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Organoid Models of Development and Disease Towards Therapy

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Medical Applications of iPS Cells

Part of the book series: Current Human Cell Research and Applications ((CHCRA))

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Abstract

Historical developmental biology experiments demonstrated the remarkable capacity of reaggregated vertebrate cells for self-organization, now exploited to rebuild human tissues, reminiscent of native organs, from somatic or pluripotent stem cells, namely, an organoid. Organoid technology is thus rapidly evolving and becoming an independent research field due to its potential for modelling human development and disease. Coupled with patient-derived stem cells, diseased organoid recapitulates a pathological state in a dish, promoting personalized medicine and drug development. Ultimately, organoid transplantation paves a way for organ replacement strategies against end-stage diseases. This article summarizes the evolutionary organoid technology backed by developmental biology and outlines its phenomenal potential for future therapeutic applications.

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Authors and Affiliations

  1. T-CiRA, Regenerative Medicine Unit, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan

    Yasunori Nio & Takanori Takebe

  2. Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

    Takanori Takebe

  3. Organogenesis and Neogenesis Unit, Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan

    Takanori Takebe

  4. Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Takanori Takebe

  5. Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Takanori Takebe

  6. Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan

    Takanori Takebe

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  2. Takanori Takebe
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Correspondence to Takanori Takebe .

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  1. CiRA, Kyoto University, Kyoto, Japan

    Haruhisa Inoue

  2. Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba-shi Ibaraki, Japan

    Yukio Nakamura

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Nio, Y., Takebe, T. (2019). Organoid Models of Development and Disease Towards Therapy. In: Inoue, H., Nakamura, Y. (eds) Medical Applications of iPS Cells . Current Human Cell Research and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-13-3672-0_9

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  • DOI: https://doi.org/10.1007/978-981-13-3672-0_9

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