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Childhood Sarcoidosis

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Pediatric Rheumatology

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References

  1. Hunninghake GW, Costabel U, Ando M, Baughman R, Cordier JF, du Bois R, et al. ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis. 1999;16(2):149–73.

    CAS  PubMed  Google Scholar 

  2. Hoffmann AL, Milman N, Byg KE. Childhood sarcoidosis in Denmark 1979–1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Paediatr. 2004;93(1):30–6.

    Article  CAS  PubMed  Google Scholar 

  3. Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, et al. Epidemiology of sarcoidosis in Japan. Eur Respir J. 2008;31(2):372–9.

    Article  CAS  PubMed  Google Scholar 

  4. Ishige I, Usui Y, Takemura T, Eishi Y. Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis. Lancet. 1999;354(9173):120–3.

    Article  CAS  PubMed  Google Scholar 

  5. Hua B, Li QD, Wang FM. Borrelia burgdorferi may be the causal agent of sarcoidosis. Zhonghua Nei Ke Za Zhi. 1992;30(10):631–3, 659.

    CAS  PubMed  Google Scholar 

  6. Bocart D, Lecossier D, De Lassence A, Valeyre D, Battesti JP, Hance AJ. A search for mycobacterial DNA in granulomatous tissues from patients with sarcoidosis using the polymerase chain reaction. Am Rev Respir Dis. 1992;145(5):1142–8.

    Article  CAS  PubMed  Google Scholar 

  7. Martinetti M, Tinelli C, Kolek V, Cuccia M, Salvaneschi L, Pasturenzi L, et al. “The sarcoidosis map”: a joint survey of clinical and immunogenetic findings in two European countries. Am J Respir Crit Care Med. 1995;152(2):557–64.

    Article  CAS  PubMed  Google Scholar 

  8. Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, et al. Identification of immune-relevant factors conferring sarcoidosis genetic risk. Am J Respir Crit Care Med. 2015;192(6):727–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zissel G, Prasse A, Muller-Quernheim J. Sarcoidosis – immunopathogenetic concepts. Semin Respir Crit Care Med. 2007;28(1):3–14.

    Article  PubMed  Google Scholar 

  10. Kita S, Tsuda T, Sugisaki K, Miyazaki E, Matsumoto T. Characterization of distribution of T lymphocyte subsets and activated T lymphocytes infiltrating into sarcoid lesions. Intern Med. 1995;34(9):847–55.

    Article  CAS  PubMed  Google Scholar 

  11. Kieszko R, Krawczyk P, Jankowska O, Chocholska S, Krol A, Milanowski J. The clinical significance of interleukin 18 assessment in sarcoidosis patients. Respir Med. 2007;101(4):722–8.

    Article  PubMed  Google Scholar 

  12. Kanazawa N. Clinical features of Blau syndrome and early-onset sarcoidosis and associating CARD15/NOD2 gene mutations. Nihon Rinsho Meneki Gakkai Kaishi. 2007;30(2):123–32.

    Article  PubMed  Google Scholar 

  13. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999;274(21):14560–7.

    Article  CAS  PubMed  Google Scholar 

  14. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 2001;276(7):4812–8.

    Article  CAS  PubMed  Google Scholar 

  15. Wouters CH, Maes A, Foley KP, Bertin J, Rose CD. Blau syndrome, the prototypic auto-inflammatory granulomatous disease. Pediatr Rheumatol Online J. 2014;12:33.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, et al. Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Arthritis Rheum. 2009;60(1):242–50.

    Article  CAS  PubMed  Google Scholar 

  17. Rose CD, Pans S, Casteels I, Anton J, Bader-Meunier B, Brissaud P, et al. Blau syndrome: cross-sectional data from a multicentre study of clinical, radiological and functional outcomes. Rheumatology (Oxford). 2015;54(6):1008–16.

    Article  Google Scholar 

  18. Rose CD, Wouters CH, Meiorin S, Doyle TM, Davey MP, Rosenbaum JT, et al. Pediatric granulomatous arthritis: an international registry. Arthritis Rheum. 2006;54(10):3337–44.

    Article  PubMed  Google Scholar 

  19. Arostegui JI, Arnal C, Merino R, Modesto C, Antonia Carballo M, Moreno P, et al. NOD2 gene-associated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1 blockade in a Spanish cohort. Arthritis Rheum. 2007;56(11):3805–13.

    Article  CAS  PubMed  Google Scholar 

  20. Carlos Daniel Rosé CW. Pediatric sarcoidosis. In: Petty RE, Laxer RM, Lindsley CB, Wedderburn L, Cassidy JT, editors. Textbook of pediatric rheumatology, 7th ed. p. 1 online resource.

    Google Scholar 

  21. Cimaz R, Ansell BM. Sarcoidosis in the pediatric age. Clin Exp Rheumatol. 2002;20(2):231–7.

    CAS  PubMed  Google Scholar 

  22. Yanardag H, Pamuk ON, Karayel T. Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med. 2003;97(8):978–82.

    Article  PubMed  Google Scholar 

  23. Pattishall EN, Kendig Jr EL. Sarcoidosis in children. Pediatr Pulmonol. 1996;22(3):195–203.

    Article  CAS  PubMed  Google Scholar 

  24. Jamilloux Y, Kodjikian L, Broussolle C, Seve P. Sarcoidosis and uveitis. Autoimmun Rev. 2014;13(8):840–9.

    Article  PubMed  Google Scholar 

  25. Baumann RJ, Robertson Jr WC. Neurosarcoid presents differently in children than in adults. Pediatrics. 2003;112(6 Pt 1):e480–6.

    Article  PubMed  Google Scholar 

  26. Gallucci M, Smith JD, Limbucci N, Rossi A, Demaerel P, Krings T, et al. Pediatric inflammatory diseases. Part IV: miscellaneous, reye, PRES, sarcoidosis. Neuroradiol J. 2012;25(6):725–38.

    Article  CAS  PubMed  Google Scholar 

  27. Coutant R, Leroy B, Niaudet P, Loirat C, Dommergues JP, Andre JL, et al. Renal granulomatous sarcoidosis in childhood: a report of 11 cases and a review of the literature. Eur J Pediatr. 1999;158(2):154–9.

    Article  CAS  PubMed  Google Scholar 

  28. Dimitriades C, Shetty AK, Vehaskari M, Craver RD, Gedalia A. Membranous nephropathy associated with childhood sarcoidosis. Pediatr Nephrol. 1999;13(5):444–7.

    Article  CAS  PubMed  Google Scholar 

  29. Milman N, Hoffmann AL, Byg KE. Sarcoidosis in children. Epidemiology in Danes, clinical features, diagnosis, treatment and prognosis. Acta Paediatr. 1998;87(8):871–8.

    Article  CAS  PubMed  Google Scholar 

  30. Keesling CA, Frush DP, O’Hara SM, Fordham LA. Clinical and imaging manifestations of pediatric sarcoidosis. Acad Radiol. 1998;5(2):122–32.

    Article  CAS  PubMed  Google Scholar 

  31. Fernandes SR, Singsen BH, Hoffman GS. Sarcoidosis and systemic vasculitis. Semin Arthritis Rheum. 2000;30(1):33–46.

    Article  CAS  PubMed  Google Scholar 

  32. Wouters CH, Martin TM, Stichweh D, Punaro M, Doyle TM, Lewis JA, et al. Infantile onset panniculitis with uveitis and systemic granulomatosis: a new clinicopathologic entity. J Pediatr. 2007;151(6):707–9.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Beneteau-Burnat B, Baudin B, Morgant G, Baumann FC, Giboudeau J. Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference interval for adults. Clin Chem. 1990;36(2):344–6.

    CAS  PubMed  Google Scholar 

  34. Song GG, Kim JH, Lee YH. Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16(1):219–26.

    Article  CAS  PubMed  Google Scholar 

  35. Gungor S, Ozseker F, Yalcinsoy M, Akkaya E, Can G, Eroglu H, et al. Conventional markers in determination of activity of sarcoidosis. Int Immunopharmacol. 2015;25(1):174–9.

    Article  CAS  PubMed  Google Scholar 

  36. Costabel U, Bonella F, Ohshimo S, Guzman J. Diagnostic modalities in sarcoidosis: BAL, EBUS, and PET. Semin Respir Crit Care Med. 2010;31(4):404–8.

    Article  PubMed  Google Scholar 

  37. Sulavik SB, Spencer RP, Weed DA, Shapiro HR, Shiue ST, Castriotta RJ. Recognition of distinctive patterns of gallium-67 distribution in sarcoidosis. J Nucl Med Off Publ Soc Nucl Med. 1990;31(12):1909–14.

    CAS  Google Scholar 

  38. Chen ES, Song Z, Willett MH, Heine S, Yung RC, Liu MC, et al. Serum amyloid a regulates granulomatous inflammation in sarcoidosis through toll-like receptor-2. Am J Respir Crit Care Med. 2010;181(4):360–73.

    Article  CAS  PubMed  Google Scholar 

  39. Judson MA. Advances in the diagnosis and treatment of sarcoidosis. F1000 Prime Rep. 2014;6:89.

    Article  Google Scholar 

  40. Panselinas E, Judson MA. Acute pulmonary exacerbations of sarcoidosis. Chest. 2012;142(4):827–36.

    Article  CAS  PubMed  Google Scholar 

  41. Gedalia A, Molina JF, Ellis Jr GS, Galen W, Moore C, Espinoza LR. Low-dose methotrexate therapy for childhood sarcoidosis. J Pediatr. 1997;130(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  42. Cremers JP, Drent M, Bast A, Shigemitsu H, Baughman RP, Valeyre D, et al. Multinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosis: integrating systematic literature research and expert opinion of sarcoidologists worldwide. Curr Opin Pulm Med. 2013;19(5):545–61.

    Article  CAS  PubMed  Google Scholar 

  43. Schutt AC, Bullington WM, Judson MA. Pharmacotherapy for pulmonary sarcoidosis: a Delphi consensus study. Respir Med. 2010;104(5):717–23.

    Article  PubMed  Google Scholar 

  44. Yasui K, Yashiro M, Tsuge M, Manki A, Takemoto K, Yamamoto M, et al. Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism. Arthritis Rheum. 2010;62(1):250–7.

    Article  CAS  PubMed  Google Scholar 

  45. La Torre F, Lapadula G, Cantarini L, Lucherini OM, Iannone F. Early-onset sarcoidosis caused by a rare CARD15/NOD2 de novo mutation and responsive to infliximab: a case report with long-term follow-up and review of the literature. Clin Rheumatol. 2015;34(2):391–5.

    Article  PubMed  Google Scholar 

  46. Milman N, Andersen CB, Hansen A, van Overeem HT, Nielsen FC, Fledelius H, et al. Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation. APMIS Acta Pathol Microbiol et Immunol Scand. 2006;114(12):912–9.

    Article  Google Scholar 

  47. Simonini G, Taddio A, Cattalini M, Caputo R, de Libero C, Parentin F, et al. Superior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic modifier drug: Adalimumab as starting anti-TNF-alpha therapy in childhood chronic uveitis. Pediatr Rheumatol Online J. 2013;11:16.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Achille M, Ilaria P, Teresa G, Roberto C, Ilir A, Piergiorgio N, et al. Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. Int Ophthalmol. 2016;36(1):129–35.

    Article  PubMed  Google Scholar 

  49. Parente Costa L, Bonfa E, Martinago CD, de Oliveira RM, Carvalho JF, Pereira RM. Juvenile onset Systemic Lupus Erythematosus thyroid dysfunction: a subgroup with mild disease? J Autoimmun. 2009;33(2):121–4.

    Article  PubMed  Google Scholar 

  50. Simonini G, Xu Z, Caputo R, De Libero C, Pagnini I, Pascual V, et al. Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis. Arthritis Rheum. 2013;65(2):513–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Burns AM, Green PJ, Pasternak S. Etanercept-induced cutaneous and pulmonary sarcoid-like granulomas resolving with adalimumab. J Cutan Pathol. 2012;39(2):289–93.

    Article  PubMed  Google Scholar 

  52. Louie GH, Chitkara P, Ward MM. Relapse of sarcoidosis upon treatment with etanercept. Ann Rheum Dis. 2008;67(6):896–8.

    Article  CAS  PubMed  Google Scholar 

  53. Cinetto F, Compagno N, Scarpa R, Malipiero G, Agostini C. Rituximab in refractory sarcoidosis: a single centre experience. Clin Mol Allergy CMA. 2015;13(1):19.

    Article  PubMed  Google Scholar 

  54. Sweiss NJ, Lower EE, Mirsaeidi M, Dudek S, Garcia JG, Perkins D, et al. Rituximab in the treatment of refractory pulmonary sarcoidosis. Eur Respir J. 2014;43(5):1525–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Milman N, Hoffmann AL. Childhood sarcoidosis: long-term follow-up. Eur Respir J. 2008;31(3):592–8.

    Article  CAS  PubMed  Google Scholar 

  56. Fink CW, Cimaz R. Early onset sarcoidosis: not a benign disease. J Rheumatol. 1997;24(1):174–7.

    CAS  PubMed  Google Scholar 

  57. Hafner R, Vogel P. Sarcoidosis of early onset. A challenge for the pediatric rheumatologist. Clin Exp Rheumatol. 1993;11(6):685–91.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Rheumatology, Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India

    Sumidha Mittal

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  1. Sumidha Mittal
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Correspondence to Sumidha Mittal .

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Editors and Affiliations

  1. Pediatric Rheumatology Division Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India

    Sujata Sawhney

  2. Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Amita Aggarwal

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Mittal, S. (2017). Childhood Sarcoidosis. In: Sawhney, S., Aggarwal, A. (eds) Pediatric Rheumatology. Springer, Singapore. https://doi.org/10.1007/978-981-10-1750-6_46

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  • DOI: https://doi.org/10.1007/978-981-10-1750-6_46

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