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Sexually Transmitted Infections and Male Infertility: Old Enigma, New Insights

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Male Infertility: Understanding, Causes and Treatment

Abstract

Sexually transmitted diseases (STDs) are caused by bacteria, viruses, or parasites that are transmitted through venereal contact. The major STDs causing bacterial infections include Chlamydia trachomatis (chlamydiasis), Neisseria gonorrhoeae (gonorrhea), Treponema pallidum (syphilis), Mycoplasma, and Ureaplasma species. On the other hand, the major viral STD infections include herpes simplex virus (HSV), human papillomavirus (HPV), human immunodeficiency virus (HIV), human cytomegalovirus (HCV), and hepatitis B and C viruses. Similarly, the major parasite infecting the genital tract is the protozoan Trichomonas vaginalis, which causes trichomoniasis. In males, these STDs may either be asymptomatic or cause urethritis, epididymitis, orchitis, vasiculitis, and prostatitis. Most of these infections have been shown to affect male fertility by affecting semen parameters like sperm count, motility, and morphology; however, their exact mechanism of action is still not known. The presence of infection(s) on sperm and/or in the seminal plasma causes their horizontal transmission to sexual partners and vertical transmission to offsprings. This chapter briefly reviews some of the published literature on major STDs in relation to male infertility and relevant treatment strategies. (CDRI communication number 9456)

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References

  • Abdulmedzhidova AG et al. (2007) Asymptomatic genital herpes infection and infertility in males [Russian]. Urologiia 56–59

    Google Scholar 

  • Abusarah EA, Awwad ZM, Charvalos E, Shehabi AA (2013) Molecular detection of potential sexually transmitted pathogens in semen and urine specimens of infertile and fertile males. Diagn Microbiol Infect Dis 77:283–286

    Article  PubMed  Google Scholar 

  • Akre O, Cnattingius S, Bergström R, Kvist U, Trichopoulos D, Ekbom A (1999) Human fertility does not decline: evidence from Sweden. Fertil Steril 71(6):1066–1069

    Article  CAS  PubMed  Google Scholar 

  • Alcalde E, Perez-Garcia L, Dinares I, Coombs GH, Frigola J (1992) Synthesis and antitrichomonal activity of azinium (azolium) 4-nitrobenzimidazolate betaines and their derivatives. Eur J Med Chem 27(2):171–176

    Article  CAS  Google Scholar 

  • Alexander J, Kowdley KV (2006) Epidemiology of hepatitis B—clinical implications. Medscape general. Medicine 8(2):13

    CAS  Google Scholar 

  • Alidina Z, Wormsbecker AE, Urquia M, MacGillivray J, Tork E, Yudin MH, Campbell DM (2016) HIV prophylaxis in high risk newborns: an examination of sociodemographic factors in an inner city context. Can J Infect Dis Med Microbiol 2016

    Google Scholar 

  • Allahbadia GN (2016) Yes, it is possible. J Obstet Gynecol India 66(3):139–143

    Article  CAS  Google Scholar 

  • Al-Sweih NA, Al-Fadli AH, Omu AE, Rotimi VO (2012) Prevalence of Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum infections and seminal quality in infertile and fertile men in Kuwait. J Androl 33:1323–1329

    Article  CAS  PubMed  Google Scholar 

  • Anderson RA, Feathergill KA, Diao XH, Cooper MD, Kirkpatrick R, Herold BC, Doncel GF, Chany CJ, Waller DP, Rencher WF, Zaneveld LJ (2002) Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent. J Androl 23(3):426–438

    CAS  PubMed  Google Scholar 

  • Andrade-Rocha FT (2003) Ureaplasma urealyticum and Mycoplasma hominis in men attending for routine semen analysis. Prevalence, incidence by age and clinical settings, influence on sperm characteristics, relationship with the leukocyte count and clinical value. Urol Int 71:377–381

    Article  PubMed  Google Scholar 

  • Anthwal A, Rajesh UC, Rawat MSM, Kushwaha B, Maikhuri JP, Sharma VL, Gupta G, Rawat DS (2014) Novel metronidazole–chalcone conjugates with potential to counter drug resistance in trichomonas vaginalis. Eur J Med Chem 79:89–94

    Article  CAS  PubMed  Google Scholar 

  • Apari P, de Sousa JD, Müller V (2014) Why sexually transmitted infections tend to cause infertility: an evolutionary hypothesis. PLoS Pathog 10(8):e1004111

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Aspinall EJ, Hawkins G, Fraser A, Hutchinson SJ, Goldberg D (2011) Hepatitis B prevention, diagnosis, treatment and care: a review. Occup Med 61(8):531–540

    Article  CAS  Google Scholar 

  • Atienza J, Diaz RAM, Barrio A, Escario JA, Herrero A, Ochoa C, Rodríguez J (1992) Activity assays of thiadiazine derivatives on trichomonas vaginalis and amastigote forms of Trypanosoma cruzi. Chemotherapy 38(6):441–446

    Article  CAS  PubMed  Google Scholar 

  • Bagasra O, Freund M, Weidmann J, Harley G (1988) Interaction of human immunodeficiency virus with human sperm in vitro. J Acquir Immune Defic Syndr 1:431–435

    CAS  PubMed  Google Scholar 

  • Bagasra O et al (1994) Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men. AIDS 8:1669–1674

    Article  CAS  PubMed  Google Scholar 

  • Baird A, Olarinde O, Talbot M (2007) Evaluation, using two assessment instruments, of the American and British national guidelines for the management of sexually transmissible and genital infections. Sex Health 4(4):255–260

    Article  PubMed  Google Scholar 

  • Bala V, Jangir S, Kumar V, Mandalapu D, Gupta S, Kumar L, Kushwaha B, Chhonker YS, Krishna A, Maikhuri JP, Shukla PK (2014) Design and synthesis of substituted morpholin/piperidin-1-yl-carbamodithioates as promising vaginal microbicides with spermicidal potential. Bioorg Med Chem Lett 24(24):5782–5786

    Article  CAS  PubMed  Google Scholar 

  • Bala V, Jangir S, Mandalapu D, Gupta S, Chhonker YS, Lal N, Kushwaha B, Chandasana H, Krishna S, Rawat K, Maikhuri JP (2015a) Dithiocarbamate–thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: design, synthesis, docking and pharmacokinetic studies. Bioorg Med Chem Lett 25(4):881–886

    Article  CAS  PubMed  Google Scholar 

  • Bala V, Mandalapu D, Gupta S, Jangir S, Kushwaha B, Chhonker YS, Chandasana H, Krishna S, Rawat K, Krishna A, Singh M (2015b) N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl) piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition. Eur J Med Chem 101:640–650

    Article  CAS  PubMed  Google Scholar 

  • Bar AK, Phukan N, Pinheiro J, Simoes-Barbosa A (2015) The interplay of host microbiota and parasitic protozoans at mucosal interfaces: implications for the outcomes of infections and diseases. PLoS Negl Trop Dis 9(12):e0004176

    Article  PubMed  PubMed Central  Google Scholar 

  • Bébéar CM, Renaudin H, Schaeverbeke T, Leblanc F, Bébéar C (1999) In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas. J Antimicrob Chemother 43(5):711–714

    Article  PubMed  Google Scholar 

  • Bebear CM, Renaudin H, Bryskier A, Bebear C (2000) Comparative activities of telithromycin (HMR 3647), levofloxacin, and other antimicrobial agents against human mycoplasmas. Antimicrob Agents Chemother 44(7):1980–1982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bignell C, FitzGerald M, Guideline Development Group (2011) UK national guideline for the management of gonorrhoea in adults, 2011. Int J STD AIDS 22(10):541–547

    Article  CAS  PubMed  Google Scholar 

  • Borai NE, Inoue M, Lefèvre C, Naumova EN, Sato B, Yamamura M (1997) Detection of herpes simplex DNA in semen and menstrual blood of individuals attending an infertility clinic. J Obstet Gynaecol Res 23(1):17–24

    Article  PubMed  Google Scholar 

  • Bornman MS, Mahomed MF, Boomker D, Schulenburg GW, Reif S, Crewe-Brown HH (1990) Die mikrobielle Flora imSperma von kinderlosenafrikanischenMännernausdem Garankuwa-Hospital [Microbial flora in semen of infertile African men at Garankuwa hospital]. Andrologia 22(2):118–121

    Article  CAS  PubMed  Google Scholar 

  • Bouma MJ, Snowdon D, Fairlamb AH, Ackers JP (1998) Activity of disulfiram (bis (diethylthiocarbamoyl) disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and-resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother 42(6):817–820

    Article  CAS  PubMed  Google Scholar 

  • Brookings C, Goldmeier D, Sadeghi-Nejad H (2013) Sexually transmitted infections and sexual function in relation to male. Korean J Urol 54(3):149–156

    Article  PubMed  PubMed Central  Google Scholar 

  • Bujan L et al (2007) Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment. J Androl 28

    Google Scholar 

  • Cai LY et al (2009) HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells. Reprod Toxicol 27:14–21

    Article  CAS  PubMed  Google Scholar 

  • Cardona-Maya W, Lopez-Herrera A, Velilla-Hernandez P, Rugeles MT, Cadavid AP (2006) The role of mannose receptor on HIV-1 entry into human spermatozoa. Am J Reprod Immunol 55:241–245

    Article  CAS  PubMed  Google Scholar 

  • Carson SDB, Stone B, Beucher M, Fu J, Sparling PF (2000) Phase variation of the gonococcal siderophore receptor FetA. Mol Microbiol 36(3):585–593

    Article  CAS  PubMed  Google Scholar 

  • Ceballos A et al (2009) Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells. J Exp Med 206:2717–2733

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Centers for Disease Control (2015). https://www.cdc.gov/std/tg2015/

  • Centers for Disease Control and Prevention (2009) Sexually transmitted disease surveillance, 2008. US Department of Health and Human Services, Atlanta, GA, 2109755293(01111871), p 10148121180485

    Google Scholar 

  • Centers for Disease Control and Prevention (2011) Consultation meeting on cephalosporin-resistant gonorrhea outbreak response plan. 2009

    Google Scholar 

  • Colon-Lopez V, Ortiz AP, Palefsky J (2010) Burden of human papillomavirus infection and related comorbidities in men: implications for research, disease prevention and health promotion among Hispanic men. P R Health Sci J 29:232–240

    PubMed  PubMed Central  Google Scholar 

  • Cooke GS, Main J, Thursz MR (2010) Treatment for hepatitis B. BMJ 340:87–90

    Article  Google Scholar 

  • Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, Douglas JM Jr, Paavonen J, Morrow RA, Beutner KR, Stratchounsky LS (2004) Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 350(1):11–20

    Article  CAS  PubMed  Google Scholar 

  • Cosentino MJ, Cockett ATK (1986) Review article: structure and function of the epididymis. Urol Res 14(5):229–240

    Article  CAS  PubMed  Google Scholar 

  • Crowell AL, Stephens CE, Kumar A, Boykin DW, Secor WE (2004) Activities of dicationic compounds against Trichomonas vaginalis. Antimicrob Agents Chemother 48(9):3602–3605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • da Costa FAM, da Silva RC, Arruda LB, Montanheiro P, da Silva Duarte AJ, Casseb J (2010) Prevalence of Mycoplasma genitalium among HIV-infected men in Sao Paulo city detected by realtime polymerase chain reaction. Int J STD AIDS 21(1):23–25

    Article  PubMed  Google Scholar 

  • Danaher RJ, Levin JC, Arking D, Burch CL, Sandlin R, Stein DC (1995) Genetic basis of Neisseria gonorrhoeae lipooligosaccharide antigenic variation. J Bacteriol 177(24):7275–7279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Barbeyrac B et al (2006) Chlamydia trachomatis in subfertile couples undergoing an in vitro fertilization program: a prospective study. Eur J Obstet Gynecol Reprod Biol 129:46–53

    Article  PubMed  Google Scholar 

  • Deguchi T, Maeda SI (2002) Mycoplasma genitalium: another important pathogen of nongonococcal urethritis. J Urol 167(3):1210–1217

    Article  PubMed  Google Scholar 

  • Dehio C, Gray-Owen SD, Meyer TF (2000) Host cell invasion by pathogenic Neisseriae. Subcell Biochem 33:61–96

    Article  CAS  PubMed  Google Scholar 

  • DeTure FA, Drylie DM, Kaufman HE, Centifanto YN (1976) Herpesvirus type 2: isolation from seminal vesicle and testes. Urology 7(5):541–544

    Article  CAS  PubMed  Google Scholar 

  • Dondero, F, Rossi T, Offizi GD, Mazzilli F, Rosso R, Sarandrea N, Pinter E and Aiuti F (1996) Semen analysis in HIV seropositive men and in subjects at high risk for HIV infection. Hum Reprod. 11(4):765–8.

    Google Scholar 

  • Douek DC, Roederer M, Koup RA (2009) Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 60:471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dulioust E et al (2002) Semen alterations in HIV-1 infected men. Hum Reprod 17:2112–2118

    Article  CAS  PubMed  Google Scholar 

  • Dunne RL, Linda AD, Upcroft P, O’donoghue PJ, Upcroft JA (2003) Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis. Cell Res 13(4):239–249

    Article  CAS  PubMed  Google Scholar 

  • Durazzo M et al (2006) Alterations of seminal and hormonal parameters: an extrahepatic manifestation of HCV infection? World J Gastroenterol 12:3073–3076

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Edwards JL, Apicella MA (2004) The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. Clin Microbiol Rev 17:965–981

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • el Borai N et al (1997) Detection of herpes simplex DNA in semen and menstrual blood of individuals attending an infertility clinic. J Obstet Gynaecol Res 23:17–24

    Article  PubMed  Google Scholar 

  • Eley A, Pacey AA, Galdiero M, Galdiero M, Galdiero F (2005) Can Chlamydia trachomatis directly damage your sperm? Lancet Infect Dis 5:53–57

    Article  PubMed  Google Scholar 

  • Fair WR, Couch J, Wehner N (1976) Prostatic antibacterial factor identity and significance. Urology 7(2):169–177

    Article  CAS  PubMed  Google Scholar 

  • Ficarra G, Carlos R (2009) Syphilis: the renaissance of an old disease with oral implications. Head Neck Pathol 3(3):195–206

    Article  PubMed  PubMed Central  Google Scholar 

  • Foresta C et al (2010) Clinical and prognostic significance of human papillomavirus DNA in the sperm or exfoliated cells of infertile patients and subjects with risk factors. Fertil Steril 94:1723–1727

    Article  CAS  PubMed  Google Scholar 

  • Foresta C, Patassini C, Bertoldo A, Menegazzo M, Francavilla F, Barzon L, Ferlin A (2011) Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa. PLoS One 6(3):e15036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, Häussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347(13):975–982

    Article  CAS  PubMed  Google Scholar 

  • Fung HB, Doan TL (2005) Tinidazole: a nitroimidazole antiprotozoal agent. Clin Ther 27(12):1859–1884

    Article  CAS  PubMed  Google Scholar 

  • Furuya R, Takahashi S, Furuya S, Kunishima Y, Takeyama KOH, Tsukamoto T (2004) Is seminal vesiculitis a discrete disease entity? Clinical and microbiological study of seminal vesiculitis in patients with acute epididymitis. J Urol 171(4):1550–1553

    Article  PubMed  Google Scholar 

  • Gambini D, Decleva I, Lupica L, Ghislanzoni M, Cusini M, Alessi E (2000) Mycoplasma genitaliumin males with nongonococcal urethritis: prevalence and clinical efficacy of eradication. Sex Transm Dis 27(4):226–229

    Article  CAS  PubMed  Google Scholar 

  • Garolla A et al (2012) Human papillomavirus sperm infection and assisted reproduction: a dangerous hazard with a possible safe solution. Hum Reprod 27:967–973

    Article  CAS  PubMed  Google Scholar 

  • Gdoura R et al (2008) Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples. J Androl 29:198–206

    Article  CAS  PubMed  Google Scholar 

  • Geder L, Sanford EJ, Rohner TJ, Rapp F (1976) Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells. Cancer Treat Rep 61(2):139–146

    Google Scholar 

  • Geisler WM (2010) Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies. J Infect Dis 201(Suppl. 2):S104–S113

    Article  PubMed  Google Scholar 

  • Gimenes F, Souza RP, Bento JC, Teixeira JJ, Maria-Engler SS, Bonini MG, Consolaro ME (2014) Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol 11(12):672–687

    Article  PubMed  Google Scholar 

  • Gopalkrishnan K, Hinduja IN, Kumar TA (1990) Semen characteristics of asymptomatic males affected by Trichomonas vaginalis. J In Vitro Fert Embryo Transf 7(3):165–167

    Article  CAS  PubMed  Google Scholar 

  • Griffiths PD (2002) The treatment of cytomegalovirus infection. J Antimicrob Chemother 49(2):243–253

    Article  CAS  PubMed  Google Scholar 

  • Guenthner PC, Secor WE, Dezzutti CS (2005) Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1. Infect Immun 73(7):4155–4160

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gupta R, Warren T, Wald A (2008) Genital herpes. Lancet 370(9605):2127–2137

    Article  Google Scholar 

  • Hadchouel M et al (1985) Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line. J Med Virol 16:61–66

    Article  CAS  PubMed  Google Scholar 

  • Hadziyannis SJ, Sette H, Morgan TR, Balan V, Diago M, Marcellin P, Ramadori G, Bodenheimer H, Bernstein D, Rizzetto M, Zeuzem S (2004) Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 140(5):346–355

    Article  CAS  PubMed  Google Scholar 

  • Hannan PC, Woodnutt G (2000) In vitro activity of gemifloxacin (SB 265805; LB20304a) against human mycoplasmas. J Antimicrob Chemother 45(3):367–369

    Article  CAS  PubMed  Google Scholar 

  • Harkness AH (1948) The pathology of gonorrhoea. Br J Vener Dis 24(4):137

    CAS  PubMed  PubMed Central  Google Scholar 

  • Harp DF, Chowdhury I (2011) Trichomoniasis: evaluation to execution. Eur J Obstet Gynecol Reprod Biol 157(1):3–9

    Article  PubMed  PubMed Central  Google Scholar 

  • Henkel R et al (2006) Chronic pelvic pain syndrome/chronic prostatitis affect the acrosome reaction in human spermatozoa. World J Urol 24:39–44

    Article  PubMed  Google Scholar 

  • Hofny ERM, Ali MEM, Taha EA, Nafeh HM, Sayed DS, Abdel-Azeem HG, Abdou EF, Kamal GM, Mostafa T (2011) Semen and hormonal parameters in men with chronic hepatitis C infection. Fertil Steril 95(8):2557–2559

    Article  CAS  PubMed  Google Scholar 

  • Hosseinzadeh S, Brewis IA, Eley A, Pacey AA (2001) Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Hum Reprod 16:293–299

    Article  CAS  PubMed  Google Scholar 

  • Hosseinzadeh S, Pacey AA, Eley A (2003) Chlamydia trachomatis-induced death of human spermatozoa is caused primarily by lipopolysaccharide. J Med Microbiol 52:193–200

    Article  CAS  PubMed  Google Scholar 

  • Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Qiu JW (2002) Studies on the integration of hepatitis B virus DNA sequence in human sperm chromosomes. Asian J Androl 4(3):209–212

    CAS  PubMed  Google Scholar 

  • Huttner KM, Pudney J, Milstone DS, Ladd D, Seidman JG (1993) Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse. Biol Reprod 49:251–261

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim AA, Refeidi A, El Mekki AA (1996) Etiology and clinical features of acute epididymo-orchitis. Ann Saudi Med 16:171–174

    Article  CAS  PubMed  Google Scholar 

  • Idahl A, Boman J, Kumlin U, Olofsson JI (2004) Demonstration of Chlamydia trachomatis IgG antibodies in the male partner of the infertile couple is correlated with a reduced likelihood of achieving pregnancy. Hum Reprod 19:1121–1126

    Article  CAS  PubMed  Google Scholar 

  • Isaiah IN, Nche BT, Nwagu IG, Nnanna II (2011) Current studies on bacterospermia the leading cause of male infertility: a protégé and potential threat towards mans extinction. N Am J Med Sci 3(12):562

    PubMed  PubMed Central  Google Scholar 

  • Jain A, Lal N, Kumar L, Verma V, Kumar R, Kumar L, Singh V, Mishra RK, Sarswat A, Jain SK, Maikhuri JP (2011) Novel trichomonacidal spermicides. Antimicrob Agents Chemother 55(9):4343–4351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jain A, Kumar L, Kushwaha B, Sharma M, Pandey A, Verma V, Sharma V, Singh V, Rawat T, Sharma VL, Maikhuri JP (2014) Combining a synthetic spermicide with a natural trichomonacide for safe, prophylactic contraception. Hum Reprod 29(2):242–252

    Article  CAS  PubMed  Google Scholar 

  • Jarecki-Black JC, Lushbaugh WB, Golosov L, Glassman AB (1988) Trichomonas vaginalis: preliminary characterization of a sperm motility inhibiting factor. Ann Clin Lab Sci 18(6):484–489

    CAS  PubMed  Google Scholar 

  • Jensen JS (2004) Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases. J Eur Acad Dermatol Venereol 18:1–11

    Article  PubMed  Google Scholar 

  • Johannisson G, Enström Y, Löwhagen GB, Nagy V, Ryberg K, Seeberg S, Welinder-Olsson C (2000) Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int J STD AIDS 11(5):324–326

    Article  CAS  PubMed  Google Scholar 

  • Joki-Korpela P et al (2009) The role of Chlamydia trachomatis infection in male infertility. Fertil Steril 91:1448–1450

    Article  PubMed  Google Scholar 

  • Kaneda Y, Torii M, Tanaka T, Aikawa M (1991) In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 85(4):417–425

    Article  CAS  PubMed  Google Scholar 

  • Kang X, Xie Q, Zhou X, Li F, Huang J, Liu D, Huang T (2012) Effects of hepatitis B virus S protein exposure on sperm membrane integrity and functions. PLoS One 7(3):e33471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kapranos N, Petrakou E, Anastasiadou C, Kotronias D (2003) Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic. Fertil Steril 79:1566–1570

    Article  PubMed  Google Scholar 

  • Karinen L et al (2004) Association between Chlamydia trachomatis antibodies and subfertility in the Northern Finland Birth Cohort 1966 (NFBC 1966), at the age of 31 years. Epidemiol Infect 132:977–984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaspersen MD, Hollsberg P (2013) Seminal shedding of human herpesviruses. Virol J 10:226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katiyar SK, Gordon VR, McLaughlin GL, Edlind TD (1994) Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence. Antimicrob Agents Chemother 38(9):2086–2090

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katz AR, Lee MV, Wasserman GM (2012) Sexually transmitted disease (STD) update: a review of the CDC 2010 STD treatment guidelines and epidemiologic trends of common STDs in Hawai’i. Hawaii J Med Public Health 71(3):68–73

    PubMed  PubMed Central  Google Scholar 

  • Kent ME, Romanelli F (2008) Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Ann Pharmacother 42(2):226–236

    Article  CAS  PubMed  Google Scholar 

  • Khan N (2007) The immunological burden of human cytomegalovirus infection. Arch Immunol Ther Exp 55(5):299–308

    Article  CAS  Google Scholar 

  • Kimura M, Maekura S, Satou T, Hashimoto S (1993a) Cytomegaloviral inclusions detected in the seminal vesicle, ductus deferens and lungs in an autopsy case of lung cancer [Japanese]. Rinsho Byori 41:1059–1062

    CAS  PubMed  Google Scholar 

  • Kimura M, Maekura S, Satou T, Hashimoto S (1993b) [Cytomegaloviral inclusions detected in the seminal vesicle, ductus deferens and lungs in an autopsy case of lung cancer]. Rinsho Byori 41(9):1059–1062

    Google Scholar 

  • Klimova RR et al (2010) Herpes simplex virus and cytomegalovirus in male ejaculate: herpes simplex virus is more frequently encountered in idiopathic infertility and correlates with the reduction in sperm parameters [Russian]. Vopr Virusol 55:27–31

    CAS  PubMed  Google Scholar 

  • Korzeniewski K, Juszczak D (2015) Travel-related sexually transmitted infections. Int Marit Health 66(4):238–246

    Article  PubMed  Google Scholar 

  • Krieger JN, Nyberg L Jr, Nickel JC (1999) NIH consensus definition and classification of prostatitis. JAMA 282(3):236–237

    Article  CAS  PubMed  Google Scholar 

  • Krishnan R, Heal MR (1991) Study of the seminal vesicles in acute epididymitis. Br J Urol 67(6):632–637

    Article  CAS  PubMed  Google Scholar 

  • Kumar L, Lal N, Kumar V, Sarswat A, Jangir S, Bala V, Kumar L, Kushwaha B, Pandey AK, Siddiqi MI, Shukla PK (2013) Azole–carbodithioate hybrids as vaginal anti-Candida contraceptive agents: design, synthesis and docking studies. Eur J Med Chem 70:68–77

    Article  CAS  PubMed  Google Scholar 

  • Kushwaha B, Mandalapu D, Bala V, Kumar L, Pandey A, Pandey D, Yadav SK, Singh P, Shukla PK, Maikhuri JP, Sankhwar SN (2016) Ammonium salts of carbamodithioic acid as potent vaginal trichomonacides and fungicides. Int J Antimicrob Agents 47(1):36–47

    Article  CAS  PubMed  Google Scholar 

  • Kyo S et al (1994) Detection of high-risk human papillomavirus in the cervix and semen of sex partners. J Infect Dis 170:682–685

    Article  CAS  PubMed  Google Scholar 

  • La Vignera S, Vicari E, Condorelli RA, d’Agata R, Calogero AE (2011) Male accessory gland infection and sperm parameters (review). Int J Androl 34(5 Pt 2):e330–e347

    Article  PubMed  Google Scholar 

  • La Vignera S, Condorelli RA, Vicari E, D’Agata R, Calogero AE (2012) Sperm DNA damage in patients with chronic viral C hepatitis. Eur J Intern Med 23:e19–e24

    Article  CAS  PubMed  Google Scholar 

  • Lai YM et al (1997) The effect of human papillomavirus infection on sperm cell motility. Fertil Steril 67:1152–1155

    Article  CAS  PubMed  Google Scholar 

  • LaMontagne DS, Fenton KA, Randall S, Anderson S, Carter P (2004) Establishing the National Chlamydia Screening Programme in England: results from the first full year of screening. Sex Transm Infect 80:335–341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lang DJ, Kummer JF, Hartley DP (1974) Cytomegalovirus in semen. Persistence and demonstration in extracellular fluids. N Engl J Med 291:121–123

    Article  CAS  PubMed  Google Scholar 

  • Laprise C, Trottier H, Monnier P, Coutlee F, Mayrand MH (2014) Prevalence of human papillomaviruses in semen: a systematic review and meta-analysis. Hum Reprod 29:640–651

    Article  PubMed  Google Scholar 

  • Lederman MM, Offord RE, Hartley O (2006) Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol 6:371–382

    Article  CAS  PubMed  Google Scholar 

  • Lemoine M, Nayagam S, Thursz M (2013) Viral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges. Futur Virol 8(4):371–380

    Article  CAS  Google Scholar 

  • Lepor H, Wang B, Shapiro E (1994) Relationship between prostatic epithelial volume and serum prostate-specific antigen levels. Urology 44(2):199–205

    Article  CAS  PubMed  Google Scholar 

  • Levy R et al (1997) Detection of cytomegalovirus in semen from a population of men seeking infertility evaluation. Fertil Steril 68:820–825

    Article  CAS  PubMed  Google Scholar 

  • Ljungman P, Griffiths P, Paya C (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34(8):1094–1097

    Article  PubMed  Google Scholar 

  • Lo JY, Ho KM, Leung AO, Tiu FS, Tsang GK, Lo AC, Tapsall JW (2008) Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. Antimicrob Agents Chemother 52(10):3564–3567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lorusso F et al (2010) Impact of chronic viral diseases on semen parameters. Andrologia 42:121–126

    Article  CAS  PubMed  Google Scholar 

  • Lossick JG (1990) Epidemiology of urogenital trichomoniasis. In: Trichomonads parasitic in humans. Springer, New York, pp 311–323

    Chapter  Google Scholar 

  • Maan MA, Fatma H, Muhammad J (2014) Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010–2012). Afr Health Sci 14(4):810–814

    Article  PubMed  PubMed Central  Google Scholar 

  • Maartens G, Celum C, Lewin SR (2014) HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet 384(9939):258–271

    Article  PubMed  Google Scholar 

  • Macickova T, Kettner M, Linek K (1990) In vivo effect of 2, 4-dinitro-phenyl-substituted sugar hydrazones and phenylosazone against Trichomonas vaginalis and Tritrichomonas foetus. Pharmazie 45(3):204–206

    CAS  PubMed  Google Scholar 

  • Maeda S et al (2004) Detection of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum (biovar 1) and Ureaplasma urealyticum (biovar 2) in patients with non-gonococcal urethritis using polymerase chain reaction-microtiter plate hybridization. Int J Urol 11:750–754

    Article  PubMed  Google Scholar 

  • Malagoli M, Rossi T, Baggio A, Zandomeneghi G, Zanca A, Casolari C, Castelli M (2002) In vitro study of chemotherapeutic activity of sulphimidazole on some sensitive and metronidazole resistant-Trichomonas vaginalis strains. Pharmacol Res 46(5):469–472

    Article  CAS  PubMed  Google Scholar 

  • Mandalapu D, Lal N, Kumar L, Kushwaha B, Gupta S, Kumar L, Bala V, Yadav SK, Singh P, Singh N, Maikhuri JP (2015) Innovative disulfide esters of dithiocarbamic acid as women-controlled contraceptive microbicides: a bioisosterism approach. ChemMedChem 10(10):1739–1753

    Article  CAS  PubMed  Google Scholar 

  • Manhart LE, Broad JM, Golden MR (2011) Mycoplasma genitalium: should we treat and how? Clin Infect Dis 53(Suppl. 3):S129–S142

    Article  PubMed  PubMed Central  Google Scholar 

  • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling MH, Albrecht JK, Group, I.H.I.T (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358(9286):958–965

    Article  CAS  PubMed  Google Scholar 

  • Marconi M, Pilatz A, Wagenlehner F, Diemer T, Weidner W (2009) Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 35(3):299–309

    Article  CAS  PubMed  Google Scholar 

  • Martínez-Prado E, CamejoBermúdez MI (2010) Expression of IL-6, IL-8, TNF-α, IL-10, HSP-60, anti-HSP-60 antibodies, and anti-sperm antibodies, in semen of men with leukocytes and/or bacteria. Am J Reprod Immunol 63(3):233–243

    Article  PubMed  CAS  Google Scholar 

  • Mastroianni A, Coronado O, Manfredi R, Chiodo F, Scarani P (1996) Acute cytomegalovirus prostatitis in AIDS. Genitourin Med 72

    Google Scholar 

  • Mazzoli S, Cai T, Addonisio P, Bechi A, Mondaini N, Bartoletti R (2010) Chlamydia trachomatis infection is related to poor semen quality in young prostatitis patients. Eur Urol 57(4):708–714

    Article  PubMed  Google Scholar 

  • Mielczarek E, Blaszkowska J (2015) Trichomonas vaginalis: pathogenicity and potential role in human reproductive failure. Infection:1–12

    Google Scholar 

  • Mlynarczyk-Bonikowska B, Majewska A, Malejczyk M, Mlynarczyk G, Majewski S (2013) Antiviral medication in sexually transmitted diseases. Part I: HSV, HPV. Mini Rev Med Chem 13(13):1837–1845

    Article  CAS  PubMed  Google Scholar 

  • Modi AA, Liang TJ (2008) Hepatitis C: a clinical review. Oral Dis 14(1):10–14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Monavari SH, Vaziri MS, Khalili M, Shamsi-Shahrabadi M, Keyvani H, Mollaei H, Fazlalipour M (2013) Asymptomatic seminal infection of herpes simplex virus: impact on male infertility. J Biomed Res 27(1):56–61

    PubMed  Google Scholar 

  • Montagut JM, Lepretre S, Degoy J, Rousseau M (1991) Ureaplasma in semen and IVF. Hum Reprod 6:727–729

    Article  CAS  PubMed  Google Scholar 

  • Motrich RD, Maccioni M, Molina R, Tissera A, Olmedo J, Riera CM, Rivero VE (2005) Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens. Hum Reprod 20(9):2567–2572

    Article  PubMed  Google Scholar 

  • Motrich RD, Cuffini C, Oberti JP, Maccioni M, Rivero VE (2006) Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients. J Infect 53:175–183

    Article  PubMed  Google Scholar 

  • Muciaccia B et al (1998) Testicular germ cells of HIV-seropositive asymptomatic men are infected by the virus. J Reprod Immunol 41:81–93

    Article  CAS  PubMed  Google Scholar 

  • Muciaccia B, Corallini S, Vicini E, Padula F, Gandini L, Liuzzi G, Lenzi A, Stefanini M (2007) HIV-1 viral DNA is present in ejaculated abnormal spermatozoa of seropositive subjects. Hum Reprod 22(11):2868–2878

    Article  CAS  PubMed  Google Scholar 

  • Naumenko VA et al (2011) Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture. Herpesviridae 2:7

    Article  PubMed  PubMed Central  Google Scholar 

  • Neofytou E, Sourvinos G, Asmarianaki M, Spandidos DA, Makrigiannakis A (2009) Prevalence of human herpes virus types 1–7 in the semen of men attending an infertility clinic and correlation with semen parameters. Fertil Steril 91

    Google Scholar 

  • Ness RB, Markovic N, Carlson CL, Coughlin MT (1997) Do men become infertile after having sexually transmitted urethritis? An epidemiologic examination. Fertil Steril 68(2):205–213

    Article  CAS  PubMed  Google Scholar 

  • Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N, Stevens G, Gottlieb S, Kiarie J, Temmerman M (2015) Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One 10(12):e0143304

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nuovo GJ et al (1994) HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization. Am J Pathol 144:1142–1148

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ochsendorf FR (2008) Sexually transmitted infections: impact on male fertility. Andrologia 40(2):72–75

    Article  CAS  PubMed  Google Scholar 

  • Ohnishi M, Saika T, Hoshina S, Iwasaku K, Nakayama SI, Watanabe H, Kitawaki J (2011) Ceftriaxone-resistant Neisseria gonorrhoeae, Japan. Emerg Infect Dis 17(1):148–150

    Article  PubMed  PubMed Central  Google Scholar 

  • Okamura N, Tajima Y, Ishikawa H, Yoshii S, Koiso K, Sugita Y (1986) Lowered levels of bicarbonate in seminal plasma cause the poor sperm motility in human infertile patients. Fertil Steril 45(2):265–272

    Article  CAS  PubMed  Google Scholar 

  • Ouzounova-Raykova V, Ouzounova I, Mitov IG (2010) May Chlamydia trachomatis be an aetiological agent of chronic prostatic infection? Andrologia 42:176–181

    Article  CAS  PubMed  Google Scholar 

  • Pajovic B, Radojevic N, Vukovic M, Stjepcevic A (2013) Semen analysis before and after antibiotic treatment of asymptomatic Chlamydia-and Ureaplasma-related pyospermia. Andrologia 45:266–271

    Article  CAS  PubMed  Google Scholar 

  • Patel R, Rompalo A (2005) Managing patients with genital herpes and their sexual partners. Infect Dis Clin N Am 19(2):427–438

    Article  Google Scholar 

  • Pellati D et al (2008) Genital tract infections and infertility. Eur J Obstet Gynecol Reprod Biol 140:3–11

    Article  PubMed  Google Scholar 

  • Perez-Andino J, Buck CB, Ribbeck K (2009) Adsorption of human papillomavirus 16 to live human sperm. PLoS One 4(6):e5847

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Perino A et al (2011) Human papillomavirus infection in couples undergoing in vitro fertilization procedures: impact on reproductive outcomes. Fertil Steril 95:1845–1848

    Article  PubMed  Google Scholar 

  • Reichart M, Kahane I, Bartoov B (2000) In vivo and in vitro impairment of human and ram sperm nuclear chromatin integrity by sexually transmitted Ureaplasma urealyticum infection. Biol Reprod 63:1041–1048

    Article  CAS  PubMed  Google Scholar 

  • Reichart M, Levi H, Kahane I, Bartoov B (2001) Dual energy metabolism-dependent effect of Ureaplasma urealyticum infection on sperm activity. J Androl 22:404–412

    CAS  PubMed  Google Scholar 

  • Renaudin H, Tully JG, Bebear C (1992) In vitro susceptibilities of Mycoplasma genitalium to antibiotics. Antimicrob Agents Chemother 36(4):870–872

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rosen HR (2011) Chronic hepatitis C infection. N Engl J Med 364(25):2429–2438

    Article  CAS  PubMed  Google Scholar 

  • Ryan KJ, Ray CG (2004) Medical microbiology: an introduction to infectious diseases. Mcgraw-Hill

    Google Scholar 

  • Rybar R, Prinosilova P, Kopecka V, Hlavicova J, Veznik Z, Zajicova A, Rubes J (2012) The effect of bacterial contamination of semen on sperm chromatin integrity and standard semen parameters in men from infertile couples. Andrologia 44(s1):410–418

    Article  PubMed  Google Scholar 

  • Satta A et al (2006) Experimental Chlamydia trachomatis infection causes apoptosis in human sperm. Hum Reprod 21:134–137

    Article  PubMed  Google Scholar 

  • Schneede P, Tenke P, Hofstetter AG (2003) Sexually transmitted diseases (STDs)—a synoptic overview for urologists. Eur Urol 44(1):1–7

    Article  PubMed  Google Scholar 

  • Schneider H, Hammack CA, Apicella MA, Griffiss JM (1988) Instability of expression of lipooligosaccharides and their epitopes in Neisseria gonorrhoeae. Infect Immun 56(4):942–946

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sethi S, Singh G, Samanta P, Sharma M (2012) Mycoplasma genitalium: an emerging sexually transmitted pathogen. Indian J Med Res 136(6):942

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shang XJ et al (1999) Ureaplasma urealyticum infection and apoptosis of spermatogenic cells. Asian J Androl 1:127–129

    CAS  PubMed  Google Scholar 

  • Shehu-Xhilaga M et al (2007) The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection. Retrovirology 4:7

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sheikh SH, Waqqar S, William GP, Aziz S, Bano S, David A, Ahsan M (2014) Herpes simplex & cytomegaloviruses inflicted semen substantiates infertility among men. J Dent Med Sci:74–77

    Google Scholar 

  • Shevchuk MM, Nuovo GJ, Khalife G (1998) HIV in testis: quantitative histology and HIV localization in germ cells. J Reprod Immunol 41:69–79

    Article  CAS  PubMed  Google Scholar 

  • Shouval D (2003) Hepatitis B vaccines. J Hepatol 39:70–76

    Article  CAS  Google Scholar 

  • Soni S et al (2010) The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex Transm Infect 86:21–24

    Article  CAS  PubMed  Google Scholar 

  • Soper D (2004) Trichomoniasis: under control or undercontrolled? Am J Obstet Gynecol 190(1):281–290

    Article  PubMed  Google Scholar 

  • Svenstrup HF, Fedder J, Abraham-Peskir J, Birkelund S, Christiansen G (2003) Mycoplasma genitalium attaches to human spermatozoa. Hum Reprod 18:2103–2109

    Article  PubMed  Google Scholar 

  • Taylor BD, Haggerty CL (2011) Management of Chlamydia trachomatis genital tract infection: screening and treatment challenges. Infect Drug Resist 4:19–29

    Article  PubMed  PubMed Central  Google Scholar 

  • Taylor-Robinson D, Bebear C (1997) Antibiotic susceptibilities of mycoplasmas and treatment of mycoplasmal infections. J Antimicrob Chemother 40(5):622–630

    Article  CAS  PubMed  Google Scholar 

  • Toy M, Veldhuijzen IK, Mostert MC, De Man RA, Richardus JH (2008) Transmission routes of hepatitis B virus infection in chronic hepatitis B patients in the Netherlands. J Med Virol 80(3):399–404

    Article  CAS  PubMed  Google Scholar 

  • Trojian TH, Lishnak TS, Heiman D (2009) Epididymitis and orchitis: an overview. Am Fam Physician 79:583–587

    PubMed  Google Scholar 

  • Tuttle JP Jr, Holbrook TW, Derrick FC (1977) Interference of human spermatozoal motility by Trichomonas vaginalis. J Urol 118(6):1024–1025

    PubMed  Google Scholar 

  • Twu O, Dessí D, Vu A, Mercer F, Stevens GC, De Miguel N, Rappelli P, Cocco AR, Clubb RT, Fiori PL, Johnson PJ (2014) Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses. Proc Natl Acad Sci 111(22):8179–8184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uuskula A, Kohl PK (2002) Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents. Int J STD AIDS 13:79–85

    Article  PubMed  Google Scholar 

  • van Leeuwen E et al (2008) Effects of antiretroviral therapy on semen quality. AIDS 22:637–642

    Article  PubMed  Google Scholar 

  • Van Vranken M (2007) Prevention and treatment of sexually transmitted diseases: an update. Am Fam Physician 76(12)

    Google Scholar 

  • Varani S, Landini MP (2011) Cytomegalovirus-induced immunopathology and its clinical consequences. Herpesviridae 2(1):1

    Article  CAS  Google Scholar 

  • Veznik Z, Pospisil L, Svecova D, Zajicova A, Unzeitig V (2004) Chlamydiae in the ejaculate: their influence on the quality and morphology of sperm. Acta Obstet Gynecol Scand 83:656–660

    Article  PubMed  Google Scholar 

  • Vicari E et al (2006) Sperm output in patients with primary infertility and hepatitis B or C virus; negative influence of HBV infection during concomitant varicocele. Minerva Med 97:65–77

    CAS  PubMed  Google Scholar 

  • Wang SA, Lee MVC, O'Connor N, Iverson CJ, Ohye RG, Whiticar PM, Hale JA, Trees DL, Knapp JS, Effler PV, Weinstock HS (2003) Multidrug-resistant Neisseria gonorrhoeae with decreased susceptibility to cefixime—Hawaii, 2001. Clin Infect Dis 37(6):849–852

    Article  CAS  PubMed  Google Scholar 

  • Weidner W, Krause W, Ludwig M (1999) Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 5(5):421–432

    Article  CAS  PubMed  Google Scholar 

  • Weiss RA (1993) How does HIV cause AIDS? Science 260(5112):1273–1279

    Article  CAS  PubMed  Google Scholar 

  • Workowski KA, Berman SM (2007) Centers for disease control and prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis 44(Suppl 3):S73–S76

    Article  PubMed  Google Scholar 

  • Workowski KA, Berman SM, Centers for Disease Control and Prevention (2006) Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 55(RR-11):1–94

    PubMed  Google Scholar 

  • World Health Organization (2016) Fact sheets, sexually transmitted infections (STIs). http://www.who.int/mediacentre/factsheets/fs110/en/

  • Wu KH et al (2007) Infection of cytomegalovirus and herpes simplex virus and morphology of the infected spermatogenic cells in infertile men [Chinese]. Zhonghua Nan Ke Xue 13

    Google Scholar 

  • Xu X (1992) The possible role of sperm in family HBV infection [Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi 13:337–339

    CAS  PubMed  Google Scholar 

  • Xu C, Sun GF, Zhu YF, Wang YF (1997) The correlation of Ureaplasma urealyticum infection with infertility. Andrologia 29(4):219–226

    Article  CAS  PubMed  Google Scholar 

  • Yang Y, Jia CW, Ma YM, Zhou LY, Wang SY (2013) Correlation between HPV sperm infection and male infertility. Asian J Androl 15(4):529–532

    Article  PubMed  PubMed Central  Google Scholar 

  • Yokoi S, Deguchi T, Ozawa T, Yasuda M, Ito SI, Kubota Y, Tamaki M, Maeda SI (2007) Threat to cefixime treatment for gonorrhea. Emerg Infect Dis 13(8):1275–1277

    PubMed  PubMed Central  Google Scholar 

  • Zaneveld LJ, Waller DP, Anderson RA, Chany C 2nd, Rencher WF, Feathergill K, Diao XH, Doncel GF, Herold B, Cooper M (2002) Efficacy and safety of a new vaginal contraceptive antimicrobial formulation containing high molecular weight poly(sodium 4-styrenesulfonate). Biol Reprod 66(4):886–894

    Article  CAS  PubMed  Google Scholar 

  • Zeighami H, Peerayeh SN, Yazdi RS, Sorouri R (2009) Prevalence of Ureaplasma urealyticum and Ureaplasma parvum in semen of infertile and healthy men. Int J STD AIDS 20:387–390

    Article  CAS  PubMed  Google Scholar 

  • Zhou XP et al (2011) Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B. Asian J Androl 13:465–469

    Article  PubMed  PubMed Central  Google Scholar 

  • Zinzendorf NY, Kouassi-Agbessi BT, Lathro JS, Don C, Kouadio L (2008) Ureaplasma urealyticum or Mycoplasma hominis infections and semen quality of infertile men in Abidjan. Journal of Reproduction and Contraception. 19(2):65–72.

    Google Scholar 

  • Ziomko I, KuczyÅ„ska E (1993) [Trichomonacidal activity of newly synthesized derivatives of benzoizothiazolinon (BIT) in vitro]. Wiad Parazytol 40(1):59–64

    Google Scholar 

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  1. Male Reproductive Biology Laboratory, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

    Bhavana Kushwaha & Gopal Gupta

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  1. Endocrinology Division, Central Drug Research Institute, Lucknow, Uttar Pradesh, India

    RAJENDER SINGH

  2. Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Kiran Singh

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Kushwaha, B., Gupta, G. (2017). Sexually Transmitted Infections and Male Infertility: Old Enigma, New Insights. In: SINGH, R., Singh, K. (eds) Male Infertility: Understanding, Causes and Treatment. Springer, Singapore. https://doi.org/10.1007/978-981-10-4017-7_12

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