Abstract
Background The surgical placement of implants into maxillary extraction sites in ovariectomized (OVX) rats could mimic implant placement in compromised bone in humans, such as is seen in osteoporosis. Purpose This study was designed to evaluate the effects of osteoporosis on osseo-integration around titanium implants following extraction in the posterior maxilla of OVX rats. Materials and Methods Forty-four 3 month old female Sprague-Dawley rats were used in this study. The rats were randomly divided into two groups: Sham-operated group (SHAM; n = 22) and ovariectomized group (OVX; n = 22). Surface-treated screw-shaped titanium implants were immediately inserted into the mesial extraction sites of the first molar in the posterior maxilla following tooth extraction. The animals were sacrificed at either 28 or 56 days post-surgery, and undecalcified tissue sections were processed for histological analysis. Bone-to-implant contact (BIC) and bone density (BD) were evaluated. Results With a carefully planned and executed surgical implant protocol, implant placement following extraction in the posterior maxilla can produce reproducible results. The BIC and BD in the OVX group were significantly inferior to those in the SHAM group at both 28 and 56 days, which indicated that osteoporosis could reduce the amount of osseo-integration of dental implants in the posterior maxilla. Conclusion This study demonstrated that osseo-integration (BIC and BD) was inferior in implants following extraction in the posterior maxilla of OVX rats, especially in the early healing period, indicating that lower local bone quality in OVX rats can reduce early bone formation on implant surfaces.
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References
Brodala N (2009) Flapless surgery and its effect on dental implant outcomes. Int J Oral Maxillofac Implant 24(Suppl):118–125
Doan N et al (2012) Is flapless implant surgery a viable option in posterior maxilla? A review. Int J Oral Maxillofac Surg 41(9):1064–1071
Du Z et al (2012) Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin. Clin Oral Implant Res 23(10):1232–1237
Le Guehennec L et al (2007) Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater Off Publ Acad Dent Mater 23(7):844–854
Balshi TJ, Wolfinger GJ (2000) Management of the posterior maxilla in the compromised patient: historical, current, and future perspectives. Periodontology 33(2003):67–81
Misch CE (2001) The importance of dental implants. Gen Dentist 49(1):38–45
Rodoni LR et al (2005) Implants in the posterior maxilla: a comparative clinical and radiologic study. Int J Oral Maxillofac Implant 20(2):231–237
Beppu K et al (2013) Peri-implant bone density in senile osteoporosis-changes from implant placement to osseointegration. Clin Implant Dent Relat Res 15(2):217–226
Dao TT, Anderson JD, Zarb GA (1993) Is osteoporosis a risk factor for osseointegration of dental implants? Int J Oral Maxillofac Implants 8(2):137–144
Shibli JA et al (2008) Evaluation of human bone around a dental implant retrieved from a subject with osteoporosis. Gen Dent 56(1):64–67
Shibli JA et al (2008) Histologic analysis of human peri-implant bone in type 1 osteoporosis. J Oral Implantol 34(1):12–16
Yamazaki M et al (1999) Bone reactions to titanium screw implants in ovariectomized animals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87(4):411–418
Motohashi M et al (1999) Bone reactions around hydroxyapatite-coated implants in ovariectomized rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87(2):145–152
Lugero GG et al (2000) Histomorphometric evaluation of titanium implants in osteoporotic rabbits. Implant Dent 9(4):303–309
Pan J et al (2000) Effect of ovariectomy on bone remodeling adjacent to hydroxyapatite-coated implants in the tibia of mature rats. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 58(8):877–882
Du Z et al (2009) Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implant Res 20(2):145–150
Astrand J, Nilsson J, Thorngren KG (2012) Screening for osteoporosis reduced new fracture incidence by almost half. Acta Orthop 83(6):661–665
Wang N et al (2011) Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs. Biomaterials 32(29):6900–6911
Mombelli A, Cionca N (2006) Systemic diseases affecting osseointegration therapy. Clin Oral Implants Res 17(Suppl 2):97–103
Acknowledgements
This research is a collaboration effort from Queensland University of Technology, Australia, Griffith University, Australia, and Fujian Medical University, China, the ITI Foundation, Switzerland, the Australian Dental Research Foundation, and the kind donation by Southern Implant® of the implants used in this study.
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The authors declare that they have no conflict of interest.
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Doan, N. et al. (2018). An Evaluation on the Effect of Osteoporosis on Osseointegration Around Titanium Implants in Posterior Maxilla Following a Tooth Extraction. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_103
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DOI: https://doi.org/10.1007/978-981-10-4361-1_103
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