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DJ-1 as a Therapeutic Target Against Cancer

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DJ-1/PARK7 Protein

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1037))

Abstract

DJ-1 is a gene involved in various cellular processes, including transcriptional regulation, oxidative stress response, fertilization, mitochondrial regulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1 also plays a critical role in tumor development and progression. In this review, we provide an overview of current knowledge concerning the role and the mechanism of DJ-1 in cancer and also discuss the possibility of DJ-1 as a therapeutic target against cancer.

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Authors and Affiliations

  1. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

    Ji Cao, Xiaobing Chen, Meidan Ying, Qiaojun He & Bo Yang

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  1. Ji Cao
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  2. Xiaobing Chen
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  3. Meidan Ying
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  4. Qiaojun He
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  5. Bo Yang
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Correspondence to Bo Yang .

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Editors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

    Hiroyoshi Ariga

  2. Faculty of Agriculture, Hokkaido University, Sapporo, Japan

    Sanae M. M. Iguchi-Ariga

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Cao, J., Chen, X., Ying, M., He, Q., Yang, B. (2017). DJ-1 as a Therapeutic Target Against Cancer. In: Ariga, H., Iguchi-Ariga, S. (eds) DJ-1/PARK7 Protein. Advances in Experimental Medicine and Biology, vol 1037. Springer, Singapore. https://doi.org/10.1007/978-981-10-6583-5_13

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