Association Between Single Nucleotide Polymorphism Rs11614913 (C>T) on Mir-196a2 and Breast Cancer in Vietnamese Population

Abstract

Breast cancer (BC) is a major health problem throughout the world. It is one of the most common cancer among women both in developed and developing countries. To raise the survival of BC patients, genetic factors are used for early diagnosis because they are non-changed factors and give ability of cells to proliferate and metastasize. MiR-196a2 targets many genes which are vital for development, apoptosis, differentiation, motility and angiogenesis. The SNP rs11614913 (C/T) affects the processing of the pre-miRNA to its mature form and the ability to regulate target genes. This SNP has been demonstrated to relate to breast cancer in Asian, especially in Chinese [OR (95% CI) = 0.73 (0.57–0.93), p = 0.011]. This study aimed to investigate the correlation between the SNP rs11614913 and BC in Vietnamese population. 113 cases and 127 controls were genotyped using optimized high resolution melting method (HRM) then statistical analysis was applied to examine the association of the SNP. The results show that the frequencies of TT, CT, and CC were 26.54, 30.97 and 42.49% in cases group and 25.19, 50.39, and 24.42% in controls group, respectively. Statistic result revealed an obvious decreased risk of BC among Vietnamese population when compared of heterozygote model and dominant model (CT vs. CC: OR = 0.35, 95% CI: 0.19–0.65, p = 0.00074; TT + CT vs. CC: OR = 0.44, 95% CI: 0.25–0.76, p = 0.00295). Our results shown that rs11614913 could be a potential biomarker for early detection and diagnosis of breast cancer for Vietnamese patients.