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The Prostate Gland

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Basics of Human Andrology

Abstract

  • Development and gross anatomical features

  • Lobes and zones

  • Microstructure and functional regulation

  • Components of prostatic fluid

  • Disorders of prostate gland

The name ‘prostate’ is originally derived from a Greek word ‘prohistani’ (means ‘to stand in front of’). The prostate is the largest accessory sex gland of males. It is a musculo-glandular, exocrine gland that secretes alkaline fluid which constitutes about 20–30 % volume of the seminal fluid. Changes in the prostatic fluid composition and/or secretion affect sperm functions and may lead to male infertility. The gland is often associated with disorders of elderly, benign prostatic hyperplasia (BPH) and carcinoma.

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References

  • Abrahamsson PA, di Sant'Agnese PA. Neuroendocrine cells in the human prostate gland: Minireview. J Androl. 1993;14:307–9.

    CAS  PubMed  Google Scholar 

  • Assinder SJ. Oxytocin increases 5a-reductase activity of human prostate epithelial cells, but not stromal cells. Prostate. 2008;68(2):115–21.

    Article  CAS  PubMed  Google Scholar 

  • Azzouni F, Godoy A, Li Y, Mohler J. The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Adv Urol. 2012;79:1197–205.

    Article  Google Scholar 

  • Balk SP, Ko YJ, Bubley GJ. Biology of prostate-specific antigen. J Clin Oncol. 2003;21:383–91.

    Article  CAS  PubMed  Google Scholar 

  • Briganti A, Capitanio U, Suardi N, Gallina A, Salonia A, Bianchi M, et al. Benign prostatic hyperplasia and its aetiologies. Eur Urol Suppl. 2009;8:865–71.

    Article  Google Scholar 

  • Buijs JT, Rentsch CA, van der Horst G, Overveld PG, Wetterwald A, Schwaninger R, et al. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am J Pathol. 2007;171(3):1047–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cockburn M, Mills P, Zhang X, Zadnick J, Goldberg D, et al. Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California. Am J Epidemiol. 2011;173(11):1280–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Costello LC, Franklin RB. Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem. Prostate Cancer Prostatic Dis. 2009;12(1):17–24.

    Article  CAS  PubMed  Google Scholar 

  • Costello LC, Franklin RB. Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Horm Metab Res. 2002;34(8):417–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Krester DM, Temple-Smith PD, Kerr JB. Anatomical and functional aspects of male reproductive organs, ch 7-Prostate. In: Bandhauer K, Fricj J, editors. Disturbances in male infertility. Berlin/Heidelberg/New York: Springer; 1982. p. 98–114.

    Google Scholar 

  • Decker GAG, du Plessis DJ. The large bowel, anal canal and ischiorectal fossa. In: Le Mcgregor’s synopsis of surgical anatomy, 12th ed. Indian Edition, Bombay: Varghese publishing house. 1986. p. 41–78.

    Google Scholar 

  • Diamandis EP. Prostate-specific antigen: a cancer fighter and a valuable messenger? Clin Chem. 2000;46:896–900.

    CAS  PubMed  Google Scholar 

  • Dich J, Wiklund K. Prostate cancer in pesticide applicators in Swedish agriculture. Prostate. 1998;34(2):100–12.

    Article  CAS  PubMed  Google Scholar 

  • Ellem SJ, Risbridger GP. The dual, opposing roles of estrogen in the prostate. Ann N Y Acad Sci. 2009;1155:174–86.

    Article  CAS  PubMed  Google Scholar 

  • Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001;1:34–45.

    Article  CAS  PubMed  Google Scholar 

  • Folk JE, Park MH, Chung SI, Schrode J, Lester EP, Cooper HL. Polyamines as physiological substrates for transglutaminases. J Biol Chem. 1980;255:3695–700.

    CAS  PubMed  Google Scholar 

  • Franklin RB, Milon B, Feng P, Costello LC. Zinc and zinc transporters in normal prostate function and the pathogenesis of prostate cancer. Front Biosci. 2005;10:2230–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garde SV, Sheth AR, Lohiya NK, Shah MG. Prostatic inhibin peptide: occurrence, localization and its hormonal modulation in prostates of primates and rodents. J Biosci. 1992;17(1):67–85.

    Article  CAS  Google Scholar 

  • Goffin V, Hoang DT, Bogorad RL, Nevalainen MT. Prolactin regulation of the prostate gland: a female player in a male game. Nat Rev Urol. 2011;8:597–607.

    Article  CAS  PubMed  Google Scholar 

  • Grayhack JT, Kozlowski JM. Benign Prostatic Hyperplasia. In: Gillenwater JY, Grayhack JT, Howards SS, Duckett JW, editors. Adult and Pediatrics Urology, 3rd ed. vol. 2; C.V.Mosby, St.Louis.1996. p. 1501–74.

    Google Scholar 

  • Haiman CA, Stram DO, Vickers AJ, Wilkens LR, Braun K, Valtonen-Andre C, et al. Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations. J Natl Cancer Inst. 2013;105(3):237–43.

    Article  CAS  PubMed  Google Scholar 

  • Hammerich KH, Ayala GE, Wheeler TM. Anatomy of the prostate gland and surgical pathology of prostate cancer. In: Hricak H, Scardino PT, editors. Prostate cancer. Cambridge/New York: Cambridge University Press; 2009. p. 1–14.

    Google Scholar 

  • Harkonen PL, Makela SI. Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol. 2004;92:297–305.

    Article  PubMed  Google Scholar 

  • Hassan MI, Aijaz A, Ahmad F. Structural and functional analysis of human prostatic acid phosphatase. Expert Rev Anticancer Ther. 2010;10:1055–68.

    Article  CAS  PubMed  Google Scholar 

  • Ikeda K, Pant B, Mishiro A, Ozawa K, Masujima T, Sugiyama M. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle. J Biosci Bioeng. 2000;90:574–6.

    Article  CAS  PubMed  Google Scholar 

  • Kong HY, Byun J. Emerging roles of human prostatic acid phosphatase. Biomol Ther (Seoul). 2013;21(1):10–20.

    Article  CAS  Google Scholar 

  • Lee CH, Akin-Olugbade O, Kirschenbaum A. Overview of prostate anatomy, histology, and pathology. Endocrinol Metab Clin North Am. 2011;40:565–75.

    Article  CAS  PubMed  Google Scholar 

  • Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao HM, et al. Suppressor role of androgen receptor 1 in proliferation of prostate basal epithelial and progenitor cells. J Endocrinol. 2012;213:173–82.

    Article  CAS  PubMed  Google Scholar 

  • Long RM, Morrissey C, Fitzpatrick JM, Watson RWG. Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies. Clin Sci. 2005;108:1–11.

    Article  CAS  PubMed  Google Scholar 

  • Lowsley OS. The development of the human prostate gland with reference to the development of other structures at the neck of the urinary bladder. Am J Anat. 1912;13:299–349.

    Article  Google Scholar 

  • Mani Maran RR, Subramanian S, Rajendiran G, Sunil N, Archunan G, Arunakaran J, Govindarajulu P, et al. Prostate-thyroid axis: stimulatory effects of ventral prostate secretions on thyroid function. Prostate. 1998;36(1):8–13.

    Article  CAS  PubMed  Google Scholar 

  • McGarvey TW, Sterans ME. Keratinocyte growth factor and receptor mRNA expression in benign and malignant human prostate. Exp Mol Pathol. 1995;63:52–62.

    Article  CAS  PubMed  Google Scholar 

  • McNeal JE. The zonal anatomy of the prostate. Prostate. 1981;2(1):35–49.

    Article  CAS  PubMed  Google Scholar 

  • Mimeault M, Mehta PP, Hauke R, Batra SK. Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies. Endocr Rev. 2008;29:234–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mink PJ, Adami HO, Trichopoulos D, Britton NL, Mandel JS. Pesticides and prostate cancer: a review of epidemiologic studies with specific agricultural exposure information. Eur J Cancer Prev. 2008;17(2):97–110.

    Article  PubMed  Google Scholar 

  • Mondul AM, Weinstein SJ, Bosworth T, Remaley AT, Virtamo J, Albanes D. Circulating thyroxine, thyroid-stimulating hormone, and hypothyroid status and the risk of prostate cancer. PLoS One. 2012;7(10):e47730.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muniyan S, Chaturvedi NK, Dwyer JG, LaGrange CA, Chaney WG, Lin MF. Human prostatic acid phosphatase: structure, function and regulation. Int J Mol Sci. 2013;14:10438–64.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nicholson HD, Whittington K. Oxytocin and the human prostate in health and disease. Int Rev Cytol. 2007;263:253–86.

    Article  CAS  PubMed  Google Scholar 

  • Peehl DM. Primary cell cultures as models of prostate cancer development. Endocr Relat Cancer. 2005;12:19–47.

    Article  CAS  PubMed  Google Scholar 

  • Prabhav T, Bairy L. Pharmacotherapy of benign prostatic hyperplasia. JPBS. 2009;22:6–11.

    Google Scholar 

  • Prins GS, Putz O. Molecular signaling pathways that regulate prostate gland development. Differentiation. 2008;76(6):641–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prins GS, Korach KS. The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids. 2008;73(3):233–44.

    Article  CAS  PubMed  Google Scholar 

  • Reynolds RA, Kyprianou N. Growth factor signalling in prostatic growth: significance in tumour development and therapeutic targeting. Br J Pharmacol. 2006;147:144–52.

    Article  Google Scholar 

  • Ross MH, Pawlina W. Male reproductive system. In:Histology, a text and atlas. 5th ed. Baltimore: Lippincott Williams and Wilkins; 2006. p. 728–71.

    Google Scholar 

  • Russel PJ, Bennett S, Stricker P. Growth factor involvement in progression of prostate cancer. Clin Chem. 1998;44(4):705–23.

    Google Scholar 

  • Scarano WR, Toledo FC, Guerra MT, de Campos SG, Junior LA, Felisbino SL, et al. Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: proliferative and inflammatory disorders and a possible role of androgens. Toxicology. 2009;262(3):215–23.

    Article  CAS  PubMed  Google Scholar 

  • Schalken J. Androgen-receptor mediated growth of prostate cancer. Eur Urol Suppl. 2005;4:4–11.

    Article  CAS  Google Scholar 

  • Settimi L, Masina A, Andrion A, Axelson O. Prostate cancer and exposure to pesticides in agricultural settings. Int J Cancer. 2003;104(4):458–61.

    Article  CAS  PubMed  Google Scholar 

  • Shen MM, Abate-Shen C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 2010;24:1967–2000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sherwood ER, Fong C-J, Lee C, Kozlowsski JM. Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate. Endocrinology. 1992;130:2955–63.

    Article  CAS  PubMed  Google Scholar 

  • Shimasaki S, Kelly Moore R, Otsuka F, Erickson GF. The bone morphogenetic protein system in the mammalian reproduction. Endocr Rev. 2004;25:72–101.

    Article  CAS  PubMed  Google Scholar 

  • Siddiqui MK, Srivastava S, Mehrotra PK. Environmental exposure to lead as a risk for prostate cancer. Biomed Environ Sci. 2002;15(4):298–305.

    CAS  PubMed  Google Scholar 

  • Standring S. Prostate. In: Gray’s anatomy. 39th ed. Elsevier/Churchill Livingstone; 2005. p. 1301–1304.

    Google Scholar 

  • Taplin ME. Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007;4(4):236–44.

    Article  CAS  PubMed  Google Scholar 

  • Taylor RA, Toivanen R, Risbridger GP. Stem cells in prostate cancer: treating the root of the problem. Endocr Relat Cancer. 2010;17:273–85.

    Article  Google Scholar 

  • Thackare H, Nicholson HD, Whittington K. Oxytocin: its role in male reproduction and new potential therapeutic uses. Hum Reprod Update. 2006;12(4):437–48.

    Article  CAS  PubMed  Google Scholar 

  • Vashchenko N, Abrahamsson PA. Neuroendocrine differentiation in prostate cancer: implications for new treatment modalities. Eur Urol. 2005;47:147–55.

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Hayward WS, Thayer MCKA, Cunha GR. Cell differentiation lineage in the prostate. Differentiation. 2001;68:270–9.

    Article  CAS  PubMed  Google Scholar 

  • Zhu W, Young CY. Androgen-dependent transcriptional regulation of the prostate-specific antigen gene by thyroid hormone 3,5,3'-L-triiodothyronine. J Androl. 2001;22(1):136–41.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India

    Mona Sharma MD, DNB, MAMS, Surabhi Gupta PhD, Bodhana Dhole PhD & Anand Kumar MD, FAMS

Authors
  1. Mona Sharma MD, DNB, MAMS
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  2. Surabhi Gupta PhD
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  3. Bodhana Dhole PhD
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  4. Anand Kumar MD, FAMS
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Corresponding author

Correspondence to Mona Sharma MD, DNB, MAMS .

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Editors and Affiliations

  1. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India

    Anand Kumar

  2. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India

    Mona Sharma

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Sharma, M., Gupta, S., Dhole, B., Kumar, A. (2017). The Prostate Gland. In: Kumar, A., Sharma, M. (eds) Basics of Human Andrology. Springer, Singapore. https://doi.org/10.1007/978-981-10-3695-8_2

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