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Efficacy of Hyperthermia in Combination With Chemotherapy for Breast Cancer

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Hyperthermic Oncology from Bench to Bedside

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Abstract

Background: We previously reported that doxorubicin and cyclophosphamide (DC) followed by weekly paclitaxel is an active and manageable preoperative regimen for breast cancer patients (JBCRN-02 Trial).

Patients and Methods: We retrospectively investigated that the efficacy of hyperthermia in combination with chemotherapy for breast cancer. Four cycles of DC (doxorubicin: 60 mg/m2 and cyclophosphamide: 600 mg/m2) administered intravenously (i.v.) on day 1 every 21 days were followed by 12 cycles of paclitaxel i.v. (80 mg/m2) every 7 days, prior to surgery. During chemotherapy, hyperthermia was performed using a Thermotron RF-8 capacitive heating device.

Results: 5 patients received hyperthermia during chemotherapy. The patient population was identified from a database of the Japan Breast Cancer Research Network. Clinical responses were rated as cPR in 4 patients (80 %), and cSD in 1 patient (20 %). Further, the cPR rate in ER/PgR– tumor was 100 %, while it in ER/PgR+ was 50 %. The value of Ki67 remarkably decreased in 4cases (80 %) and we observed significant association between Ki67 values and clinical response. In addition, 2 patients who developed grade 1 dermatitis during hyperthermia.

Conclusion: there is a possibility that high-Ki67 may become predictive factor in clinical response of neoadjuvant chemotherapy and hyperthermia.

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Authors and Affiliations

  1. Department of Surgery, Kansai Medical University, Takii Hospital, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan

    Daigo Yamamoto

  2. Internal medicine, Seiko Hospital, Osaka, Japan

    Daigo Yamamoto & Chizuko Yamamoto

  3. Department of Palliative Medicine, the institute of medical science, University of Tokyo Hospital, Tokyo, Japan

    Satoru Iwase

  4. Department of Surgery, Hirosaki National Hospital, Aomori, Japan

    Hiroki Odagiri

Authors
  1. Daigo Yamamoto
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  2. Chizuko Yamamoto
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  3. Satoru Iwase
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  4. Hiroki Odagiri
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Corresponding author

Correspondence to Daigo Yamamoto .

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Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

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Yamamoto, D., Yamamoto, C., Iwase, S., Odagiri, H. (2016). Efficacy of Hyperthermia in Combination With Chemotherapy for Breast Cancer. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_23

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  • DOI: https://doi.org/10.1007/978-981-10-0719-4_23

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-0717-0

  • Online ISBN: 978-981-10-0719-4

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