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Signaling Pathways of Anticancer Plants: Action and Reaction

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Anticancer Plants: Clinical Trials and Nanotechnology

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Abstract

Insights into the alterations of the mammalian genome in neoplastic diseases and the mechanism of action of the therapeutic anticancer drugs are one of the extremely important, diverse, and challenging areas of study currently. By the virtue of lingering toxicity of the reputable chemical drugs, plant-derived anticancer substances, viz., vinblastine, vincristine, Taxol, topotecan, camptothecin, and podophyllotoxin derivatives, are highly safe and efficient in the treatment and management of this monstrous disease. Among the list of accessible targets of the therapeutic drugs, DNA replication and mitosis, hormonal regulation of cell growth, aberrant signaling pathways, cell surface receptors, and second messengers are noteworthy. Nowadays, newer therapeutic approaches are being followed, and an increased understanding into the mechanism of action of the therapeutic anticancer agents is evolving due to continuous and relentless efforts of the researchers. The aim of the present chapter is to highlight the application of medicinal plants and their secondary metabolites as anticancer substances and also focus on the signaling aspects of potential anticancer compounds to find out their mechanisms of action against cancer cells.

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Authors and Affiliations

  1. Department of Botany, Aligarh Muslim University, Aligarh, India

    Bilal Ahmad, Mohd Irfan Naikoo, Hassan Jaleel, Asfia Shabbir, Yawar Sadiq & M. Masroor Akhtar Khan

  2. Department of Botany, Mohammad Ali Jauhar University, Rampur, India

    Farha Rehman

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  1. Bilal Ahmad
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  2. Mohd Irfan Naikoo
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  3. Hassan Jaleel
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  4. Asfia Shabbir
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  6. Yawar Sadiq
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  7. M. Masroor Akhtar Khan
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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Ahmad, B. et al. (2017). Signaling Pathways of Anticancer Plants: Action and Reaction. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Clinical Trials and Nanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8216-0_11

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