, Kong M, Jackson P, Blalock JE, Clancy JP (2007) Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients. Am J Physiol Lung Cell Mol Physiol 293(1):L96–L104

    Article  CAS  PubMed  Google Scholar 

  • Gaggar A, Jackson PL, Noerager BD, O’Reilly PJ, McQuaid DB, Rowe SM, Clancy JP, Blalock JE (2008) A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J Immunol 180(8):5662–5669

    Article  CAS  PubMed  Google Scholar 

  • Ghada MM, Mohamed NF, Mahmoud H (2012) Interplay between matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in acute asthma exacerbation and airway remodeling. Egypt J Chest Dis Tuberc 16:35–39

    Google Scholar 

  • Giannandrea M, Parks WC (2014) Diverse functions of matrix metalloproteinases during fibrosis. Dis Model Mech 7:193–203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gifford JR, Trinity JD, Kwon OS, Layec G, Garten RS, Park SY, Nelson AD, Richardson RS (2018) Altered skeletal muscle mitochondrial phenotype in COPD: disease vs. disuse. J Appl Physiol (1985) 124:1045–1053

    Article  CAS  Google Scholar 

  • Gomis-Ruth FX (2009) Catalytic domain architecture of metzincin metalloproteases. J Biol Chem 284(23):15353–15357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gosselink JV, Hayashi S, Elliott WM, Xing L, Chan B, Yang L et al (2010) Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181:1329–1335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han Z, Jun XU, Zhong N (2003) Expression of matrix metalloproteinases MMP-9 within the airways in asthma. Respir Med 97:563–567

    Article  CAS  PubMed  Google Scholar 

  • Harju T, Kinnula VL, Paakko P, Salmenkivi K, Juha Risteli J, Kaarteenaho R (2010) Variability in the precursor proteins of collagen I and III in different stages of COPD. Respir Res 11:165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD (1997) Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277:2002–2004

    Article  CAS  PubMed  Google Scholar 

  • Houghton AM (2015) Matrix metalloproteinases in destructive lung disease. Matrix Biol 44–46:167–174

    Article  PubMed  CAS  Google Scholar 

  • Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, Cornelius LA, Shapiro SD (2006) Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res 66:6149–6155

    Article  CAS  PubMed  Google Scholar 

  • Ichiyasu H, McCormack JM, McCarthy KM, Dombkowski D, Preff er FI, Schneeberger EE (2004) Matrix metalloproteinase-9-deficient dendritic cells have impaired migration through tracheal epithelial tight junctions. Am J Respir Cell Mol Biol 30(6):761–770

    Article  CAS  PubMed  Google Scholar 

  • Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, Rowlands DJ, Quadri SK, Bhattacharya S, Bhattacharya J (2012) Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 18:759–765

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jackson PL, Xu X, Wilson L, Weathington NM, Clancy JP, Blalock JE, Gaggar A (2010) Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction. Mol Med 16(5–6):159–166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jana S, Chatterjee K, Ray AK, Dasmahapatra P, Swarnakar S (2016) Regulation of matrix metalloproteinases- 2 activity by Cox-2-PGE2-Pakt axis promotes angiogenesis in endometriosis. PLoS One 11(10):e0163540

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jeffery PK (2001) Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 164(10. Pt 2):S28–S38

    Article  CAS  PubMed  Google Scholar 

  • Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES (2017) ATS assembly on respiratory cell and molecular biology. An official American thoracic society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis. Am J Respir Cell Mol Biol 56:667–679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johnson S, Knox A (1999) Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am J Physiol Lung Cell Mol Physiol 277:L1109–L1117

    Article  CAS  Google Scholar 

  • Kang MJ, Shadel GS (2016) A mitochondrial perspective of chronic obstructive pulmonary disease pathogenesis. Tuberc Respir Dis (Seoul) 79:207–213

    Article  Google Scholar 

  • Katzenstein ALA, Myers JL (1998) Idiopathic pulmonary fibrosis. Clinical relevance of pathologic classification. Am J Respir Crit Care Med 157:1301–1315

    Article  CAS  PubMed  Google Scholar 

  • Kelly EAB, Busse WW, Jarjour NN (2000) Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med 162:1157–1161

    Article  CAS  PubMed  Google Scholar 

  • Killar L, White J, Black R, Peschon J (1999) Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE). Ann N Y Acad Sci 878:442–452

    Article  CAS  PubMed  Google Scholar 

  • Ko FWS, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG (2005) A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion. Chest 27:1919–1927

    Article  Google Scholar 

  • Kochanek K, Xu J, Murphy S, Miniño A, Kung H (2011) Deaths: final data for 2009. Natl Vital Stat Rep 60:3–11

    Google Scholar 

  • Lagente V, Le Quement C, Boichot E (2009) Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases. Expert Opin Ther Targets 13:287–295

    Article  CAS  PubMed  Google Scholar 

  • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G (1998) A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339:1194–1200

    Article  CAS  PubMed  Google Scholar 

  • Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K (2005) Interleukin-1b causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 32:311–318

    Article  CAS  PubMed  Google Scholar 

  • Lasky JA, Brody AR (2000) Interstitial fibrosis and growth factors. Environ Health Prospect 108:S761–S762

    Google Scholar 

  • Li L, Mei TH, Zhou XD, Zhang XG (2009) Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer. Ai Zheng 28:60–63

    PubMed  Google Scholar 

  • Loffek S, Schilling O, Franzke CW (2011) Series “Matrix metalloproteinases in lung health and disease”: biological role of matrix metalloproteinases: a critical balance. Eur Respir J 38:191–208

    Article  CAS  PubMed  Google Scholar 

  • Mabalirajan U, Ghosh B (2013) Mitochondrial dysfunction in metabolic syndrome and asthma. J Allergy (Cairo) 2013:340476

    Google Scholar 

  • Mabalirajan U, Dinda AK, Kumar S, Roshan R, Gupta P, Sharma SK, Ghosh B (2008) Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J Immunol 181:3540–3548

    Article  CAS  PubMed  Google Scholar 

  • Mabalirajan U, Dinda AK, Sharma SK, Ghosh B (2009) Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model. J Immunol 183(3):2059–2067

    Article  CAS  PubMed  Google Scholar 

  • Malik M, Bakshi CS, McCabe K, Catlett SV, Shah A, Singh R, Jackson PL, Gaggar A, Metzger DW, Melendez JA, Blalock JE, Sellati TJ (2007) Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis. J Immunol 178:1013–1020

    Article  CAS  PubMed  Google Scholar 

  • Mannam P, Srivastava A, Sugunaraj JP, Lee PJ, Sauler M (2014) Oxidants in acute and chronic lung disease. J Blood Lymph 4:1000128

    Article  PubMed  PubMed Central  Google Scholar 

  • Martinet Y, Menard O, Vaillant P, Vignaud JM, Martinet N (1996) Cytokines in human lung fibrosis. Arch Toxicol Suppl 18:127–139

    Article  CAS  PubMed  Google Scholar 

  • Mautino G, Oliver N, Chanez P, Bousquet J, Capony F (1997) Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics. Am J Respir Cell Mol Biol 17:583–591

    Article  CAS  PubMed  Google Scholar 

  • Moises S, Victor R, Sandra C, Lourdes S, Remedios R, Roberto B, Annie P (2000) TIMP-1,2,3and 4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment? Am J Physiol Lung Cell Mol Physiol 279:L-562–LL574

    Article  Google Scholar 

  • Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K (2009) A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 23:2810–2819

    Article  CAS  PubMed  Google Scholar 

  • Nenan S, Boichot E, Lagente V, Bertrand CP (2005) Macrophage elastase (MMP-12): a pro-inflammatory mediator? Mem Inst Oswaldo Cruz 100:167–172

    Article  CAS  PubMed  Google Scholar 

  • Ohno I, Ohtani H, Nitta Y, Suzuki J, Hoshi H, Honma M, Isoyama S, Tanno Y, Tamura G, Yamauchi K, Nagura H, Shirato K (1997) Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation. Am J Respir Cell Mol Biol 16:212–219

    Article  CAS  PubMed  Google Scholar 

  • Oshita Y, Koga T, Kamimura T, Matsuo K, Rikimaru T, Aizawa H (2003) Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma. Thorax 58:757–760

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pardo A, Cabrera S, Maldonado M, Selman M (2016) Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis. Respir Res 17:23

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pongnimitprasert N, El-Benna J, Foglietti MJ, Gougerot-Pocidalo MA, Bernard M, Braut-Boucher F (2008) Potential role of the “NADPH oxidases” (NOX/DUOX) family in cystic fibrosis. Ann Biol Clin (Paris) 66:621–629

    CAS  Google Scholar 

  • Porter S, Clark IM, Kevorkian L, Edwards DR (2005) The ADAMTS metalloproteinases. Biochem J 386(Pt 1):15–27

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prikk K, Maisi P, Pirila E, Reintam MA, Salo T, Sorsa T, Sepper R (2002) Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma. Lab Investig 82:1535–1545

    Article  CAS  PubMed  Google Scholar 

  • Raby BA, Klanderman B, Murphy A, Mazza S, Camargo CA Jr, Silverman EK, Weiss ST (2007) A common mitochondrial haplogroup is associated with elevated total serum IgE levels. J Allergy Clin Immunol. 120:351–358

    Article  CAS  PubMed  Google Scholar 

  • Raghu G, Striker L, Hudson LD, Striker GE (1985) Extracellular matrix in normal and fibrotic lungs. Am Rev Respir Dis 131:281–289

    CAS  PubMed  Google Scholar 

  • Raza SL, Nehring LC, Shapiro SD, Cornelius LA (2000) Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases. J Biol Chem 275:41243–41250

    Article  CAS  PubMed  Google Scholar 

  • Reddy PH (2011) Mitochondrial dysfunction and oxidative stress in asthma: implications for mitochondria-targeted antioxidant therapeutics. Pharmaceuticals (Basel) 4:429–456

    Article  CAS  Google Scholar 

  • Renauld JC (2001) New insights into the role of cytokines in asthma. J Clin Pathol 54:577–589

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Riese RJ, Wolf PR, Bromme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA (1996) Essential role for cathepsin S in MHC class II- associated invariant chain processing and peptide loading. Immunity 4(4):357–366

    Article  CAS  PubMed  Google Scholar 

  • Riese RJ, Mitchell RN, Villadangos J, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA (1998) Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest 101(11):2351–2363

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders M, Foidart JM, Noel A, Cataldo D (2008) Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie 90(2):369–379

    Article  CAS  PubMed  Google Scholar 

  • Seals DF, Courtneidge SA (2003) The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 17(1):7–30

    Article  CAS  PubMed  Google Scholar 

  • Selman M, King TE, Pardo A (2001) Idiopathic pulmonary fibrosis: prevailing evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134:136–151

    Article  CAS  PubMed  Google Scholar 

  • Sethi S, Murphy T (2008) Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 359:2355–2365

    Article  CAS  PubMed  Google Scholar 

  • Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A (2003) Neutrophil elastase contributes to cigarette smoke–induced emphysema in mice. Am J Pathol 163:2329–2335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30

    Article  PubMed  Google Scholar 

  • Sin DD, Pahlavan PS, Man SF (2008) Surfactant protein D: a lung specific biomarker in COPD? Ther Adv Respir Dis 2:65–74

    Article  PubMed  Google Scholar 

  • Snelgrove RJ (2011) Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme. Thorax 66:550–551

    Article  PubMed  Google Scholar 

  • Stocker W, Grams F, Baumann U, Reinemer P, Gomis-Ruth FX, McKay DB, Bode W (1995) The metzincins—topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc peptidases. Protein Sci 4(5):823–840

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tanaka H, Miyazaki N, Oashi K, Tanaka S, Ohmichi M, Abe S (2000) Sputum matrix metalloproteinase-9: tissue inhibitor of metalloproteinase-1 ratio in acute asthma. J Allergy Clin Immunol 105:900–905

    Article  CAS  PubMed  Google Scholar 

  • Thomas P, Khokha R, Shepherd FA, Feld R, Tsao MS (2000) Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer. J Pathol 190:150–156

    Article  CAS  PubMed  Google Scholar 

  • Togawa D, Koshino T, Saito T, Takagi T, Machida J (1999) Highly activated matrix metalloproteinase- 2 secreted from clones of metastatic lung nodules of nude mice injected with human fibrosarcoma HT1080. Cancer Lett 146:25–33

    Article  CAS  PubMed  Google Scholar 

  • Van Houwelingen AH, Weathington NM, Verweij V, Blalock JE, Nijkamp FP, Folkerts G (2008) Induction of lung emphysema is prevented by L-arginine-threonine-arginine. FASEB J 22:3403–3408

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vestbo J, Hurd SS, Rodriguez-Roisin R (2012) The 2011 revision of the global strategy for the diagnosis, management and prevention of COPD (GOLD)—why and what? Clin Respir J 6:208–214

    Article  PubMed  Google Scholar 

  • Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A et al (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187:347–365

    Article  CAS  PubMed  Google Scholar 

  • Vignola AM, Chanez P, Siena L, Chiappara G, Bonsignore G, Bousquet J (1998a) Airways remodelling in asthma. Pulm Pharmacol Ther 11:359–367

    Article  CAS  PubMed  Google Scholar 

  • Vignola AM, Riccobono L, Mirabella A, Profita M, Chanez P, Bellia V, Mautino G, D’Accardi P, Bousquet J, Bonsignore G (1998b) Sputum metalloproteinase-9 tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 158:1945–1950

    Article  CAS  PubMed  Google Scholar 

  • Vignola AM, Riccobono L, Mirabella A, Profita M, Chanez P, Bellia V, Mautino G, D’accardi P, Bousquet J, Bonsignore G (1999) Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 158:1945–1950

    Article  Google Scholar 

  • Vliagoftis H, Hollenberg MD, Befus AD, Moqbel R (2000) Airway epithelial cells release eosinophil survival promoting factors following stimulation of proteinase-activated receptor-2 (PAR-2). J Allergy Clin Immunol 105:S171

    Article  Google Scholar 

  • Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M et al (2014) DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol 50:912–922

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vuillemenot BR, Rodriguez JF, Hoyle GW (2004) Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing tumor necrosis factor-a. Am J Respir Cell Mol Biol 30:438–448

    Article  CAS  PubMed  Google Scholar 

  • Weathington NM, Van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, Folkerts G, Nijkamp FP, Blalock JE (2006) A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med 12:317–323

    Article  CAS  PubMed  Google Scholar 

  • Wenzel SE, Balzar S, Cundall M, Chu HW (2003) Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9. Association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 111:1345–1352

    Article  CAS  PubMed  Google Scholar 

  • Williams KE, Olsen DR (2009) Matrix metalloproteinase-1 cleavage site recognition and binding in full-length human type III collagen. Matrix Biol 28(6):373–379

    Article  CAS  PubMed  Google Scholar 

  • Woessner JF Jr (1994) The family of matrix metalloproteinases. Ann N Y Acad Sci 732:11–21

    Article  CAS  PubMed  Google Scholar 

  • Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I (2013) SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol 305:L615–L624

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoshida M, Whitsett JA (2006) Alveolar macrophages and emphysema in surfactant protein-D-deficient mice. Respirology 11(Suppl):S37–S40

    Article  PubMed  Google Scholar 

  • Yu Y, Sakai H, Misawa M, Chiba Y (2012) Matrix metalloproteinases-9 (MMPs-9) and -12 are upregulated in the airways of mice with chronic airway inflammation and remodeling. ISRN Pulmonology 2012:1–7

    Article  Google Scholar 

  • Zheng T, Zhu Z, Wang ZD, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA (2000) Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest 106:1081–1093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA (2002) Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A 99(9):6292–6297

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. Authors Nilanjana Deb and Sudipta Mallick have equally contributed to this chapter.

Authors and Affiliations

  1. Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India

    Nilanjana Deb, Sudipta Mallick, Anirban Manna & Snehasikta Swarnakar

  2. Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India

    Ashish Jaiswal & Ulaganathan Mabalirajan

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  1. Nilanjana Deb
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  2. Sudipta Mallick
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  3. Ashish Jaiswal
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  6. Snehasikta Swarnakar
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, USA

    Salil Kumar Das

  4. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

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Deb, N., Mallick, S., Jaiswal, A., Manna, A., Mabalirajan, U., Swarnakar, S. (2019). Role of MMPs and Oxidants in Lung Diseases. In: Chakraborti, S., Chakraborti, T., Das, S., Chattopadhyay, D. (eds) Oxidative Stress in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8413-4_8

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