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Expression of DJ-1 in Neurodegenerative Disorders

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DJ-1/PARK7 Protein

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1037))

Abstract

In 2003, autosomal recessive loss-of-function mutations were identified in PARK7 gene that caused early-onset Parkinson’s disease (PD). The PARK7 gene encodes a conserved protein termed DJ-1. DJ-1 is a ubiquitous protein, and within the brain, it is present in the nucleus and cytoplasm of both neuronal and glial cells. DJ-1 is a multifunctional protein, and numerous studies have ascribed various roles, including antioxidative properties, chaperone function, protease activities, mitochondrial functions and regulation of transcription to the protein. The DJ-1 protein undergoes oxidation and post-translational modifications that are important for its function. Not only is DJ-1 linked to familial PD, but it is also associated with the pathogenic mechanisms of sporadic PD and other neurodegenerative disorders where oxidative stress is implicated. In this chapter we provide an overview on the expression of DJ-1 mRNA and protein in different neurodegenerative disorders and discuss some of its main functions together with DJ-1’s potential for neuroprotection.

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Acknowledgements

RB is funded by Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology. Part of the work described here was funded by Parkinson’s UK project grant award to RB. This work was supported in part by the Wellcome Trust/MRC joint call in Neurodegeneration award (WT089698) to the UK Parkinson’s Disease Consortium (UKPDC) whose members are from the UCL Institute of Neurology, University of Sheffield and the MRC Protein Phosphorylation Unit Dundee. We also thank Dr. Ian Evans, Department of Medicine UCL Rayne Institute for his critical comments.

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  1. Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1, Wakefield Street, WC1N 1PJ, London, UK

    Daria Antipova & Rina Bandopadhyay

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  1. Daria Antipova
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  2. Rina Bandopadhyay
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Correspondence to Rina Bandopadhyay .

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  1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

    Hiroyoshi Ariga

  2. Faculty of Agriculture, Hokkaido University, Sapporo, Japan

    Sanae M. M. Iguchi-Ariga

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Antipova, D., Bandopadhyay, R. (2017). Expression of DJ-1 in Neurodegenerative Disorders. In: Ariga, H., Iguchi-Ariga, S. (eds) DJ-1/PARK7 Protein. Advances in Experimental Medicine and Biology, vol 1037. Springer, Singapore. https://doi.org/10.1007/978-981-10-6583-5_3

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