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Targeting Transcriptional Factors in Gastrointestinal Cancers and Future Prospective

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Role of Transcription Factors in Gastrointestinal Malignancies

Abstract

Transcription factors (TFs) are deregulated in the majority of human cancers and play a major role in tumor progression and metastasis. Targeting TFs could prove to be highly effective in the treatment of gastrointestinal (GI) malignancies, as highlighted by the clinical efficiency of target molecules aiming at the nuclear hormone receptors. In this chapter, we summarize the role of different TFs discussed in the previous chapters with a focus on the emerging chemical as well as phytochemical approaches to control their functions. The outstanding diversity and efficacy of TFs as the driving force of cell transformation demands a continued search of TFs as novel and therapeutic agents for anti-GI treatments.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

  2. Department of Zoology and Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha, India

    Ganji Purnachandra Nagaraju

  3. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

  4. Department of Zoology and Department of Biotechnology, Berhampur University, Berhampur, Odisha, India

    Subasini Pattnaik

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  1. Ganji Purnachandra Nagaraju
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  2. Pallaval Veera Bramhachari
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  3. Subasini Pattnaik
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Correspondence to Ganji Purnachandra Nagaraju or Subasini Pattnaik .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Nagaraju, G.P., Bramhachari, P.V., Pattnaik, S. (2017). Targeting Transcriptional Factors in Gastrointestinal Cancers and Future Prospective. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_38

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