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Roles of HSF1 and Heat Shock Proteins in Cancer

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Hyperthermic Oncology from Bench to Bedside

Abstract

Heat shock proteins (HSPs) that are induced by various stresses, such as heat, work to protect cells from detrimental environmental stresses as molecular chaperones. The expression of HSPs is regulated by a specific transcription factor HSF1 (heat shock factor 1). The HSF1-HSPs system has long been considered to have an endogenous cytoprotective function. It has recently been shown, however, that HSF1 and HSPs are essential for cancer cell development and progression, and the HSF1-HSPs system seems to be co-opted or hijacked by cancer cells for their own survival. In this review, recent progress in understanding the roles of HSF1 and HSPs in cancer is discussed.

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Authors and Affiliations

  1. Laboratory of Cell & Stress Biology, College of Bioscience & Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan

    Kenzo Ohtsuka

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  1. Kenzo Ohtsuka
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Correspondence to Kenzo Ohtsuka .

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Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

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Ohtsuka, K. (2016). Roles of HSF1 and Heat Shock Proteins in Cancer. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_4

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  • DOI: https://doi.org/10.1007/978-981-10-0719-4_4

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