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Nanocarriers in Drug and Gene Delivery

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Advances in Animal Biotechnology and its Applications

Abstract

Nanotechnology has been vastly explored as a delivery carrier for bioactives. Particles in nanorange show entirely different physical and chemical properties. The unique properties of nanoparticles (NPs) owing to their small size and tunable surface properties make them highly attractive for biomedical applications. NPs have made deep inroad as drug delivery carrier and have embraced the future of effective and efficient delivery of pharmaceuticals. As a drug or gene delivery carrier, NPs improve their pharmacokinetic/pharmacodynamic profile and simultaneously reduce the existing toxic effects. The most fascinating feature of NPs is to improve the stability of liable drugs in vitro and in vivo. Several pharmaceuticals especially genetic materials are prone to be degraded in variable physiological conditions before reaching to the target site. Without proper drug delivery vehicle, they can also impart off-target toxicity and lesser therapeutic efficacy. Nanocarriers represent a number of opportunities to deliver bioactives specifically to the target site by using targeting ligands, surface modification, stimuli responsiveness, intracellular trafficking, and sustained release. To date, a number of nanoparticulate systems based on polymers, lipids, proteins, and inorganic materials have been established for delivery application. Since the last two decades, a tremendous progress has been made in the design and development of more efficient nanoplatforms. NPs have revolutionized the area of drug/gene delivery, and rapid growth in the design of novel nanoplatforms holds great promise in disease therapies.

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References

  • Adams ML, Andes DR, Kwon GS (2003) Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules 4(3):750–757

    Article  PubMed  CAS  Google Scholar 

  • Alivisatos AP (1996) Semiconductor clusters, nanocrystals, and quantum dots. Science 271(5251):933–937

    Article  CAS  Google Scholar 

  • Arias JL (2013) Liposomes in drug delivery: a patent review (2007–present). Expert Opin Ther Pat 23(11):1399–1414

    Article  PubMed  CAS  Google Scholar 

  • Astete CE, Sabliov CM (2006) Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed 17(3):247–289

    Article  PubMed  CAS  Google Scholar 

  • Athanasiou KA, Niederauer GG, Agrawal CM (1996) Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 17:93–102

    Article  PubMed  CAS  Google Scholar 

  • Awada A, Garcia AA, Chan S, Jerusalem HM, Coleman RE, Huizing MT, Mehdi A (2013) Two schedules of etirinotecan pegol (NKTR-102) in patients with previously treated metastatic breast cancer: a randomised phase 2 study. Lancet Oncol 14(12):1216–1225

    Article  PubMed  CAS  Google Scholar 

  • Bae Y, Lee S, Green ES, Park JH, Ko KS, Han J, Choi JS (2016) Characterization of basic amino acids-conjugated PAMAM dendrimers as gene carriers for human adipose-derived mesenchymal stem cells. Int J Pharm 501(1–2):75–86

    Article  PubMed  CAS  Google Scholar 

  • Barik TK, Sahu B, Swain V (2008) Nanosilica-from medicine to pest control. Parasitol Res 103(2):253–258

    Article  PubMed  CAS  Google Scholar 

  • Barratt G, Bretagne S (2007) Optimizing efficacy of Amphotericin B through nanomodification. Int J Nanomedicine 2(3):301–313

    PubMed  PubMed Central  CAS  Google Scholar 

  • Barraud L, Merle P, Soma E, Lefrancois L, Guerret S, Chevallier M, Dubernet C, Couvreur P (2005) Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo. J Hepatol 42(5):736–743

    Article  PubMed  CAS  Google Scholar 

  • Batist G, Ramakrishnan G, Rao CS, Chandrasekharan A, Gutheil J, Guthrie T, Shah P, Khojasteh A, Nair MK, Hoelzer K, Tkaczuk K, Park YC, Lee LW (2001) Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol 19(5):1444–1454

    Article  PubMed  CAS  Google Scholar 

  • Bedikian AY, DeConti RC, Conry R, Agarwala S, Papadopoulos N, Kim KB, Ernstoff M (2011) Phase 3 study of docosahexaenoic acid–paclitaxel versus dacarbazine in patients with metastatic malignant melanoma. Ann Oncol 22(4):787–793

    Article  PubMed  CAS  Google Scholar 

  • Beloqui A, Solinís MÁ, Gascón AR, del Pozo-Rodríguez A, des Rieux A, Préat V (2013) Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier. J Control Release 166:115–123

    Article  PubMed  CAS  Google Scholar 

  • Benezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, Burns A, DeStanchina E, Longo V, Herz E, Iyer S, Wolchok J, Larson SM, Wiesner U, Bradbury MS (2011) Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. J Clin Investig 121(7):2768–2780

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bhandari R, Kaur IP (2013) Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. Int J Pharm 441(1–2):202–212

    Article  PubMed  CAS  Google Scholar 

  • Bissett D, Cassidy J, de Bono JS, Muirhead F, Main M, Robson L, Fraier D, Magnè ML, Pellizzoni C, Porro MG, Spinelli R, Speed W, Twelves C (2004) Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT). Br J Cancer 91(1):50–55

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Booser DJ, Esteva FJ, Rivera E, Valero V, Esparza-Guerra L, Priebe W, Hortobagyi GN (2002) Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer. Cancer Chemother Pharmacol 50(1):6–8

    Article  PubMed  CAS  Google Scholar 

  • Braun GB, Pallaoro A, Wu G, Missirlis D, Zasadzinski JA, Tirrell M, Reich NO (2009) Laser-activated gene silencing via gold nanoshell-siRNA conjugates. ACS Nano 3(7):2007–2015

    Article  PubMed  CAS  Google Scholar 

  • Brown SD, Nativo P, Smith JA, Stirling D, Edwards PR, Venugopal B, Flint DJ, Plumb JA, Graham D, Wheate NJ (2010) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc 132(13):4678–4684

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chan WC, Maxwell DJ, Gao X, Bailey RE, Han M, Nie S (2002) Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 13(1):40–46

    Article  PubMed  CAS  Google Scholar 

  • Chen CC, Tsai TH, Huang ZR, Fang JY (2010) Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. Eur J Pharm Biopharm 74(3):474–482

    Article  PubMed  CAS  Google Scholar 

  • Chytil P, Etrych T, Konák C, Sírová M, Mrkvan T, Ríhová B, Ulbrich K (2006) Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification. J Control Release 115(1):26–36

    Article  PubMed  CAS  Google Scholar 

  • Cui SH, Zhi DF, Zhao YN, Chen HY, Meng Y, Zhang CM, Zhang SB (2016) Cationic lioposomes with folic acid as targeting ligand for gene delivery. Bioorg Med Chem Lett 26(16):4025–4029

    Article  PubMed  CAS  Google Scholar 

  • Dahan M, Laurence T, Pinaud F, Chemla DS, Alivisatos AP, Sauer M, Weiss S (2001) Time-gated biological imaging by use of colloidal quantum dots. Opt Lett 26(11):825–827

    Article  PubMed  CAS  Google Scholar 

  • Dahan M, Lévi S, Luccardini C, Rostaing P, Riveau B, Triller A (2003) Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302(5644):442–445

    Article  PubMed  CAS  Google Scholar 

  • Dixit V, Van den Bossche J, Sherman DM, Thompson DH, Andres RP (2006) Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug Chem 17(3):603–609

    Article  PubMed  CAS  Google Scholar 

  • Domb AJ, Israel ZH, Elmalak O, Teomim D, Bentolila A (1999) Preparation and characterization of carmustine loaded polyanhydride wafers for treating brain tumors. Pharm Res 16(5):762–765

    Article  PubMed  CAS  Google Scholar 

  • Duffaud F, Borner M, Chollet P, Vermorken JB, Bloch J, Degardin M, Rolland F, Dittrich C, Baron B, Lacombe D, Fumoleau P (2004) Phase II study of OSI-211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck. An EORTC New Drug Development Group study. Eur J Cancer 40(18):2748–2752

    PubMed  CAS  Google Scholar 

  • Duncan R (2006) Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer 6(9):688–701

    Article  PubMed  CAS  Google Scholar 

  • Dutta T, Garg M, Dubey V, Mishra D, Singh K, Pandita D, Singh AK, Ravi AK, Velpandian T, Jain NK (2008) Toxicological investigation of surface engineered fifth generation poly (propyleneimine) dendrimers in vivo. Nanotoxicology 2(2):62–70

    Article  CAS  Google Scholar 

  • Egusquiaguirre SP, Igartua M, Hernández RM, Pedraz JL (2012) Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research. Clin Transl Oncol 14(2):83–93

    Article  PubMed  CAS  Google Scholar 

  • Estanqueiro M, Amaral MH, Conceição J, Sousa Lobo JM (2015) Nanotechnological carriers for cancer chemotherapy: the state of the art. Colloids Surf B Biointerf 126:631–648

    Article  CAS  Google Scholar 

  • Ewe A, Aiqner A (2016) Cationic lipid-coated polyplexes (Lipopolyplexes) for DNA and small RNA delivery. Methods Mol Biol 1445:187–200

    Article  PubMed  CAS  Google Scholar 

  • Faraji AH, Wipf P (2009) Nanoparticles in cellular drug delivery. Bioorg Med Chem 17(8):2950–2962

    Article  PubMed  CAS  Google Scholar 

  • Fasol U, Frost A, Büchert M, Arends J, Fiedler U, Scharr D, Scheuenpflug J, Mross K (2012) Vascular and pharmacokinetic effects of EndoTAG-1 in patients with advanced cancer and liver metastasis. Ann Oncol 23(4):1030–1036

    Article  PubMed  CAS  Google Scholar 

  • Fortuin AS, Meijer H, Thompson LC, Witjes JA, Barentsz JO (2013) Ferumoxtran-10 ultrasmall superparamagnetic iron oxide–enhanced diffusion-weighted imaging magnetic resonance imaging for detection of metastases in normal-sized lymph nodes in patients with bladder and prostate cancer: do we enter the era after extended pelvic lymph node dissection? Eur Urol 64(6):961–963

    Article  PubMed  Google Scholar 

  • Fu Q, Hargrove D, Lu X (2016) Improving paclitaxel pharmacokinetics by using tumor-specific mesoporous silica nanoparticles with intraperitoneal delivery. Nanomedicine 12(7):1951–1959

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gao X, Cui Y, Levenson RM, Chung LWK, Nie S (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22(8):969–976

    Article  PubMed  CAS  Google Scholar 

  • Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K (2014) Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 35(10):3416–3426

    Article  PubMed  CAS  Google Scholar 

  • Ghamande S, Lin CC, Cho DC, Shapiro GI, Kwak EL, Silverman MH, Tseng Y, Kuo MW, Mach WB, Hsu SC, Coleman T, Yang JC, Cheng AL, Ghalib MH, Chuadhary I, Goel S (2014) A phase 1 open-label, sequential dose-escalation study investigating the safety, tolerability, and pharmacokinetics of intravenous TLC388 administered to patients with advanced solid tumors. Investig New Drug 32(3):445–451

    Article  CAS  Google Scholar 

  • Ghazani AA, Lee JA, Klostranec J, Xiang Q, Dacosta RS, Wilson BC, Tsao MS, Chan WC (2006) High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals. Nano Lett 6(12):2881–2886

    Article  PubMed  CAS  Google Scholar 

  • Gillies ER, Frechet JM (2005) Dendrimers and dendritic polymers in drug delivery. Drug Discov Today 10(1):35–43

    Article  PubMed  CAS  Google Scholar 

  • Glantz MJ, Jaeckle KA, Chamberlain MC, Phuphanich S, Recht L, Swinnen LJ, Maria B, LaFollette S, Schumann GB, Cole BF, Howell SB (1999) A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5(11):3394–3402

    PubMed  CAS  Google Scholar 

  • Gref R, Domb A, Quellec P, Blunk T, Muller RH, Verbavatz JM, Langer VR (1995) The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev 16(2):215–233

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gref R, Lück M, Quellec P, Marchand M, Dellacherie E, Harnisch S, Blunk T, Müller RH (2000) Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerf 18(3–4):301–313

    Article  CAS  Google Scholar 

  • Haag R, Kratz F (2006) Polymer therapeutics: concepts and applications. Angew Chem Int Ed Eng 45(8):1198–1215

    Article  CAS  Google Scholar 

  • Hamaguchi T, Matsumura Y, Suzuki M, Shimizu K, Goda R, Nakamura I, Nakatomi I, Yokoyama M, Kataoka K, Kakizoe T (2005) NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer 92(7):1240–1246

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hamaguchi T, Doi T, Eguchi-Nakajima T, Kato K, Yamada Y, Shimada Y, Fuse N, Ohtsu A, Matsumoto S, Takanashi M, Matsumura Y (2010) Phase I study of NK012, a novel SN-38–incorporating micellar nanoparticle, in adult patients with solid tumors. Am Ass Cancer Res 16(20):5058–5066

    CAS  Google Scholar 

  • Han Y, Li Y, Zhang P, Sun J, Li X, Sun X, Kong F (2016) Nanostructured lipid carriers as novel drug delivery system for lung cancer gene therapy. Pharm Dev Technol 21(3):277–281

    Article  PubMed  CAS  Google Scholar 

  • Harada A, Kataoka K (1995) Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments. Macromolecules 28(15):5294–5299

    Article  CAS  Google Scholar 

  • Harada M, Bobe I, Saito H, Shibata N, Tanaka R, Hayashi T, Kato Y (2011) Improved anti-tumor activity of stabilized anthracycline polymeric micelle formulation, NC-6300. Cancer Sci 102(1):192–199

    Article  PubMed  CAS  Google Scholar 

  • Hedgire SS, Mino-Kenudson M, Elmi A, Thayer S, Fernandez-del Castillo C, Harisinghani MG (2014) Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation. Int J Nanomedicine 9:1891–1896

    Article  PubMed  PubMed Central  Google Scholar 

  • Higashihara M, Kinoshita M, Kume S, Teramoto T, Kurokawa K (1991) Inhibition of platelet function by high-density lipoprotein from a patient with apolipoprotein E deficiency. Biochem Biophys Res Commun 181(3):1331–1336

    Article  PubMed  CAS  Google Scholar 

  • Homsi J, Simon GR, Garrett CR, Springett G, De Conti R, Chiappori AA, Munster PN, Burton MK, Stromatt S, Allievi C, Angiuli P, Eisenfeld A, Sullivan DM, Daud AI (2007) Phase I trial of poly-l-glutamate camptothecin (CT-2106) administered weekly in patients with advanced solid malignancies. Am Ass Cancer Res 13(19):5855–5861

    CAS  Google Scholar 

  • Huang HC, Barua S, Sharma G, Dey SK, Rege K (2011) Inorganic nanoparticles for cancer imaging and therapy. J Control Release 155(3):344–357

    Article  PubMed  CAS  Google Scholar 

  • Huber G, Levy J (2001) Development of verteporfin therapy: a collaboration between pharmaceutical companies, device manufacturers and clinical investigators. Semin Ophthalmol 16(4):213–217

    Article  PubMed  CAS  Google Scholar 

  • Jabr-Milane L, van Vlerken L, Devalapally H, Shenoy D, Komareddy S, Bhavsar M, Amiji M (2008) Multi-functional nanocarriers for targeted delivery of drugs and genes. J Control Release 130(2):121–128

    Article  PubMed  CAS  Google Scholar 

  • Jaiswal JK, Mattoussi H, Mauro JM, Simon SM (2003) Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 21(1):47–51

    Article  PubMed  CAS  Google Scholar 

  • Jhaveri AM, Torchilin VP (2014) Multifunctional polymeric micelles for delivery of drugs and siRNA. Front Pharmacol 5:77

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jia LJ, Shen J, Li Z, Zhang D, Zhang Q, Liu G, Zheng D, Tian X (2013) In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes. Int J Pharm 445(1–2):12–19

    Article  PubMed  CAS  Google Scholar 

  • Johari-Ahar M, Barar J, Alizadeh AM, Davaran S, Omidi Y, Rashidi MR (2016) Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells. J Drug Target 24(2):120–133

    Article  PubMed  CAS  Google Scholar 

  • Jones M, Leroux J (1999) Polymeric micelles – a new generation of colloidal drug carriers. Eur J Pharm Biopharm 48(2):101–111

    Article  PubMed  CAS  Google Scholar 

  • Joshi M, Patravale V (2006) Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib. Drug Dev Ind Pharm 32(8):911–918

    Article  PubMed  CAS  Google Scholar 

  • Jung J, Park SJ, Chung HK, Kang HW, Lee SW, Seo MH, Park HJ, Song SY, Jeong SY, Choi EK (2012) Polymeric nanoparticles containing taxanes enhance chemoradiotherapeutic efficacy in non-small cell lung cancer. Int J Radiat Oncol Biol Phys 84(1):77–83

    Article  CAS  Google Scholar 

  • Kanasty R, Dorkin JR, Vegas A, Anderson D (2013) Delivery materials for siRNA therapeutics. Nat Mater 12(11):967–977

    Article  PubMed  CAS  Google Scholar 

  • Kang B, Chang S, Dai Y, Yu D, Chen D (2010) Cell response to carbon nanotubes: size-dependent intracellular uptake mechanism and subcellular fate. Small 6(21):2362–2366

    Article  PubMed  CAS  Google Scholar 

  • Kataoka K, Togawa H, Harada A, Yasungi K, Matsumoto T, Katayose S (1996) Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline. Macromolecules 29(26):8556–8557

    Article  CAS  Google Scholar 

  • Kato K, Chin K, Yoshikawa T, Yamaguchi K, Tsuji Y, Esaki T, Sakai K, Kimura M, Hamaguchi T, Shimada Y, Matsumura Y, Ikeda R (2012) Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer. Investig New Drug 30(4):1621–1627

    Article  CAS  Google Scholar 

  • Kedar U, Phutane P, Shidhaye S, Kadam V (2010) Advances in polymeric micelles for drug delivery and tumor targeting. Nanomed Nanotech Biol Med 6(6):714–729

    Article  CAS  Google Scholar 

  • Khullar P, Singh V, Mahal A, Dave PN, Thakur S, Kaur G, Singh J, Kamboj SS, Bakshi MS (2012) Bovine serum albumin bioconjugated gold nanoparticles: synthesis, hemolysis, and cytotoxicity toward cancer cell lines. J Phys C C 116(15):8834–8843

    Article  CAS  Google Scholar 

  • Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloid Surf B Biointerf 75:1–18

    Article  CAS  Google Scholar 

  • Landen CN, Chavez-Reyes A, Bucana C, Schmandt R, Deavers MT, Lopez-Berestein G, Sood AK (2005) Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 65(15):6910–6918

    Article  PubMed  CAS  Google Scholar 

  • Lee KS, Chung HC, Im SA, Park YH, Kim CS, Kim SB, Rha SY, Lee MY, Ro J (2008) Multicenter phase II trial of Genexol-PM, a cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer. Breast Cancer Res Treat 108(2):241–250

    Article  PubMed  CAS  Google Scholar 

  • Li J, Gupta S, Li C (2013) Research perspectives: gold nanoparticles in cancer theranostics. Quant Imaging Med Surg 3(6):284–291

    PubMed  PubMed Central  Google Scholar 

  • Lian T, Ho RJ (2001) Trends and developments in liposome drug delivery systems. J Pharm Sci 90(6):667–680

    Article  PubMed  CAS  Google Scholar 

  • Libutti SK, Paciotti GF, Byrnes AA, Alexander HR Jr, Gannon WE, Walker M, Seidel GD, Yuldasheva N, Tamarkin L (2010) Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Am Ass Cancer Res 16(24):6139–6149

    CAS  Google Scholar 

  • Lim SB, Banerjee A, Önyüksel H (2012) Improvement of drug safety by the use of lipid-based nanocarriers. J Control Release 163(1):34–45

    Article  PubMed  CAS  Google Scholar 

  • Liu Y, Wu DC, Zhang WD, Jiang X, He CB, Chung TS, Goh SH, Leong KW (2005) Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. Angew Chem Int Ed 44(30):4782–4785

    Article  CAS  Google Scholar 

  • Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H (2008) Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 68(16):6652–6660

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu J, Liong M, Zink JI, Tamanoi F (2007) Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 3(8):1341–1346

    Article  PubMed  CAS  Google Scholar 

  • Luo Q, Zhao J, Zhang X, Pan W (2011) Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm 403(1–2):185–191

    Article  PubMed  CAS  Google Scholar 

  • Luong D, Kesharwani P, Deshmukh R, Mohd Amin MC, Gupta U, Greish K, Iyer AK (2016) PEGylated PAMAM dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. Acta Biomater 43:14–29

    Article  PubMed  CAS  Google Scholar 

  • Madaan A, Singh P, Awasthi A, Verma R, Singh AT, Jaggi M, Mishra SK, Kulkarni S, Kulkarni H (2013) Efficiency and mechanism of intracellular paclitaxel delivery by novel nanopolymer-based tumor-targeted delivery system Nanoxel TM. Clin Transl Oncol 15(1):26–32

    Article  PubMed  CAS  Google Scholar 

  • Madaan K, Kumar S, Poonia N, Lather V, Pandita D (2014) Dendrimers in drug delivery and targeting: drug-dendrimer interactions and toxicity issues. J Pharm Bioallied Sci 6(3):139–150

    Article  PubMed  PubMed Central  Google Scholar 

  • Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A (2013) Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine 9(4):492–503

    Article  PubMed  CAS  Google Scholar 

  • Madani SY, Naderi N, Dissanayake O, Tan A, Seifalian AM (2011) A new era of cancer treatment: carbon nanotubes as drug delivery tools. Int J Nanomedicine 6:2963–2979

    PubMed  PubMed Central  CAS  Google Scholar 

  • Mahalingam D, Nemunaitis JJ, Malik L, Sarantopoulos J, Weitman S, Sankhala K, Hart J, Kousba A, Gallegos NS, Anderson G, Charles J, Rogers JM, Senzer NN, Mita AC (2014) Phase I study of intravenously administered ATI-1123, a liposomal docetaxel formulation in patients with advanced solid tumors. Cancer Chemother Pharmacol 74(6):1241–1250

    Article  PubMed  CAS  Google Scholar 

  • Malmsten M (2013) Inorganic nanomaterials as delivery systems for proteins, peptides, DNA, and siRNA. Curr Opin Colloid Interface Sci 18(5):468–480

    Article  CAS  Google Scholar 

  • Mamot C, Ritschard R, Wicki A, Stehle G, Dieterle T, Bubendorf L, Hilker C, Deuster S, Herrmann R, Rochlitz C (2012) Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study. Lancet Oncol 13(12):1234–1241

    Article  PubMed  CAS  Google Scholar 

  • Manivasagan P, Bharathiraja S, Bui NQ, Jang B, Oh YO, Lim IG, Oh J (2016) Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging. Int J Biol Macromol 91:578–588

    Article  PubMed  CAS  Google Scholar 

  • Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K, Kumar DS (2012) Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. PLoS One 7(3):32616

    Article  CAS  Google Scholar 

  • Matougui N, Boge L, Groo AC, Umerska A, Ringstad L, Bysell H, Saulnier P (2016) Lipid-based nanoformulations for peptide delivery. Int J Pharm 502(1–2):80–97

    Article  PubMed  CAS  Google Scholar 

  • Matsumura Y, Hamaguchi T, Ura T, Muro K, Yamada Y, Shimada Y, Shirao K, Okusaka T, Ueno H, Ikeda M, Watanabe N (2004) Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br J Cancer 91(10):1775–1781

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Maximilien J, Beyazit S, Rossi C, Bui BTS (2015) Nanoparticles in biomedical applications. In: Wegener J (ed) Bioanalytical reviews. Springer, Cham

    Chapter  Google Scholar 

  • Medintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 4(6):435–446

    Article  CAS  PubMed  Google Scholar 

  • Meerum Terwogt JM, ten Bokkel Huinink WW, Schellens JH, Schot M, Mandjes IA, Zurlo MG, Rocchetti M, Rosing H, Koopman FJ, Beijnen JH (2001) Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel. Anti-Cancer Drugs 12(4):315–323

    Article  PubMed  CAS  Google Scholar 

  • Mehnert W, Mader K (2001) Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 47(2–3):165–196

    Article  PubMed  CAS  Google Scholar 

  • Mohamed F, van der Walle CF (2008) Engineering biodegradable polyester particles with specific drug targeting and drug release properties. J Pharm Sci 97(1):71–87

    Article  PubMed  CAS  Google Scholar 

  • Morales CS, Zhang L, Langer R, Farokhzad OC (2009) Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups. Biomaterials 30:2231–2240

    Article  CAS  Google Scholar 

  • Morris B (2003) The components of the wired spanning forest are recurrent. Probab Theory Relat Fields 125(2):259–265

    Article  Google Scholar 

  • Mosqueira VC, Legrand P, Gref R, Heurtault B, Appel M, Barratt G (1999) Interactions between a macrophage cell line (J774A1) and surface-modified poly (D, L-lactide) nanocapsules bearing poly(ethylene glycol). J Drug Target 7(1):65–78

    Article  PubMed  CAS  Google Scholar 

  • Muggia FM, Hainsworth JD, Jeffers S, Miller P, Groshen S, Tan M, Roman L, Uziely B, Muderspach L, Garcia A, Burnett A, Greco FA, Morrow CP, Paradiso LJ, Liang LJ (1997) Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation. J Clin Oncol 15(3):987–993

    Article  PubMed  CAS  Google Scholar 

  • Muller RH, Radtke M, Wissing SA (2002) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 54(Suppl 1):S131–S155

    Article  PubMed  CAS  Google Scholar 

  • Muller RH, Petersen RD, Hommoss A, Pardeike J (2007) Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv Drug Deliv Rev 59(6):522–530

    Article  PubMed  CAS  Google Scholar 

  • Nanjwade BK, Bechra HM, Derkar GK, Manvi FV, Nanjwade VK (2009) Dendrimers: emerging polymers for drug-delivery systems. Eur J Pharm Sci 38(3):185–196

    Article  PubMed  CAS  Google Scholar 

  • Naseri N, Valizadeh H, Milani PZ (2015) Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Ad Pharm Bull 5(3):305–313

    Article  CAS  Google Scholar 

  • Niidome Y, Niidome T, Yamada S, Nakashima (2006) Pulsed-laser induced fragmentation and dissociation of DNA immobilized on gold nanoparticles. Mol Cryst Liq Cryst 445(1):201–206

    Article  CAS  Google Scholar 

  • Oasmia Pharmaceutical AB (2014) Study of paclitaxel in patients with ovarian cancer. Retrieved. https://clinicaltrials.gov/ct2/show/NCT00989131

  • Olbrich C, Bakowsky U, Lehr CM, Müller RH, Kneuer C (2001) Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA. J Control Release 77(3):345–355

    Article  PubMed  CAS  Google Scholar 

  • Onyuksel H, Séjourné F, Suzuki H, Rubinstein I (2006) Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension. Peptides 27(9):2271–2275

    Article  PubMed  CAS  Google Scholar 

  • Pagano L, Cornely OA, Busca A, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Florl CL, Nosari A, Potenza L (2013) Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematologic diseases: a report from the SEIFEM and FUNGISCOPE registries. Haematologica 98(10):127–130

    Article  CAS  Google Scholar 

  • Pan L, He Q, Liu J, Chen Y, Ma M, Zhang L, Shi J (2012) Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles. J Am Chem Soc 134(13):5722–5725

    Article  PubMed  CAS  Google Scholar 

  • Pandita D, Lather V (2015) Silica based nanoparticles for theranostic applications. In: Singh B (ed) NanoBioMedicine vol 3 nanotheranostics. Studium Press LLC, Houston

    Google Scholar 

  • Pandita D, Ahuja A, Lather V, Benjamin B, Dutta T, Velpandian T, Khar RK (2011) Development of lipid-based nanoparticles for enhancing the oral bioavailability of paclitaxel. AAPS PharmSciTech 12(2):712–722

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pandita D, Kumar S, Poonia N, Lather V (2014) Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Res Int 62:1165–1174

    Article  CAS  Google Scholar 

  • Pandita D, Kumar S, Lather V (2015a) Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives. Drug Discov Today 20(1):95–104

    Article  PubMed  CAS  Google Scholar 

  • Pandita D, Poonia N, Lather V (2015b) Mesoporous silica nanoparticles in drug delivery and targeting. In: Singh B (ed) NanoBioMedicine vol 1 nanomedicine. Studium Press LLC, Houston

    Google Scholar 

  • Patel KD, Mahapatra C, Jin GZ, Singh RK, Kim HW (2015) Biocompatible mesoporous nanotubular structured surface to control cell behaviors and deliver bioactive molecules. ACS Appl Mater Interfaces 7(48):26850–26859

    Article  PubMed  CAS  Google Scholar 

  • Pathak A, Patnaik S, Gupta KC (2009) Recent trends in non-viral vector-mediated gene delivery. Biotechnol J 4(11):1559–1572

    Article  PubMed  CAS  Google Scholar 

  • Patnaik A, Papadopoulos KP, Tolcher AW, Beeram M, Urien S, Schaaf LJ, Tahiri S, Bekaii-Saab T, Lokiec FM, Rezaï K, Buchbinder A (2013) Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer. Cancer Chemother Pharmacol 71(6):1499–1506

    Article  PubMed  CAS  Google Scholar 

  • Pattni BS, Chupin VV, Torchilin VP (2015) New developments in liposomal drug delivery. Chem Rev 115(19):10938–10966

    Article  PubMed  CAS  Google Scholar 

  • Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2(12):751–760

    Article  PubMed  CAS  Google Scholar 

  • Perche F, Patel NR, Torchilin VP (2012) Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model. J Control Release 164(1):95–102

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Plummer R, Wilson RH, Calvert H, Boddy AV, Griffin M, Sludden J, Tilby MJ, Eatock M, Pearson DG, Ottley CJ, Matsumura Y, Kataoka K, Nishiya T (2011) A phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. Br J Cancer 104(4):593–598

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Poonia N, Kharb R, Lather V, Deepti P (2016) Nanostructured lipid carriers: versatile oral delivery vehicle. Future Sci OA 2(3):FSO135

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Prados MD, Lamborn K, Yung WK, Jaeckle K, Robins HI, Mehta M, Fine HA, Wen PY, Cloughesy T, Chang S, Nicholas MK, Schiff D, Greenberg H, Junck L, Fink K, Hess K, Kuhn J, North American Brain Tumor Consortium (2006) A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American brain tumor consortium study. Neuro-Oncol 8(2):189–193

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Prato M, Kostarelos K, Bianco A (2008) Functionalized carbon nanotubes in drug design and discovery. Acc Chem Res 41(1):60–68

    Article  PubMed  CAS  Google Scholar 

  • Qian X, Long L, Shi Z, Liu C, Qiu M, Sheng J, Pu P, Yuan X, Ren Y, Kang C (2014) Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. Biomaterials 35(2322):2335

    Google Scholar 

  • Radaic A, de Paula E, de Jesus MB (2015) Factorial design and development of solid lipid nanoparticles (SLN) for gene delivery. J Nanosci Nanotechnol 15(2):1793–1800

    Article  PubMed  CAS  Google Scholar 

  • Rademaker-Lakhai JM, Terret C, Howell SB, Baud CM, De Boer RF, Pluim D, Beijnen JH, Schellens JH, Droz JP (2004) A phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors. Am Ass Cancer Res 10(10):3386–3395

    CAS  Google Scholar 

  • Rawat M, Singh D, Saraf S, Saraf S (2008) Lipid carriers: a versatile delivery vehicle for proteins and peptides. Yakugaku Zasshi 128(2):269–280

    Article  PubMed  CAS  Google Scholar 

  • Rivera E (2003) Liposomal anthracyclines in metastatic breast cancer: clinical update. Oncologist 8(Suppl 2):3–9

    Article  PubMed  CAS  Google Scholar 

  • Roby KF, Niu F, Rajewski RA, Terranova PF (2008) In: Coukos G, Berchuck A, Ozols R (eds) Syngeneic mouse model of epithelial ovarian cancer: effects of nanoparticulate paclitaxel, Nanotax®. Ovarian cancer: state of the art and future directions in translational research. Springer New York, New York, pp 169–181

    Google Scholar 

  • Rodriguez MA, Pytlik R, Kozak T, Chhanabhai M, Gascoyne R, Lu B, Deitcher SR, Winter JN, Marqibo Investigators (2009) Vincristine sulfate liposomes injection (Marqibo) in heavily pretreated patients with refractory aggressive non-Hodgkin lymphoma: report of the pivotal phase 2 study. Cancer 115(15):3475–3482

    Article  PubMed  CAS  Google Scholar 

  • Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AKR, Han MS, Mirkin CA (2006) Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 312(5776):1027–1030

    Article  PubMed  CAS  Google Scholar 

  • Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N, Prasad PN (2005) Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery. Proc Natl Acad Sci U S A 102(2):279–284

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rudzinski WE, Palacios A, Ahmed A, Lane MA, Aminabhavi TM (2016) Targeted delivery of small interfering RNA to colon cancer cells using chitosan and PEGylated chitosan nanoparticles. Carbohydr Polym 147:323–332

    Article  PubMed  CAS  Google Scholar 

  • Sabbatini P, Aghajanian C, Dizon D, Anderson S, Dupont J, Brown JV, Peters WA, Jacobs A, Mehdi A, Rivkin S, Eisenfeld AJ, Spriggs D (2004) Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. J Clin Oncol 22(22):4523–4531

    Article  PubMed  CAS  Google Scholar 

  • Samad A, Sultana Y, Aqil M (2007) Liposomal drug delivery systems: an update review. Curr Drug Deliv 4(4):297–305

    Article  PubMed  CAS  Google Scholar 

  • Santos JL, Oliveira H, Pandita D, Rodrigues J, Pêgo AP, Granja PL, Tomás H (2010) Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells. J Control Release 144(1):55–64

    Article  PubMed  CAS  Google Scholar 

  • Sarkar A, Ghosh S, Chowdhury S, Pandey B, Sil PC (2016) Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells. Biochim Biophys Acta 1860(10):2065–2075

    Article  PubMed  CAS  Google Scholar 

  • Scott LC, Yao JC, Thomas AL, Falk S, Mena RR, Picus J, Wright J, Mulcahy MF, Ajani JA, Evans TR (2009) A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma. Cancer Chemother Pharmacol 63(2):363–370

    Article  PubMed  CAS  Google Scholar 

  • Sekhon BS, Kamboj SR (2014) Inorganic nanomedicine-Part 2. Nanomed Nanotechnol Biol Med 6(5):612–618

    Article  CAS  Google Scholar 

  • Seymour LW, Ferry DR, Anderson D, Hesslewood S, Julyan PJ, Poyner R, Doran J, Young AM, Burtles S, Kerr DJ (2002) Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin. J Clin Oncol 20(6):1668–1676

    Article  PubMed  CAS  Google Scholar 

  • Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86(3):215–223

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Singh R, Pantarotto D, McCarthy D, Chaloin O, Hoebeke J, Partidos CD, Briand JP, Prato M, Bianco A, Kostarelos K (2005) Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J Am Chem Soc 127(12):4388–4396

    Article  PubMed  CAS  Google Scholar 

  • Slingerland M, Guchelaar HJ, Rosing H, Scheulen ME, van Warmerdam LJ, Beijnen JH, Gelderblom H (2013) Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer. Clin Ther 35(12):1946–1954

    Article  PubMed  CAS  Google Scholar 

  • Soepenberg O, de Jonge MJ, Sparreboom A, de Bruin P, Eskens FA, de Heus G, Wanders J, Cheverton P, Ducharme MP, Verweij J (2005) Phase I and pharmacokinetic study of DE-310 in patients with advanced solid tumors. Am Ass Cancer Res 11(2):703–711

    CAS  Google Scholar 

  • Sonali SRP, Sharma G, Kumari L, Koch B, Singh S, Bharti S, Rajinikanth PS, Pandey BL, Muthu MS (2016) RGD-TPGS decorated theranostic liposomes for brain targeted delivery. Colloids Surf B Biointerf 147:129–141

    Article  CAS  Google Scholar 

  • Stevens JM, Auer J, Strong CA, Hughes RT, Oliver DO, Winearls CG, Cotes PM (1991) Stepwise correction of anaemia by subcutaneous administration of human recombinant erythropoietin in patients with chronic renal failure maintained by continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 6(7):487–494

    Article  PubMed  CAS  Google Scholar 

  • Sugii M, Suzuki R, Oda Y, Unga J, Omata D, Urunga H, Negishi Y, Maruyama K (2016) Development of cell-targeting bubble liposome for effective gene delivery with ultrasound. Asian J Pharm Sci 11(1):146–147

    Article  Google Scholar 

  • Sun J, Bi C, Chan HM, Sun S, Zhang Q, Zheng Y (2013) Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids Surf B Biointerf 111:367–375

    Article  CAS  Google Scholar 

  • Suwalski A, Dabboue H, Delalande A, Bensamoun SF, Canon F, Midoux P, Saillant G, Klatzmann D, Salvetat JP, Pichon C (2010) Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles. Biomaterials 31(19):5237–5245

    Article  PubMed  CAS  Google Scholar 

  • Sweety K, Deepti P, Poonia N, Lather V (2015) Nanostructured lipid carriers for topical delivery of an anti-acne drug: characterization and ex vivo evaluation. Pharm Nanotechnol 3(2):122–133

    Article  CAS  Google Scholar 

  • Tabernero J, Shapiro GI, LoRusso PM, Cervantes A, Schwartz GK et al (2013) First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov 3(4):406–417

    Article  PubMed  CAS  Google Scholar 

  • Tan GR, Fenq SS, Leong DT (2014) The reduction of anti-cancer drug antagonism by the spatial protection of drugs with. PLA-TPGS Nanopart Biomater 35(9):3044–3051

    CAS  Google Scholar 

  • Thassu D, Deleers M, Pathak YV (2007) Nanoparticulate drug delivery systems. CRC Press, Boca Raton

    Book  Google Scholar 

  • Ueno T, Endo K, Hori K, Ozaki N, Tsuji A, Kondo S, Wakisaka N, Murono S, Kataoka K, Kato Y, Yoshizaki T (2014) Assessment of antitumor activity and acute peripheral neuropathy of 1, 2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016). Int J Nanomedicine 9:3005–3012

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Uner M, Yener G (2007) Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomedicine 2(3):289–300

    PubMed  PubMed Central  CAS  Google Scholar 

  • Uriarte-Pinto MÁ, Escolano-Pueyo Á, Gimeno-Ballester V, Pascual-Martínez O, Abad-Sazatornil MR, Agustín-Ferrández MJ (2016) Trastuzumab, non-pegylated liposomal-encapsulated doxorubicin and paclitaxel in the neoadjuvant setting of HER-2 positive breast cancer. Int J Clin Pharm 38(2):446–453

    Article  PubMed  CAS  Google Scholar 

  • Vallet-Regi MF, Balas F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem Int Ed Eng l46(40):7548–7558

    Article  CAS  Google Scholar 

  • Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J (1999) Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin Cancer Res 5(1):83–94

    PubMed  CAS  Google Scholar 

  • Venkatakrishnan K, Liu Y, Noe D, Mertz J, Bargfrede M, Marbury T, Farbakhsh K, Oliva C, Milton A (2014) Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or moderate hepatic impairment. Br J Clin Pharmacol 77(6):998–1010

    Article  PubMed  CAS  Google Scholar 

  • Vivero-Escoto JL, Slowing II, Trewyn BG, Lin VS (2010) Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small 6(18):1952–1967

    Article  PubMed  CAS  Google Scholar 

  • Wang YXJ (2011) Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application. Quant Imaging Med Surg 1(1):35–40

    PubMed  PubMed Central  Google Scholar 

  • Wang M, Thanou M (2010) Targeting nanoparticles to cancer. Pharmacol Res 62(2):90–99

    Article  PubMed  CAS  Google Scholar 

  • Wang F, Wang YC, Dou S, Xiong MH, Sun TM, Wang J (2011) Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 5(5):3679–3692

    Article  PubMed  CAS  Google Scholar 

  • Weber S, Niemirowicz K, Markiewicz KH, Car H (2014) Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharm Biopharm 86(1):7–22

    Article  PubMed  CAS  Google Scholar 

  • Wilczewska AZ, Niemirowicz K (2012) Nanoparticles as drug delivery systems. Pharmacol Rep 64(5):1020–1037

    Article  CAS  PubMed  Google Scholar 

  • Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, Hung MC (2007) Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell 12(1):52–65

    Article  PubMed  CAS  Google Scholar 

  • Yang F, Jin C, Subedi S, Lee CL, Wang Q, Jiang Y, Li J, Di Y, Fu D (2012) Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment. Cancer Treat Rev 38(6):566–579

    Article  PubMed  CAS  Google Scholar 

  • Yang XY, Li YX, Li M, Zhang L, Feng LX, Zhang N (2013) Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer. Cancer Lett 334(2):338–345

    Article  PubMed  CAS  Google Scholar 

  • Yang HN, Park JS, Jeon SY, Park W, Na K, Park KH (2014) The effect of quantum dot size and poly(ethylenimine) coating on the efficiency of gene delivery into human mesenchymal stem cells. Biomaterials 35(29):8439–8449

    Article  PubMed  CAS  Google Scholar 

  • Yu GS, Bae YM, Choi H, Kong B, Choi IS, Choi JS (2011) Synthesis of PAMAM dendrimer derivatives with enhanced buffering capacity and remarkable gene transfection efficiency. Bioconjug Chem 22(6):1046–1055

    Article  PubMed  CAS  Google Scholar 

  • Yu YH, Kim E, Park DE, Shim G, Lee S, Kim YB, Kim CW, Oh YK (2012) Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm 80(2):268–273

    Article  PubMed  CAS  Google Scholar 

  • Yu K, Zhao J, Zunkai Z, Yin G, Yulin Z, Lesheng T, Li Y (2015) Enhanced delivery of paclitaxel using electrostatically-conjugated Herceptin-bearing PEI/PLGA nanoparticles against HER-positive breast cancer cells. Int J Pharm 497(1–2):78–87

    PubMed  Google Scholar 

  • Yurkovetskiy AV, Fram RJ (2009) XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer. Adv Drug Deliv Rev 61(13):1193–1202

    Article  PubMed  CAS  Google Scholar 

  • Zhai Y, Zhai G (2014) Advances in lipid-based colloid systems as drug carrier for topic delivery. J Control Release 193:90–99

    Article  PubMed  CAS  Google Scholar 

  • Zhang Chen Z, Song X, Si J, Tang G (2008) Low generation polypropylenimine dendrimer graft beta-cyclodextrin: an efficient vector for gene delivery system. Technol Cancer Res Treat 7(2):103–108

    Article  Google Scholar 

  • Zhang B, Wang T, Yang S, Xiao Y, Song Y, Zhang N, Garg S (2016a) Development and evaluation of oxaliplatin and irinotecan co-loaded liposomes for enhanced colorectal cancer therapy. J Control Release 238:10–21

    Article  PubMed  CAS  Google Scholar 

  • Zhang J, Sun Y, Tian B, Li K, Wang L, Liang Y, Han J (2016b) Multifunctional mesoporous silica nanoparticles modified with tumor-shedable hyaluronic acid as carriers for doxorubicin. Colloids Surf B Biointerf 144:293–302

    Article  CAS  Google Scholar 

  • Zhao X, Sun X, Zeng L, Liu J, Zhang Z (2015) Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipidpolymer hybrid nanoparticles for effective treatment of pancreatic cancer. Biomaterials 46:13–25

    Article  PubMed  CAS  Google Scholar 

  • Zhou Q, Sun X, Zheng L, Liu J, Zhang Z (2009) A randomized multicenter phase II clinical trial of mitoxantrone-loaded nanoparticles in the treatment of 108 patients with unresected hepatocellular carcinoma. Nanomed Nanotechnol Biol Med 5(4):419–423

    Article  CAS  Google Scholar 

  • Zhu D, Tao W, Zhang H, Liu G, Wang T, Zhang L, Zeng X, Mei L (2015) Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer. Acta Biomater 30:144–154

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa, Haryana, India

    Deepti Pandita, Aman Munjal & Sandeep Godara

  2. Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa, Haryana, India

    Viney Lather

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  1. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Suresh Kumar Gahlawat

  2. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Joginder Singh Duhan

  3. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Raj Kumar Salar

  4. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Priyanka Siwach

  5. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Suresh Kumar

  6. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Pawan Kaur

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Pandita, D., Munjal, A., Godara, S., Lather, V. (2018). Nanocarriers in Drug and Gene Delivery. In: Gahlawat, S., Duhan, J., Salar, R., Siwach, P., Kumar, S., Kaur, P. (eds) Advances in Animal Biotechnology and its Applications. Springer, Singapore. https://doi.org/10.1007/978-981-10-4702-2_6

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