Abstract
The purpose of long-term oxygen therapy, which has been called home oxygen therapy (HOT) in Japan, for chronic respiratory failure is to prevent severe hypoxemia and the development of pulmonary hypertension, and improve mortality. The recommendations for HOT are based on the MRC and NOTT studies performed over 30 years ago. The indications for HOT based on the two studies may not necessarily be representative of today’s COPD patients. There is no concrete evidence concerning the effects of HOT on the prevention of pulmonary hypertension, improvement of ADL, QOL, and physical activity, and little beneficial evidence for patients with mild to moderate hypoxemia at rest or daytime, except for exercise-induced severe hypoxemia, nocturnal oxygen desaturation, comorbidities such as cardio- and cerebrovascular comorbidities, or severe breathlessness on exertion. Further examination will be necessary in the future during the development of a new oxygen supplying device. At the time of HOT prescription, we let the patients and their family understand the need for HOT and educate them in the directions for use. We should explain and guide them in how to use the oxygen supply apparatus safely, the confirmation of the prescribed oxygen flow, the management and maintenance of the oxygen supplying device, communication for a disaster and emergency, concerns about daily life, the prevention and correspondence of the exacerbation, the use of the welfare system, and medical expenses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Japanese White Paper on Home Respiratory Care. The Japanese respiratory society and the respiratory failure research group from the Ministry of Health, Labour, and Welfare. Tokyo: Medical Tribune Co. Ltd; 2010.
Medical Research Council Working Party. Report of long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet. 1981;1:681–6.
Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med. 1980;93:391–8.
Petty TL, Bliss PL. Ambulatory oxygen therapy, exercise, and survival with advanced chronic obstructive pulmonary disease (the Nocturnal Oxygen Therapy Trial revisited). Respir Care. 2000;45:204–11.
Kira S, Aiba M, Suzuki T, Ishihara T, Takahashi H, Hasunuma K, et al. Improvement of prognosis in patients with chronic respiratory failure using home oxygen therapy. In: Kira S, Petty TL, editors. Progress in domiciliary respiratory care. Amsterdam: Elsevier Science; 1994. p. 337–44.
Miyamoto K, Aida A, Nishimura M, Aiba M, Kira S, Kawakami Y, et al. Gender effect on prognosis of patients receiving long-term home oxygen therapy. The Respiratory Failure Research Group in Japan. Am J Respir Crit Care Med. 1995;152:972–6.
Ekstrom M, Franklin KA, Strom KE. Increased relative mortality in women with severe oxygen-dependent COPD. Chest. 2010;137:31–6.
Fujimoto K, Matsuzawa Y, Yamaguchi S, Koizumi T, Kubo K. Benefits of oxygen on exercise performance and pulmonary hemodynamics in COPD with mild hypoxemia. Chest. 2002;122:457–63.
Cooper CB, Waterhouse J, Howardt P. Twelve year clinical study of patients with hypoxic cor pulmonale given long term domiciliary oxygen therapy. Thorax. 1987;42:105–10.
Zieliriski J, Tobiasz M, Hawrylkiewicz I, Sliwinski P, Palasiewicz G. Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients: a 6-year prospective study. Chest. 1998;113:65–70.
Heaton RK, Grant L, McSweeny AJ, Adams KM, Petty TL. Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med. 1983;143:1941–7.
Okubadejo AA, O’Shea L, Jones PW, Wedzicha JA. Home assessment of activities of daily living in patients with severe chronic obstructive pulmonary disease on long-term oxygen therapy. Eur Respir J. 1997;10:1572–5.
Eaton T, Lewis C, Young P, Kennedy Y, Garrett JE, Kolbe J. Long-term oxygen therapy improves health-related quality of life. Respir Med. 2004;98:285–93.
Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187:347–65.
Celli BR, MacNee W, ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004;23:932–46.
McDonald CF, Crockett AJ, Young AH. Adult domiciliary oxygen therapy. Position statement of the Thoracic Society of Australia and New Zealand. Med J Aust. 2005;182:621–6.
Górecka D, Gorzelak K, Sliwiński P, Tobiasz M, Zieliński J. Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia. Thorax. 1997;52:674–9.
Moore RP, Berlowitz DJ, Denehy L, Pretto JJ, Brazzale DJ, Sharpe K, et al. A randomised trial of domiciliary, ambulatory oxygen in patients with COPD and dyspnoea but without resting hypoxaemia. Thorax. 2011;66:32–7.
Horsfield K, Segel N, Bishop JM. The pulmonary circulation in chronic bronchitis at rest and during exercise breathing air and 80 per cent oxygen. Clin Sci. 1968;34:473–83.
Bradley JM, O’Neill B. Short-term ambulatory oxygen for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2005; CD004356.
O’Donnell DE, Laveneziana P. The clinical importance of dynamic lung hyperinflation in COPD. COPD. 2006;3:219–32.
Casanova C, Cote C, Martin JM, Pinto-Plata V, de Torres JP, Aguirre-Jaíme A, et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest. 2008;134:746–52.
Garcia-Talavera I, Tauroni A, Trujillo JL, Pitti R, Eiroa L, Aguirre-Jaime A, et al. Time to desaturation less than one minute predicts the need for long-term home oxygen therapy. Respir Care. 2011;56:1812–7.
Eaton T, Garrett JE, Young P, Fergusson W, Kolbe J, Rudkin S, et al. Ambulatory oxygen improves quality of life of COPD patients: a randomised controlled study. Eur Respir J. 2002;20:306–12.
Liss HP, Grant BJ. The effect of nasal flow on breathlessness in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1988;137:1285–8.
Sabit R, Thomas P, Shale DJ, Collins P, Linnane SJ. The effects of hypoxia on markers of coagulation and systemic inflammation in patients with COPD. Chest. 2010;138:47–51.
van Helvoort HA, Heijdra YF, Heunks LM, Meijer PL, Ruitenbeek W, Thijs HM, et al. Supplemental oxygen prevents exercise-induced oxidative stress in muscle-wasted patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:1122–9.
Tarpy SP, Celli BR. Long-term oxygen therapy. N Engl J Med. 1995;333:710–4.
Nonoyama M, Brooks D, Lacasse Y, Guyatt GH, Goldstein R. Oxygen therapy during exercise training in chronic obstructive pulmonary disease (Review) Cochrane Database Syst Rev 2007: CD005372.
Nonoyama ML, Brooks D, Guyatt GH, Goldstein RS. Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia. Am J Respir Crit Care Med. 2007;176:343–9.
Spielmanns M, Fuchs-Bergsma C, Winkler A, Fox G, Krüger S, Baum K. Effects of oxygen supply during training on subjects with COPD who are normoxemic at rest and during exercise: a blinded randomized controlled trial. Respir Care. 2015;60:540–8.
Garrod R, Mikelsons C, Paul EA, Wedzicha JA. Randomized controlled trial of domiciliary noninvasive positive pressure ventilation and physical training in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:1335–41.
Palange P, Valli G, Onorati P, Antonucci R, Paoletti P, Rosato A, et al. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J Appl Physiol. 2004;97:1637–42.
McNicholas WT, Verbraecken J, Marin JM. Sleep disorders in COPD: the forgotten dimension. Eur Respir Rev. 2013;22:365–75.
Fletcher EC, Luckett RA, Miller T, Costarangos C, Kutka N, Fletcher JG. Pulmonary vascular hemodynamics in chronic lung disease patients with and without oxyhemoglobin desaturation during sleep. Chest. 1989;95:757–64.
Fletcher EC, Luckett RA, Goodnight-White S, Miller CC, Qian W, Costarangos-Galarza C. A double-blind trial of nocturnal supplemental oxygen for sleep desaturation in patients with chronic obstructive pulmonary disease and a daytime PaO2 above 60 mmHg. Am Rev Respir Dis. 1992;145:1070–6.
Chaouat A, Weitzenblum E, Kessler R, Charpentier C, Enrhart M, Schott R, et al. A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients. Eur Respir J. 1999;14:1002–8.
Lewis CA, Fergusson W, Eaton T, Zeng I, Kolbe J. Isolated nocturnal desaturation in COPD: prevalence and impact on quality of life and sleep. Thorax. 2009;64:133–8.
Chaouat A, Weitzenblum E, Krieger J, Ifoundza T, Oswald M, Kessler R. Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med. 1995;151:82–6.
Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea. The overlap syndrome. Am J Respir Crit Care Med. 2010;182:325–31.
Cottin V, Nunes H, Brillet P-Y, Delaval P, Devouassoux G. I. Tillie-Leblond I, et al. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005;26:586–93.
Weitzenblum E, Chaouat A, Kessler R. Long-term oxygen therapy in stable COPD. In: Similowski T, Whitelaw WA, Derenne J, editors. Clinical management of chronic obstructive pulmonary disease. New York: Marcel Dekker; 2002. p. 781–812.
Selinger SR, Kennedy TP, Buescher P, Terry P, Parham W, Gofreed D, et al. Effects of removing oxygen from patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1987;136:85–91.
Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicenter, randomized, controlled clinical trial. Lancet Respir Med. 2014;2:698–705.
Palwai A, Skowronski M, Coreno A, Drummond C, McFadden Jr ER. Critical comparisons of the clinical performance of oxygen-conserving devices. Am J Respir Crit Care Med. 2010;181:1061–71.
Lobato SD, Alises SM. Mobility profiles of patients with home oxygen therapy. Arch Bronconeumol. 2012;48:55–60.
Garcia-Aymerich J, Monsó E, Marrades RM, Escarrabill J, Félez MA, Sunyer J, et al. Risk factors for hospitalization for a chronic obstructive pulmonary disease excacerbation EFRAM study. Am J Respir Crit Care Med. 2001;164:1002–7.
Rice KL, Dewan N, Bloomfield HE, Grill J, Schult TM, Nelson DB, et al. Disease management program for chronic obstructive pulmonary disease. A randomized controlled trial. Am J Respir Crit Care Med. 2010;182:890–6.
Gong Jr H. Air travel and oxygen therapy in cardiopulmonary patients. Chest. 1992;101:1104–13.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media Singapore
About this chapter
Cite this chapter
Fujimoto, K. (2017). Long-Term Oxygen Therapy (or Home Oxygen Therapy) for COPD: The Present State and Future Problems. In: Nakamura, H., Aoshiba, K. (eds) Chronic Obstructive Pulmonary Disease. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-10-0839-9_11
Download citation
DOI: https://doi.org/10.1007/978-981-10-0839-9_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-0838-2
Online ISBN: 978-981-10-0839-9
eBook Packages: MedicineMedicine (R0)