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Trauma, Regulated Cell Death, and Inflammation

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Advanced Trauma and Surgery

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Abstract

Trauma is a significant regulator of cell death , which, in turn, plays an important role in the regulation of inflammation. The efficacy of tissue homeostasis includes several factors such as the removal of foreign microbial pathogens and the removal and identification of dead and dying cells. Further research has led to an enhanced knowledge on the connection between cell death and inflammation, expanding past understanding of the signaling pathways that regulate and affect different forms of cell death and inflammatory responses. This chapter presents an overview of the major types of cell death related to inflammation and the mechanisms underlying trauma regulation of cell death. The impact of these cell death pathways allows for the identification of a therapeutic target for inflammatory diseases.

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Authors and Affiliations

  1. School of Medicine and Veterans Affairs Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA, 15240, USA

    Jie Fan

  2. School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    Liyan Fan

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  1. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, The first Affiliated Hospital of PLA General Hospital, Beijing, Beijing, China

    Xiaobing Fu

  2. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, Daping Hospital, Chongqing, Chong Qing, China

    Liangming Liu

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Fan, J., Fan, L. (2017). Trauma, Regulated Cell Death, and Inflammation. In: Fu, X., Liu, L. (eds) Advanced Trauma and Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-2425-2_16

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