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Pharmacokinetics of Antimicrobials in Endophthalmitis

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Endophthalmitis

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Abstract

Appropriate ocular pharmacokinetics of antimicrobial agent injected intravitreally for the early treatment of endophthalmitis is the determinant of clinical outcome. Therefore, understanding the growth of microbe inside the eye, its related inflammation which in turn altering the blood ocular barrier functions is important for the activity of antimicrobial agents. Altered antimicrobial drug levels during inflammation can exhibit a profound impact on their pharmacodynamics and it is required to be correlated with a suitable PK/PD model to rationalize the therapy. The extent of inflammation altering blood ocular barriers and type of transporters responsible for the clearance of drugs from the eye along with its antimicrobial PK/PD correlation is analysed in this review. Intravitreal injection of ceftazidime and vancomycin for endopthalmitis has been taken as a prototype to analyse the pharmacokinetic correlation.

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Authors and Affiliations

  1. Ocular Pharmacology and Pharmacy Division, Dr. RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India

    Thirumurthy Velpandian Ph.D. & Madhu Nath Ph.D.

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  1. Thirumurthy Velpandian Ph.D.
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  2. Madhu Nath Ph.D.
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Correspondence to Thirumurthy Velpandian Ph.D. .

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  1. LV Prasad Eye Institute, Hyderabad, India

    Taraprasad Das

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Velpandian, T., Nath, M. (2018). Pharmacokinetics of Antimicrobials in Endophthalmitis. In: Das, T. (eds) Endophthalmitis . Springer, Singapore. https://doi.org/10.1007/978-981-10-5260-6_23

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  • DOI: https://doi.org/10.1007/978-981-10-5260-6_23

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