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Natural Therapeutics for Alzheimer’s Disease

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Functional Food and Human Health

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease which is serious, persistent and progressive and is linked with deterioration of memory and cognition. Commonly, Alzheimer’s is the reason to cause dementia in aged people. The pathogenesis of this disease is linked with the buildup of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) in brain tissues, and also the tau protein gets hyper-phosphorylated in neurons. The generation of reactive oxygen species (ROS) as a result of oxidative stress is regarded as the main cause of AD. The present treatment offers only symptomatic relief which turns down the rate of cognitive destruction related with AD. Inhibition of the enzyme acetylcholinesterase (AChE) is believed as one of the key therapeutic approach contributing only symptomatic relief and modest disease modifying result. None of the drugs currently available could delay or halt the progression of AD. Several compounds showed positive results in preclinical studies but failed in clinical trials as they had limited targeting because of their inability to cross blood-brain barrier (BBB). Several problems exist in the development of new therapeutics. Medicinal plants have been reported for promising anti-AD action in many preclinical and clinical trials. Natural compounds provide various structural characteristics and biological activities and therefore are an attractive source for developing compounds against AD. Advance in extraction and separation method leads to the generation of natural products as potential therapeutics. Various medicinal plants also in their basic structure or as secluded compounds have demonstrated to lessen the pathological characteristics related with AD. In this chapter an effort has been made to focus on natural substances having role in anti-Alzheimer’s therapy with their source, mechanism of action and limitations.

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Authors and Affiliations

  1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

    Shweta Dang, Deeksha Mehtani, Atinderpal Kaur & Reema Gabrani

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  1. Shweta Dang
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  2. Deeksha Mehtani
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Correspondence to Shweta Dang .

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  1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

    Vibha Rani

  2. School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Umesh C. S. Yadav

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Dang, S., Mehtani, D., Kaur, A., Gabrani, R. (2018). Natural Therapeutics for Alzheimer’s Disease. In: Rani, V., Yadav, U. (eds) Functional Food and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-13-1123-9_11

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