Abstract
Aristolochic acid first appeared in Chinese medicine in the fifth century AD, while it was used to treat kidney and urinary diseases, as well as gout, snakebites, and a variety of other ailments. Balkan endemic nephropathy (BEN) was later found to be also the result of aristolochic acid (AA) consumption. Aristolochia species are nephrotoxic and carcinogenic, and FDA has issued warnings regarding consumption of AA-containing supplements.
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References
Kuo PC, Li YC, Wu TS. Chemical constituents and pharmacology of the Aristolochia (madou ling) species. J Tradit Complement Med. 2012;2(4):249–66.
Vanherweghem JL, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993;341(8842):387–91.
Balachandran P, et al. Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int. 2005;67(5):1797–805.
Nedelko T, et al. TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours. Int J Cancer. 2009;124(4):987–90.
Chen CH, et al. Aristolochic acid-associated urothelial cancer in Taiwan. Proc Natl Acad Sci U S A. 2012;109(21):8241–6.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Yan, R., Li, L., Du, GH. (2018). Aristolochic Acid. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_108
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DOI: https://doi.org/10.1007/978-981-10-8022-7_108
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