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Functional Aspects of Activated Protein C (APC) in Regulating Homeostasis and Disease

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Proteases in Human Diseases

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Abstract

Activated protein C is an intrinsic cytoprotective, anti-inflammatory, and anticoagulant factor. It acts as an active therapeutic molecule against the progression of number of systemic disorders. APC performs majority of its cell survival and homeostatic activities through binding with EPCR and activation of PAR1. Future research on the multifunctionality of APC protein may provide a novel insight into the mechanisms and interrelation of various coagulation and systemic disorders to provide an improved pathophysiological therapeutic approach to diseases.

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Authors and Affiliations

  1. Department of Biological Chemistry, Indian Association for the Cultivation of Science, 2A & 2B Raja S C Mullick Road, Poddar Nagar, Jadavpur, 700032, Kolkata, India

    Ramesh Prasad, Abhishek Roy & Prosenjit Sen

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  1. Ramesh Prasad
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  2. Abhishek Roy
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  3. Prosenjit Sen
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Correspondence to Prosenjit Sen .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Faculty of Medicine, St. Boniface General Hospital, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Prasad, R., Roy, A., Sen, P. (2017). Functional Aspects of Activated Protein C (APC) in Regulating Homeostasis and Disease. In: Chakraborti, S., Chakraborti, T., Dhalla, N. (eds) Proteases in Human Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-3162-5_18

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