Skip to main content

ERCP for Pancreatic Disorders

  • Chapter
  • First Online:
Biliopancreatic Endoscopy
  • 799 Accesses

Abstract

Endoscopic retrograde cholangiopancreatography (ERCP) is now widely used both in the diagnosis and treatment of a variety of pancreatic diseases. With advances in techniques, pancreatic endotherapy has been gaining popularity in the treatment of a myriad of pancreatic disorders including chronic pancreatitis, pancreatic duct stones, pancreatic duct leaks or disruptions, drainage of pseudocysts, and the prevention of pancreatitis following ERCP. The most common pancreatic endotherapeutic procedures are pancreatic sphincterotomy and stenting. Pancreatic sphincterotomy is a high-risk and technically demanding procedure. Stenting of the main pancreatic duct is particularly useful in relieving ductal obstruction, often in the setting of refractory pain from strictures, stones, or papillary stenosis. The role of pancreatic stents in preventing ERCP-induced pancreatitis has also been established. Additionally, stenting of the minor papilla has been used in the treatment of symptomatic pancreas divisum due to a stenotic minor papilla. Pancreatic duct stricture dilation is another important procedure for obstructive pancreatic disorders. The indications and techniques related to pancreatic sphincterotomy, stenting, and pancreatic duct dilation are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stimec B, Bulajic M, Korneti V, et al. Ductal morphometry of ventral pancreas in pancreas divisum. Comparison between clinical and anatomical results. Ital J Gastroenterol. 1996;28(2):76–80.

    CAS  PubMed  Google Scholar 

  2. Delhaye M, Cremer M. Clinical significance of pancreas divisum. Acta Gastroenterol Belg. 1992;55(3):306–13.

    CAS  PubMed  Google Scholar 

  3. Bertin C, Pelletier AL, Vullierme MP, et al. Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations. Am J Gastroenterol. 2012;107(2):311–7.

    Article  CAS  PubMed  Google Scholar 

  4. Adibelli ZH, Adatepe M, Isayeva L, et al. Pancreas divisum: a risk factor for pancreaticobiliary tumors - an analysis of 1628 MR cholangiography examinations. Diagn Interv Imaging. 2017;98(2):141–7.

    Article  CAS  PubMed  Google Scholar 

  5. Misra SP, Gulati P, Thorat VK, et al. Pancreaticobiliary ductal union in biliary diseases. An endoscopic retrograde cholangiopancreatographic study. Gastroenterology. 1989;96(3):907–12.

    Article  CAS  PubMed  Google Scholar 

  6. Kimura K, Ohto M, Saisho H, et al. Association of gallbladder carcinoma and anomalous pancreaticobiliary ductal union. Gastroenterology. 1985;89(6):1258–65.

    Article  CAS  PubMed  Google Scholar 

  7. Sameshima Y, Muto Y, Uchimura M, et al. Clinicopathological study of the gallbladder in congenital dilatation of the bile duct--with special reference to the association with cancer. Nihon Shokakibyo Gakkai Zasshi. 1982;79(5):1129–36.

    CAS  PubMed  Google Scholar 

  8. Jones SN, Lees WR, Frost RA. Diagnosis and grading of chronic pancreatitis by morphological criteria derived by ultrasound and pancreatography. Clin Radiol. 1988;39(1):43–8.

    Article  CAS  PubMed  Google Scholar 

  9. Bozkurt T, Braun U, Leferink S, et al. Comparison of pancreatic morphology and exocrine functional impairment in patients with chronic pancreatitis. Gut. 1994;35(8):1132–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Axon AT, Classen M, Cotton PB, et al. Pancreatography in chronic pancreatitis: international definitions. Gut. 1984;25(10):1107–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Drake DH, Fry WJ. Ductal drainage for chronic pancreatitis. Surgery. 1989;105(2 Pt 1):131–40.

    CAS  PubMed  Google Scholar 

  12. Bradley EL 3rd. Pancreatic duct pressure in chronic pancreatitis. Am J Surg. 1982;144(3):313–6.

    Article  PubMed  Google Scholar 

  13. Reber HA, Karanjia ND, Alvarez C, et al. Pancreatic blood flow in cats with chronic pancreatitis. Gastroenterology. 1992;103(2):652–9.

    Article  CAS  PubMed  Google Scholar 

  14. Delhaye M, Vandermeeren A, Baize M, et al. Extracorporeal shock-wave lithotripsy of pancreatic calculi. Gastroenterology. 1992;102(2):610–20.

    Article  CAS  PubMed  Google Scholar 

  15. Kang MJ, Jang JY, Chang YR, et al. Revisiting the concept of lymph node metastases of pancreatic head cancer: number of metastatic lymph nodes and lymph node ratio according to N stage. Ann Surg Oncol. 2014;21(5):1545–51.

    Article  PubMed  Google Scholar 

  16. Niederau C, Grendell JH. Diagnosis of pancreatic carcinoma. Imaging techniques and tumor markers. Pancreas. 1992;7(1):66–86.

    Article  CAS  PubMed  Google Scholar 

  17. DeWitt J, Misra VL, Leblanc JK, et al. EUS-guided FNA of proximal biliary strictures after negative ERCP brush cytology results. Gastrointest Endosc. 2006;64(3):325–33.

    Article  PubMed  Google Scholar 

  18. Adamek HE, Albert J, Breer H, et al. Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. Lancet. 2000;356(9225):190–3.

    Article  CAS  PubMed  Google Scholar 

  19. Deviere J, Bueso H, Baize M, et al. Complete disruption of the main pancreatic duct: endoscopic management. Gastrointest Endosc. 1995;42(5):445–51.

    Article  CAS  PubMed  Google Scholar 

  20. Kozarek RA, Ball TJ, Patterson DJ, et al. Transpapillary stenting for pancreaticocutaneous fistulas. J Gastrointest Surg. 1997;1(4):357–61.

    Article  CAS  PubMed  Google Scholar 

  21. Kozarek RA, T. L. Endoscopic treatment of chronic pancreatitis: an alternative to surgery? Dig Surg. 1996;13:90.

    Article  Google Scholar 

  22. Wolfsen HC, Kozarek RA, Ball TJ, et al. Pancreaticoenteric fistula: no longer a surgical disease? J Clin Gastroenterol. 1992;14(2):117–21.

    Article  CAS  PubMed  Google Scholar 

  23. Seewald S, Brand B, Groth S, et al. Endoscopic sealing of pancreatic fistula by using N-butyl-2-cyanoacrylate. Gastrointest Endosc. 2004;59(4):463–70.

    Article  PubMed  Google Scholar 

  24. Turner BG, Brugge WR. Diagnostic and therapeutic endoscopic approaches to intraductal papillary mucinous neoplasm. World J Gastrointest Surg. 2010;2(10):337–41.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Sai JK, Nobukawa B, Matsumura Y, et al. Pancreatic duct lavage cytology with the cell block method for discriminating benign and malignant branch-duct type intraductal papillary mucinous neoplasms. Gastrointest Endosc. 2013;77(5):726–35.

    Article  PubMed  Google Scholar 

  26. Yamaguchi T, Hara T, Tsuyuguchi T, et al. Peroral pancreatoscopy in the diagnosis of mucin-producing tumors of the pancreas. Gastrointest Endosc. 2000;52(1):67–73.

    Article  CAS  PubMed  Google Scholar 

  27. Yasuda K, Sakata M, Ueda M, et al. The use of pancreatoscopy in the diagnosis of intraductal papillary mucinous tumor lesions of the pancreas. Clin Gastroenterol Hepatol. 2005;3(7 Suppl 1):S53–7.

    Article  PubMed  Google Scholar 

  28. Furukawa T, Tsukamoto Y, Naitoh Y, et al. Differential diagnosis between benign and malignant localized stenosis of the main pancreatic duct by intraductal ultrasound of the pancreas. Am J Gastroenterol. 1994;89(11):2038–41.

    CAS  PubMed  Google Scholar 

  29. Dumonceau JM, Delhaye M, Tringali A, et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2012;44(8):784–800.

    Article  PubMed  Google Scholar 

  30. Somogyi L, Chuttani R, Croffie J, et al. Biliary and pancreatic stents. Gastrointest Endosc. 2006;63(7):910–9.

    Article  PubMed  Google Scholar 

  31. Ikenberry SO, Sherman S, Hawes RH, et al. The occlusion rate of pancreatic stents. Gastrointest Endosc. 1994;40(5):611–3.

    Article  CAS  PubMed  Google Scholar 

  32. Bakman YG, Safdar K, Freeman ML. Significant clinical implications of prophylactic pancreatic stent placement in previously normal pancreatic ducts. Endoscopy. 2009;41(12):1095–8.

    Article  CAS  PubMed  Google Scholar 

  33. Lawrence C, Cotton PB, Romagnuolo J, et al. Small prophylactic pancreatic duct stents: an assessment of spontaneous passage and stent-induced ductal abnormalities. Endoscopy. 2007;39(12):1082–5.

    Article  CAS  PubMed  Google Scholar 

  34. Ziebert JJ, DiSario JA. Dilation of refractory pancreatic duct strictures: the turn of the screw. Gastrointest Endosc. 1999;49(5):632–5.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cheuk-Kay Sun M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sun, CK. (2018). ERCP for Pancreatic Disorders. In: Lai, KH., Mo, LR., Wang, HP. (eds) Biliopancreatic Endoscopy. Springer, Singapore. https://doi.org/10.1007/978-981-10-4367-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-4367-3_9

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4366-6

  • Online ISBN: 978-981-10-4367-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics