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Endometriosis and Endometriosis-Associated Tumors

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Gynecologic and Obstetric Pathology, Volume 2

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Abstract

Endometriosis is a chronic gynecologic disorder that affects ~10% of adolescent girls and premenopausal women. The condition, classically defined as the presence of endometrial glands and stroma outside of the uterine cavity, is multifactorial and highly recurrent, and causes considerable morbidities that can significantly diminish the quality of life of affected women. The disease is linked to immune dysfunctions, infertility, and increased risk for ovarian and other cancers. The histological diagnosis of endometriosis, while typically uncomplicated, may be compromised by the heterogeneity of the endometriotic foci which can manifest a spectrum of lesions with distinct and atypical features of stromal and glandular components. Moreover, signs and symptoms of endometriosis remain nonspecific and there is a current lack of predictive noninvasive markers. This chapter aims to provide current understanding of the etiology, pathogenesis, and clinicopathologic features of endometriosis and to highlight the remaining challenges clinicians and pathologists face in the diagnosis, management of symptoms, and provision of care in women with this condition.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Rosalia C. M. Simmen

  2. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Charles Matthew Quick

  3. Department of Obstetrics and Gynecology, University of Michigan Health Systems, Ann Arbor, MI, USA

    Angela S. Kelley

  4. Departments of Pathology, Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Wenxin Zheng

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  1. Rosalia C. M. Simmen
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  2. Charles Matthew Quick
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  3. Angela S. Kelley
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  4. Wenxin Zheng
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Correspondence to Rosalia C. M. Simmen .

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Editors and Affiliations

  1. Department of Pathology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Wenxin Zheng

  2. Department of Pathology, University of California San Diego, San Diego, CA, USA

    Oluwole Fadare

  3. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Charles Matthew Quick

  4. Department of Pathology, Peking University People’s Hospital, Beijing, China

    Danhua Shen

  5. Department of Obstetrics and Gynecology, Tianjin Gynecologic and Obstetrics Central Hospital, Tianjin, China

    Donghui Guo

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Simmen, R.C.M., Quick, C.M., Kelley, A.S., Zheng, W. (2019). Endometriosis and Endometriosis-Associated Tumors. In: Zheng, W., Fadare, O., Quick, C., Shen, D., Guo, D. (eds) Gynecologic and Obstetric Pathology, Volume 2. Springer, Singapore. https://doi.org/10.1007/978-981-13-3019-3_12

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