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Novel Biomarkers in Deep Vein Thrombosis

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Venous Disorders

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Abstract

Venous thromboembolic disease (VTE) remains a significant source of morbidity and mortality. As non-specific subjective complaints and a paucity of objective clinical examination findings complicate the diagnosis of both deep venous thrombosis (DVT) and pulmonary embolism (PE), diagnostic modalities remain essential. Symptoms suggestive of deep vein thrombosis are extremely common in practice but unfortunately non-specific. The modified Wells score remains the most supported clinical decision rule for risk stratifying these concerns. Compression ultrasound remains the gold standard for diagnosis of DVT. Reliable imaging is not always available, so making a serologic diagnosis, or biomarker, is highly desirable. While D-dimer, a highly sensitive biomarker, is useful for excluding acute VTE, it lacks the specificity necessary for diagnostic confirmation. As such, ongoing research efforts target and support the utility of alternative plasma biomarkers to aid in the diagnosis of VTE including selectins, microparticles, IL-10, and other inflammatory markers. These molecular markers may also predict recurrence risk, guide length and modality of treatment, and predict which thrombi will resolve spontaneously or recanalize, thus potentially identifying patients who would benefit from more aggressive therapies than standard anticoagulation [1].

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Authors and Affiliations

  1. Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    Ajay K. Khanna

  2. Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    Manbendra Vaidya & Soumya Khanna

Authors
  1. Ajay K. Khanna
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  2. Manbendra Vaidya
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  3. Soumya Khanna
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Editors and Affiliations

  1. Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    Ajay K. Khanna

  2. Vascular and Endovascular Surgery, Fortis Hospital, Mohali, India

    Ravul Jindal

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Khanna, A.K., Vaidya, M., Khanna, S. (2018). Novel Biomarkers in Deep Vein Thrombosis. In: Khanna, A., Jindal, R. (eds) Venous Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-1108-6_12

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  • DOI: https://doi.org/10.1007/978-981-13-1108-6_12

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-1107-9

  • Online ISBN: 978-981-13-1108-6

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