Biomedical Application of Nanoparticles for Channel Protein Modulation to Control Neural Disorder with Special Reference to Seizure

Abstract

Channel proteins are the regulators of entry and exit of different molecules and ion to and fro from the cells. Regulation of entry and exit of molecules through different channel proteins can control different disorders. Therapeutic agents are used to target the channel protein to regulate ionic entry. Engineered channel proteins are developed to modify the channel protein movement. Epilepsy, which is marked by repeated seizures, is one of the serious neural disorder prevailing worldwide. Epileptic disorder is an electrophysiological alteration in the neuronal level and these electrophysiological changes are regulated by inward and outward movement of sodium, calcium, potassium, chloride ions, etc. Ions move through different channel proteins, and their movements are regulated by different channel proteins. These channel proteins are charge dependent and can be modulated by charged molecules. Nanoparticles are charged molecules and can be used to modulate channel proteins. Besides, nanoparticles have more exceptional properties than its raw materials which are helpful in the drug delivery approach. In the present article, it is targeted to focus and highlight the structural and functional approach of channel proteins and application of nanoparticles to control channel protein regulation which can help control different neural disorders including seizure.