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Protective Effects of Taurine on the Radiation Exposure Induced Cellular Damages in the Mouse Intestine

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Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

Abstract

There has been a growing interest in radiation effects as a result of the Fukushima nuclear power plant accident in 2011. Exposure to ionizing radiation causes oxidizing events to different organs such as the bone marrow, intestine, and kidney, which can result in radiation-induced injuries. Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid possessing several important physiological functions, including membrane stabilization, anti-oxidative activity, anti-inflammatory effects and modulation of intracellular calcium levels. Taurine appears to be an attractive candidate for use as a radioprotector and as a radiation mitigator, but its protection mechanism against radiation-induced cell damage is still unclear until now. In this review we describe some of the mechanisms explaining the radioprotective/mitigating effects of taurine on radiation-induced cellular damage and our recent findings on this subject.

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Abbreviations

Tau:

Taurine

TauT:

Taurine transporter

ROS:

Reactive oxygen species

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Acknowledgements

We thank Yui Naganuma, Yusuke Hasegawa and Riki Miyabayashi for the handling of the animals and for assistance in the drug administration part of this work. This work was supported by JSPS KAKENHI Grant Number JP 17K15809 and in part of JP 17H04654.

Author information

Authors and Affiliations

  1. Division of Health Science, Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan

    Takenori Yamashita & Ning Ma

  2. Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Japan

    Takenori Yamashita & Tamami Isogai

  3. Department of Rehabilitation, Suzuka Kaisei Hospital, Suzuka, Japan

    Toshihiro Kato

  4. Faculty of Health Science, Junshin Gakuen University, Fukuoka, Japan

    Yeunhwa Gu

Authors
  1. Takenori Yamashita
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  2. Toshihiro Kato
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  3. Tamami Isogai
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  4. Yeunhwa Gu
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  5. Ning Ma
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Corresponding author

Correspondence to Ning Ma .

Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

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Yamashita, T., Kato, T., Isogai, T., Gu, Y., Ma, N. (2019). Protective Effects of Taurine on the Radiation Exposure Induced Cellular Damages in the Mouse Intestine. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_41

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