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Genetics and Susceptibility of Retinal Eye Diseases in India

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Advances in Vision Research, Volume II

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

As per the World Health Organization, genetic eye disorders are one of the top ten major causes of global ocular health burden. AMD and DR take major share of the adult eye diseases component that particularly affects the neurovascular retina. More than 100 genes are known to cause Mendelian types of retinal degenerations including syndromic and non-syndromic RP, and it is presumed that this constitutes only 60% of all the genes known so far, and the remaining are yet to be identified. The burden of genetic disorders in India is significant, and very many significant genes like RPE65 have been identified with consanguineous autosomal recessive pedigrees obtained from this region.

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Authors and Affiliations

  1. Aditya Jyot Foundation for Twinkling Little Eyes, Mumbai, India

    Sunita Mohan, Sundaram Natarajan & Govindasamy Kumaramanickavel

  2. Center for Medical Genetics, Chennai, India

    Uthra Satagopan

  3. MedGenome, Bangalore, India

    Soumittra Nagasamy

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  1. Sunita Mohan
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  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA

    Gyan Prakash

  2. National Institute of Sensory Organs Tokyo Medical Center, National Hospital Organization, Tokyo, Japan

    Takeshi Iwata

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Mohan, S., Satagopan, U., Nagasamy, S., Natarajan, S., Kumaramanickavel, G. (2019). Genetics and Susceptibility of Retinal Eye Diseases in India. In: Prakash, G., Iwata, T. (eds) Advances in Vision Research, Volume II. Essentials in Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-13-0884-0_15

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