Skip to main content
SpringerLink
Log in

Stem Cells: A New Hope for Hearing Loss Therapy

  • Chapter
  • First Online:
Hearing Loss: Mechanisms, Prevention and Cure

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1130))

Abstract

Permanent hearing loss was considered which cannot be cured since cochlear hair cells and primary afferent neurons cannot be regenerated. In recent years, due to the in-depth study of stem cell and its therapeutic potential, regenerating auditory sensory cells is made possible. By using two strategies of endogenous stem cell activation and exogenous stem cell transplantation, researchers hope to find methods to restore hearing function. However, there are complex factors that need to be considered in the in vivo application of stem cell therapy, such as stem cell-type choice, signaling pathway regulations, transplantation approaches, internal environment of the cochlea, and external stimulation. After years of investigations, some theoretic progress has been made in the treatment of hearing loss using stem cells, but there are also many problems which limited its application that need to be solved. Understanding the future perspective of stem cell therapy in hearing loss, solving the encountered problems, and promoting its development are the common goals of audiological researchers. In this review, we present critical experimental findings of stem cell therapy on treatment of hearing loss and intend to bring hope to researchers and patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Jacob S, Johansson C, Fridberger A (2013) Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification. Pflugers Arch 465(6):907–917

    Article  CAS  PubMed  Google Scholar 

  2. Geleoc GS, Holt JR (2014) Sound strategies for hearing restoration. Science 344(6184):1241062

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Starr A, Rance G (2015) Auditory neuropathy. Handb Clin Neurol 129:495–508

    Article  PubMed  Google Scholar 

  4. Tucci DL, Rubel EW (1990) Physiologic status of regenerated hair cells in the avian inner ear following aminoglycoside ototoxicity. Otolaryngol Head Neck Surg 103(3):443–450

    Article  CAS  PubMed  Google Scholar 

  5. Cotanche DA, Dopyera CE (1990) Hair cell and supporting cell response to acoustic trauma in the chick cochlea. Hear Res 46(1–2):29–40

    Article  CAS  PubMed  Google Scholar 

  6. Li H, Liu H, Heller S (2003) Pluripotent stem cells from the adult mouse inner ear. Nat Med 9(10):1293–1299

    Article  CAS  PubMed  Google Scholar 

  7. Oshima K, Grimm CM, Corrales CE et al (2007) Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol 8(1):18–31

    Article  PubMed  Google Scholar 

  8. Martinez-Monedero R, Oshima K, Heller S, Edge AS (2007) The potential role of endogenous stem cells in regeneration of the inner ear. Hear Res 227(1–2):48–52

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chen J, Streit A (2013) Induction of the inner ear: stepwise specification of otic fate from multipotent progenitors. Hear Res 297:3–12

    Article  PubMed  Google Scholar 

  10. Bermingham-McDonogh O, Reh TA (2011) Regulated reprogramming in the regeneration of sensory receptor cells. Neuron 71(3):389–405

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mulvaney J, Dabdoub A (2012) Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency. J Assoc Res Otolaryngol 13(3):281–293

    Article  PubMed  PubMed Central  Google Scholar 

  12. Su YX, Hou CC, Yang WX (2015) Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5. Gene 558(1):6–24

    Article  CAS  PubMed  Google Scholar 

  13. Zheng JL, Shou J, Guillemot F, Kageyama R, Gao WQ (2000) Hes1 is a negative regulator of inner ear hair cell differentiation. Development 127(21):4551–4560

    Article  CAS  PubMed  Google Scholar 

  14. Zine A, Aubert A, Qiu J et al (2001) Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci 21(13):4712–4720

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Dabdoub A, Puligilla C, Jones JM et al (2008) Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A 105(47):18396–18401

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Lanford PJ, Lan Y, Jiang R et al (1999) Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat Genet 21(3):289–292

    Article  CAS  PubMed  Google Scholar 

  17. Van Camp JK, Beckers S, Zegers D, Van Hul W (2014) Wnt signaling and the control of human stem cell fate. Stem Cell Rev 10(2):207–229

    Article  CAS  Google Scholar 

  18. Shi F, Hu L, Jacques BE, Mulvaney JF, Dabdoub A, Edge AS (2014) beta-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci 34(19):6470–6479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Li H, Kloosterman W, Fekete DM (2010) MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci 30(9):3254–3263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Hei R, Chen J, Qiao L et al (2011) Dynamic changes in microRNA expression during differentiation of rat cochlear progenitor cells in vitro. Int J Pediatr Otorhinolaryngol 75(8):1010–1014

    Article  PubMed  Google Scholar 

  21. Wang XR, Zhang XM, Du J, Jiang H (2012) MicroRNA-182 regulates otocyst-derived cell differentiation and targets T-box 1 gene. Hear Res 286(1–2):55–63

    Article  CAS  PubMed  Google Scholar 

  22. Barker N, van Es JH, Kuipers J et al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165):1003–1007

    Article  CAS  PubMed  Google Scholar 

  23. Chai R, Xia A, Wang T et al (2011) Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol 12(4):455–469

    Article  PubMed  PubMed Central  Google Scholar 

  24. Chai R, Kuo B, Wang T et al (2012) Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A 109(21):8167–8172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS (2014) Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Rep 2(3):311–322

    Article  CAS  Google Scholar 

  26. Zak M, Klis SF, Grolman W (2015) The Wnt and notch signalling pathways in the developing cochlea: formation of hair cells and induction of regenerative potential. Int J Dev Neurosci 47(Pt B):247–258

    Article  CAS  PubMed  Google Scholar 

  27. Ni W, Lin C, Guo L et al (2016) Extensive supporting cell proliferation and mitotic hair cell generation by in vivo genetic reprogramming in the neonatal mouse cochlea. J Neurosci 36(33):8734–8745

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Ni W, Zeng S, Li W et al (2016) Wnt activation followed by notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. Oncotarget 7(41):66754–66768

    Article  PubMed  PubMed Central  Google Scholar 

  29. Hakuba N, Koga K, Gyo K, Usami SI, Tanaka K (2000) Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci 20(23):8750–8753

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Kujawa SG, Liberman MC (2009) Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J Neurosci 29(45):14077–14085

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Martinez-Monedero R, Yi E, Oshima K, Glowatzki E, Edge AS (2008) Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol 68(5):669–684

    Article  CAS  PubMed  Google Scholar 

  32. Rask-Andersen H, Bostrom M, Gerdin B et al (2005) Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and Guinea pig spiral ganglion. Hear Res 203(1–2):180–191

    Article  CAS  PubMed  Google Scholar 

  33. Wang Q, Green SH (2011) Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro. J Neurosci 31(21):7938–7949

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Lang H, Li M, Kilpatrick LA et al (2011) Sox2 up-regulation and glial cell proliferation following degeneration of spiral ganglion neurons in the adult mouse inner ear. J Assoc Res Otolaryngol 12(2):151–171

    Article  PubMed  Google Scholar 

  35. Lunn JS, Sakowski SA, Hur J, Feldman EL (2011) Stem cell technology for neurodegenerative diseases. Ann Neurol 70(3):353–361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Drago D, Cossetti C, Iraci N et al (2013) The stem cell secretome and its role in brain repair. Biochimie 95(12):2271–2285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Murrell W, Palmero E, Bianco J et al (2013) Expansion of multipotent stem cells from the adult human brain. PLoS One 8(8):e71334

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hildebrand MS, Dahl HH, Hardman J, Coleman B, Shepherd RK, de Silva MG (2005) Survival of partially differentiated mouse embryonic stem cells in the scala media of the Guinea pig cochlea. J Assoc Res Otolaryngol 6(4):341–354

    Article  PubMed  PubMed Central  Google Scholar 

  39. Sekiya T, Kojima K, Matsumoto M, Kim TS, Tamura T, Ito J (2006) Cell transplantation to the auditory nerve and cochlear duct. Exp Neurol 198(1):12–24

    Article  PubMed  Google Scholar 

  40. Reyes JH, O’Shea KS, Wys NL et al (2008) Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. J Neurosci 28(48):12622–12631

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Coleman B, Hardman J, Coco A et al (2006) Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell Transplant 15(5):369–380

    Article  CAS  PubMed  Google Scholar 

  42. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS (2006) Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol 66(13):1489–1500

    Article  PubMed  PubMed Central  Google Scholar 

  43. Bas E, Van De Water TR, Lumbreras V et al (2014) Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion. Stem Cells Dev 23(5):502–514

    Article  CAS  PubMed  Google Scholar 

  44. Boddy SL, Chen W, Romero-Guevara R, Kottam L, Bellantuono I, Rivolta MN (2012) Inner ear progenitor cells can be generated in vitro from human bone marrow mesenchymal stem cells. Regen Med 7(6):757–767

    Article  CAS  PubMed  Google Scholar 

  45. Duran Alonso MB, Feijoo-Redondo A, Conde de Felipe M et al (2012) Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells. Regen Med 7(6):769–783

    Article  CAS  PubMed  Google Scholar 

  46. Cho YB, Cho HH, Jang S, Jeong HS, Park JS (2011) Transplantation of neural differentiated human mesenchymal stem cells into the cochlea of an auditory-neuropathy Guinea pig model. J Korean Med Sci 26(4):492–498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Lee JH, Kang WK, Seo JH et al (2012) Neural differentiation of bone marrow-derived mesenchymal stem cells: applicability for inner ear therapy. Korean J Audiol 16(2):47–53

    Article  PubMed  PubMed Central  Google Scholar 

  48. Peng T, Zhu G, Dong Y et al (2015) BMP4: a possible key factor in differentiation of auditory neuron-like cells from bone-derived mesenchymal stromal cells. Clin Lab 61(9):1171–1178

    CAS  PubMed  Google Scholar 

  49. Parker MA, Corliss DA, Gray B et al (2007) Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hear Res 232(1–2):29–43

    Article  PubMed  PubMed Central  Google Scholar 

  50. Hu Z, Ulfendahl M, Prieskorn DM, Olivius P, Miller JM (2009) Functional evaluation of a cell replacement therapy in the inner ear. Otol Neurotol 30(4):551–558

    Article  PubMed  PubMed Central  Google Scholar 

  51. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663–676

    Article  CAS  PubMed  Google Scholar 

  52. Nishimura K, Nakagawa T, Ono K et al (2009) Transplantation of mouse induced pluripotent stem cells into the cochlea. Neuroreport 20(14):1250–1254

    Article  PubMed  Google Scholar 

  53. Chen J, Guan L, Zhu H, Xiong S, Zeng L, Jiang H (2017) Transplantation of mouse-induced pluripotent stem cells into the cochlea for the treatment of sensorineural hearing loss. Acta Otolaryngol 137(11):1136–1142

    Article  CAS  PubMed  Google Scholar 

  54. Matsuoka AJ, Kondo T, Miyamoto RT, Hashino E (2006) In vivo and in vitro characterization of bone marrow-derived stem cells in the cochlea. Laryngoscope 116(8):1363–1367

    Article  PubMed  Google Scholar 

  55. Hu Z, Wei D, Johansson CB et al (2005) Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Exp Cell Res 302(1):40–47

    Article  CAS  PubMed  Google Scholar 

  56. Sekiya T, Holley MC, Kojima K, Matsumoto M, Helyer R, Ito J (2007) Transplantation of conditionally immortal auditory neuroblasts to the auditory nerve. Eur J Neurosci 25(8):2307–2318

    Article  PubMed  Google Scholar 

  57. Wang M, Qiu J, Mi W, Wang F, Qu J (2011) In vitro effect of altering potassium concentration in artificial endolymph on apoptosis and ultrastructure features of olfactory bulb neural precursor cells. Neurosci Lett 487(3):383–388

    Article  CAS  PubMed  Google Scholar 

  58. Iguchi F, Nakagawa T, Tateya I, et al (2004) Surgical techniques for cell transplantation into the mouse cochlea. Acta Otolaryngol Suppl (551):43–47

    Google Scholar 

  59. Izumikawa M, Minoda R, Kawamoto K et al (2005) Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 11(3):271–276

    Article  CAS  PubMed  Google Scholar 

  60. Hu Z, Ulfendahl M, Olivius NP (2004) Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve. Brain Res 1026(1):68–73

    Article  CAS  PubMed  Google Scholar 

  61. Palmgren B, Jin Z, Jiao Y, Kostyszyn B, Olivius P (2011) Horseradish peroxidase dye tracing and embryonic statoacoustic ganglion cell transplantation in the rat auditory nerve trunk. Brain Res 1377:41–49

    Article  CAS  PubMed  Google Scholar 

  62. Zhang PZ, He Y, Jiang XW et al (2013) Stem cell transplantation via the cochlear lateral wall for replacement of degenerated spiral ganglion neurons. Hear Res 298:1–9

    Article  CAS  PubMed  Google Scholar 

  63. Lang H, Schulte BA, Goddard JC et al (2008) Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury. J Assoc Res Otolaryngol 9(2):225–240

    Article  PubMed  PubMed Central  Google Scholar 

  64. Matsuoka AJ, Kondo T, Miyamoto RT, Hashino E (2007) Enhanced survival of bone-marrow-derived pluripotent stem cells in an animal model of auditory neuropathy. Laryngoscope 117(9):1629–1635

    Article  PubMed  Google Scholar 

  65. Yu SP, Yeh C, Strasser U, Tian M, Choi DW (1999) NMDA receptor-mediated K+ efflux and neuronal apoptosis. Science 284(5412):336–339

    Article  CAS  PubMed  Google Scholar 

  66. Schulz JB, Weller M, Klockgether T (1996) Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci 16(15):4696–4706

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Wang SP, Wang JA, Luo RH, Cui WY, Wang H (2008) Potassium channel currents in rat mesenchymal stem cells and their possible roles in cell proliferation. Clin Exp Pharmacol Physiol 35(9):1077–1084

    Article  CAS  PubMed  Google Scholar 

  68. Yu SP, Canzoniero LM, Choi DW (2001) Ion homeostasis and apoptosis. Curr Opin Cell Biol 13(4):405–411

    Article  CAS  PubMed  Google Scholar 

  69. Mothe AJ, Kulbatski I, Parr A, Mohareb M, Tator CH (2008) Adult spinal cord stem/progenitor cells transplanted as neurospheres preferentially differentiate into oligodendrocytes in the adult rat spinal cord. Cell Transplant 17(7):735–751

    Article  PubMed  Google Scholar 

  70. Altschuler RA, O’Shea KS, Miller JM (2008) Stem cell transplantation for auditory nerve replacement. Hear Res 242(1–2):110–116

    Article  PubMed  PubMed Central  Google Scholar 

  71. He Y, Zhang PZ, Sun D et al (2014) Wnt1 from cochlear schwann cells enhances neuronal differentiation of transplanted neural stem cells in a rat spiral ganglion neuron degeneration model. Cell Transplant 23(6):747–760

    Article  PubMed  Google Scholar 

  72. Imitola J, Raddassi K, Park KI et al (2004) Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A 101(52):18117–18122

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Bagri A, Gurney T, He X et al (2002) The chemokine SDF1 regulates migration of dentate granule cells. Development 129(18):4249–4260

    Article  CAS  PubMed  Google Scholar 

  74. Klein RS, Rubin JB, Gibson HD et al (2001) SDF-1 alpha induces chemotaxis and enhances sonic hedgehog-induced proliferation of cerebellar granule cells. Development 128(11):1971–1981

    Article  CAS  PubMed  Google Scholar 

  75. Reiss K, Mentlein R, Sievers J, Hartmann D (2002) Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer. Neuroscience 115(1):295–305

    Article  CAS  PubMed  Google Scholar 

  76. Belmadani A, Tran PB, Ren D, Assimacopoulos S, Grove EA, Miller RJ (2005) The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci 25(16):3995–4003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Zhang PZ, He Y, Jiang XW et al (2013) Up-regulation of stromal cell-derived factor-1 enhances migration of transplanted neural stem cells to injury region following degeneration of spiral ganglion neurons in the adult rat inner ear. Neurosci Lett 534:101–106

    Article  CAS  PubMed  Google Scholar 

  78. Zhang LI, Bao S, Merzenich MM (2001) Persistent and specific influences of early acoustic environments on primary auditory cortex. Nat Neurosci 4(11):1123–1130

    Article  CAS  PubMed  Google Scholar 

  79. Percaccio CR, Pruette AL, Mistry ST, Chen YH, Kilgard MP (2007) Sensory experience determines enrichment-induced plasticity in rat auditory cortex. Brain Res 1174:76–91

    Article  CAS  PubMed  Google Scholar 

  80. Zhou X, Nagarajan N, Mossop BJ, Merzenich MM (2008) Influences of un-modulated acoustic inputs on functional maturation and critical-period plasticity of the primary auditory cortex. Neuroscience 154(1):390–396

    Article  CAS  PubMed  Google Scholar 

  81. Chen Y, Qiu J, Chen F, Liu S (2007) Migration of neural precursor cells derived from olfactory bulb in cochlear nucleus exposed to an augmented acoustic environment. Hear Res 228(1–2):3–10

    Article  PubMed  Google Scholar 

  82. Nuccitelli R (2003) A role for endogenous electric fields in wound healing. Curr Top Dev Biol 58:1–26

    Article  PubMed  Google Scholar 

  83. Nuccitelli R (2003) Endogenous electric fields in embryos during development, regeneration and wound healing. Radiat Prot Dosim 106(4):375–383

    Article  CAS  Google Scholar 

  84. Stump RF, Robinson KR (1983) Xenopus neural crest cell migration in an applied electrical field. J Cell Biol 97(4):1226–1233

    Article  CAS  PubMed  Google Scholar 

  85. Babona-Pilipos R, Droujinine IA, Popovic MR, Morshead CM (2011) Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields. PLoS One 6(8):e23808

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Hinkle L, McCaig CD, Robinson KR (1981) The direction of growth of differentiating neurones and myoblasts from frog embryos in an applied electric field. J Physiol 314:121–135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Pomeranz B, Mullen M, Markus H (1984) Effect of applied electrical fields on sprouting of intact saphenous nerve in adult rat. Brain Res 303(2):331–336

    Article  CAS  PubMed  Google Scholar 

  88. Borgens RB, Roederer E, Cohen MJ (1981) Enhanced spinal cord regeneration in lamprey by applied electric fields. Science 213(4508):611–617

    Article  CAS  PubMed  Google Scholar 

  89. Zhu W, Ye T, Lee SJ et al (2017) Enhanced neural stem cell functions in conductive annealed carbon nanofibrous scaffolds with electrical stimulation. Nanomedicine 14:2485–2494

    Article  PubMed  CAS  Google Scholar 

  90. Park SY, Park J, Sim SH et al (2011) Enhanced differentiation of human neural stem cells into neurons on graphene. Adv Mater 23(36):H263–H267

    Article  CAS  PubMed  Google Scholar 

  91. Shi F, Corrales CE, Liberman MC, Edge AS (2007) BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci 26(11):3016–3023

    Article  PubMed  Google Scholar 

  92. Thonabulsombat C, Johansson S, Spenger C, Ulfendahl M, Olivius P (2007) Implanted embryonic sensory neurons project axons toward adult auditory brainstem neurons in roller drum and Stoppini co-cultures. Brain Res 1170:48–58

    Article  CAS  PubMed  Google Scholar 

  93. Gao X, Tao Y, Lamas V et al (2018) Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature 553(7687):217–221

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an, Shaanxi, People’s Republic of China

    Yang Qiu & Jianhua Qiu

  2. Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China

    Yang Qiu

  3. ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, People’s Republic of China

    Yang Qiu

Authors
  1. Yang Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jianhua Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jianhua Qiu .

Editor information

Editors and Affiliations

  1. Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China

    Huawei Li

  2. MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China

    Renjie Chai

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Qiu, Y., Qiu, J. (2019). Stem Cells: A New Hope for Hearing Loss Therapy. In: Li, H., Chai, R. (eds) Hearing Loss: Mechanisms, Prevention and Cure. Advances in Experimental Medicine and Biology, vol 1130. Springer, Singapore. https://doi.org/10.1007/978-981-13-6123-4_10

Download citation

Publish with us

Policies and ethics

Search

Navigation