Abstract
As an alkaloid derived from Camptotheca acuminata, camptothecin exerted its anticancer activity by specifically targeted topoisomerase I. The intolerable toxicity and poor solubility and stability in vivo of camptothecin limited its clinical application, but the sequential approval of camptothecin derivatives has provided patients with a new selection for the treatment of cancer. Camptothecin is often used in combination with other drugs in clinical application. As one of the most important anticancer drugs derived from plants, camptothecin played an important role in the treatment of cancer with its unique anticancer mechanism and therapeutic effect.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Kang, D., Liu, AL., Wang, JH., Du, GH. (2018). Camptothecin. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_81
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DOI: https://doi.org/10.1007/978-981-10-8022-7_81
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