Abstract
Mechanotransduction is a general term for all physiological processes through which living cells sense and respond to external and/or internal mechanical stimuli. These stimuli are converted into electrochemical intracellular signals via various mechanosensory transducers eliciting specific cellular responses. Among the many molecular mechanosensors found in living cells, mechanosensitive (MS) ion channels form a group of the fastest signaling molecules essential for cellular mechanotransduction. In this chapter, we discuss the basic principles of ion channel mechanosensitivity and highlight the importance of the surrounding lipid bilayer, cytoskeleton and extracellular matrix. We also discuss how these facets of channel mechanosensitivity may be reduced to changes of the transbilayer pressure profile and MS channel conformations that mutually affect each other according to the ‘force-from-lipids’ paradigm.
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Acknowledgements
N.B. has been supported by a University International Postgraduate Award (UIPA) and P.R. has been supported by a University International Tuition Award (UITA) from the University of New South Wales, whereas Y.N. has been supported by a UIPA from the University of Newcastle. This project was supported by the Australian Research Council and Principal Research Fellowship to B.M. from the National Health and Medical Research Council of Australia. This work was also supported in part by funds from the Office of Health and Medical Research, NSW State Government.
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Bavi, N. et al. (2017). Principles of Mechanosensing at the Membrane Interface. In: Epand, R., Ruysschaert, JM. (eds) The Biophysics of Cell Membranes. Springer Series in Biophysics, vol 19. Springer, Singapore. https://doi.org/10.1007/978-981-10-6244-5_4
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