Abstract
Herbal medicines are widely used in Brazil and currently constitute an expanding market. Among the species with the highest number of registration entries is Maytenus ilicifolia Mart. ex Reissek, a plant species native to Brazil that has a high medicinal value.
Pharmacological pre-clinical studies have demonstrated the anti-ulcerogenic, anti-secretory, anti-inflammatory, anti-diarrhea, anti-oxidant, anti-microbial, anti-protozoal, anti-cancer and hypotensive properties of this medicinal plant. It has also been established that some of its pharmacological activities are due the presence of terpenoids, flavonoids, tannins, alkaloids and polysaccharides. The species M. ilicifolia has been used in traditional medicine since the mid-1920s. Presently, it is endangered due to the strong anthropic action in natural populations. As a medicinal plant, in Brazil, its leaves are used in homemade and industrial medicines to effectively treat stomach ulcers. Therefore, studies that validate the use of this important Brazilian native plant are warranted.
Maytenus ilicifolia Mart. ex Teissek
Photo: Julio Antonio Lombardi
Available in: https://www.kew.org/science/tropamerica/neotropikey/families/Celastraceae.htm
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alonso JR (1998) Phytomedicine Treaty clinical and pharmacological bases. Isis Ediciones SRL, Buenos Aires, pp 828–834 Spanish
Araújo-Júnior RF, Oliveira AL, Pessoa JB, Garcia VB, Guerra GC, Soares LA, Souza TP, Petrovick PR, Araújo AA (2013) Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells. Exp Biol Med 238:1251–1258
Baggio CH, Freitas CS, Otofuji GM, Cipriani TR, Souza LM, Sassaki GL, Iacomini M, Marques MCA, Mesia-Vela S (2007) Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+-ATPase activity and formation of nitric oxide. J Ethnopharmacol 113:433–440
Baggio CH, Freitas CS, Mayer B, Santos AC, Twardowschy A, Potrich FB, Cipriani TR, Souza LM, Sassaki GL, Iacomini M, Marques MCA, Mesia-Vela S (2009) Muscarinic-dependent inhibition of gastric emptying and intestinal motility by fractions of Maytenus ilicifolia Mart ex. Reissek. J Ethnopharmacol 123:385–391
Balbach A (1980) The national flora in domestic medicine. EDEL, São Paulo Portuguese
Brandão MGL, Cosenza GP, Moreira RA, Monte-Mor RLM (2006) Medicinal plants and other botanical products from the Brazilian Official Pharmacopeia. Braz J Pharmacogn 16(3):408–420
Brazilian Ministry of Health (2009) Relação Nacional de Plantas Medicinais de Interesse ao Sistema Único de Saúde (RENISUS), Ministério da Saúde. http://portalsaude.saude.gov.br/images/pdf/2014/maio/07/renisus.pdf. (Brazil)
Calixto JB (1993) Pharmacological analysis of the methanolic extract and sorocein A, a new Diels-Alder compound isolated from the roots of Sorocea bonplandii Bailon in the isolated rat uterus and guinea pig ileum. Gen Pharmacol 24:983–989
Camparoto ML, Teixeira RO, Mantovani MS, Vicentini VEP (2002) Effects of Maytenus ilicifolia Mart. and Bauhinia candicans Benth infusions on onion root-tip and rat bone-marrow cells. Genet Mol Biol 25(1):85–89
Carlini EA, Frochtengarten ML (1988) Clinical toxicology (Phase I) of the espinheira-santa (Maytenus ilicifolia). Brasília-Distrito Federal. 67–73. Portuguese
Carvalho RIN, Cardon LM, Jaremtchuk CC, Kanawate EM, Silva JEC (2003) Carqueja e Espinheira-Santa in the Metropolitan region of Curitiba: from production to trade. (Curitiba) Life. 44. Portuguese
Carvalho-Okano RM (1992) Taxonomic studies of the genus Maytenus Mol. Emend. Mol. (Celastraceae) of extra-Amazonian Brazil. Thesis (Doctorate in Sciences – Plant Biology), University of Campinas. 253. Portuguese
Carvalho-Okano R, Leitão Filho HF. Taxonomic studies of the genus Maytenus Mol. Emend. Mol. (Celastraceae) of extra-Amazonian Brazil. Reis, M.S.; Silva, S.R. Conservation and sustainable use of medicinal and aromatic plants: Maytenus spp., espinheira-santa. Brasília IBAMA. 2004; 11–51. Portuguese
Castro LO, Ramos RLD (2003) Botanical description, cultivation and use of Maytenus ilicifolia Mart. ex Reiss. Cancorosa ou espinheira-santa (Celastraceae). FEPAGRO, Porto Alegre, p 12 Portuguese
Cipriani TR, Mellinger CG, Souza LM, Baggio CH, Freitas CS, Marques MCA, Gorin PAJ, Sassaki GL, Iacomini MA (2006) Polysaccharide from a Tea (Infusion) of Maytenus ilicifolia Leaves with anti-ulcer protective effects. J Nat Prod 69:1018–1021
Cipriani TR, Mellinger CG, Souza LM, Baggio CH, Freitas CS, Marques MCA, Gorin PAJ, Sassaki GL, Iacomini M (2008) Acidic heteroxylans from medicinal plants and their anti-ulcer activity. Carbohydr Polym 74:274–278
Cipriani TR, Mellinger CG, Souza LM, Baggio CH, Freitas CS, Marques MCA, Gorin PAJ, Sassaki GL, Iacomini M (2009) Polygalacturonic acid: Another anti-ulcer polysaccharide from the medicinal plant Maytenus ilicifolia. Carbohydr Polym 78:361–363
Costa PM, Ferreira PMP, Bolzani VS, Furlan M, Santos VAFFM, Corsino J, Moraes MO, Costa-Lotufo LV, Montenegro RC, Pessoa C (2008) Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells. Toxicol In Vitro 22:854–863
Crestani S, Rattmann YD, Cipriani TR, Souza LM, Iacomini M, Kassuya CAL, Marques MCA, Silva-Santos JE (2009) A potent and nitric oxide-dependent hypotensive effect induced in rats by semi-purified fractions from Maytenus ilicifolia. Vasc Pharmacol 51:57–63
Cruz GL (1982) Dictionary of useful plants in Brazil, 2nd edn. Civilização Brasileira, São Paulo Portuguese
Cunha-Laura AL, Auharek SA, Oliveira RJ, Siqueira JM, Vieira MC, Leite VS, Portugal LC (2014) Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats. Genet Mol Res 13(2):3711–3720
Duarte MR, Debur MC (2005) Stem and leaf morphoanatomy of Maytenus ilificolia. Fitoterapia 76:41–49
Ferreira PM, Oliveira CN, Oliveira AB, Lopes MJ, Alzamora F, Vieira MAR (2004) A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa. Planta 219:319–324
Gonçalves de Lima O, Dálbuquerque IL, Coêlho JSB, Martins DG, Lacerda AL, Maciel GM (1969) Antimicrobial substance of higher plants. XXXI communication. Maitenin, antimicrobial with new antineoplastic isolated action Celastraceae of Pernambuco. Rev Inst Antibióticos 9(2):17–25 Portuguese
Gonzalez FG, Portela TY, Stipp EJ, Di Stasi LC (2001) Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia. J Ethnopharmacol 77:41–47
Groppo M, Simmons MP, Cappa JJ, Biral L, Lombardi JA (2014) A new species of Maytenus (Celastraceae) with fleshy fruits from eastern Brazil, with notes on the delimitation of Maytenus. Syst Bot 39(2):478–484
Gullo FP, Sardi JCO, Santos VAFFM, Sangalli-Leite F, Pitangui NS, Rossi AS, Silva ACAP, Soares LA, Silva JF, Oliveira HC, Furlan M, Silva DHS, Bolzani VS, Mendes-Giannini MJS, Fusco-Almeida AM (2012) Antifungal activity of Maytenin and Pristimerin. Evid-Based Compl Alternat Med 2012:1–6
Gutiérrez F, Estévez-Braun A, Ravelo AG, Astudillo L, Zárate R (2007) Terpenoids from the medicinal plant Maytenus ilicifolia. J Nat Prod 70:1049–1052
Horn RC, Vargas VM (2003) Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay. Mutagenesis 18:113–118
Itokawa H, Shirota O, Ikuta H, Morita H, Takeya K, Iitaka Y (1991) Triterpenes from Maytenus ilicifolia. Phytochemistry 30(11):3713–3716
Jorge RM, Leite JPV, Oliveira AB, Tagliati CA (2004) Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia. J Ethnopharmacol 94:93–100
Leite JPV, Braga FC, Romussi G, Persoli RM, Tabach R, Carlini EA, Oliveira AB (2010) Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity. J Braz Chem Soc 21:248–254
Leme TSV, Prando TBL, Gasparotto FM, Souza P, Crestan S, Souza LM, Cipriani TR, Lourenço ELB, Junior AG (2013) Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol 150:154–161
Lorenzi H, Matos FJA (2002) Medicinal plants in Brazil: natives and exotics. Instituto Plantarum, Nova Odessa, pp 120–121 Portuguese
Magalhães PM (2002) Agrotechnology for espinheira-santa. Available in: http://www.cpqba.unicamp.br/plmed/artigos/agroespsant.htm. Portuguese
Mariot MP (2005) Genetics resources of espinheira-santa (Maytenus ilicifolia e M. aquifolium) in Rio Grande do Sul. Thesis (Doctorate in Plant Breeding) – Postgraduate Course in Agronomy, Federal University of Pelotas. 131
Mariot MP, Barbieri RL (2006) Espinheira-santa: an alternative of production in small properties. Embrapa Clima Temperado, Pelotas, p 30 Portuguese
Mariot MP, Barbieri RL (2007a) Secondary metabolites and medicinal properties of espinheira-santa (Maytenus ilicifolia Mart. Ex Reiss. e M. aquifolium Mart.). Braz J Med Plants 9(3):89–99 Portuguese
Mariot MP, Barbieri RL (2007b) The associated popular knowledge to use of Espinheira-santa (Maytenus ilicifolia e M. aquifolium). Braz J Biosci 5(1):666–668 Portuguese
Mendes BG, Machado MJ, Falkenberg M (2006) Glycolipids screening of medicinal plants. Braz J Pharmacogn 16:568–575 Portuguese
Montanari T, Bevilacqua E (2002) Effect of Maytenus ilicifolia Mart. on pregnant mice. Contraception 65:171–175
Montanari T, Carvalho JE, Dolder H (1998) Effect of Maytenus ilicifolia Mart. Ex Reiss on espermatogenesis. Contraception 57:335–339
Montanari JR, Scheffer MC, Radomski MI (2004) Cultivation of espinheira-santa. In Reis MS, Silva SR (org). Conservation and sustainable use of medicinal and aromatic plants: Maytenus spp., espinheira-santa. IBAMA, Brasília, Portuguese, pp 163–180
Mossi AJ, Cansian RL, Carvalho AZ, Dariva C, Oliveira JV, Mazutti M, Filho IN, Echeverrigaray S (2004) Extraction and characterization of volatile compounds in Maytenus ilicifolia, using high-pressure CO2. Fitoterapia 75(2):168–178
Mossi AJ, Mazutti MA, Cansian RL, Oliveira D, Oliveira JV, Dallago R, Leontiev-Orlov O, Treichel H (2010) Chemical variability of volatile organic compounds and semi-volatile native populations Maytenus ilicifolia. Quim Nova 33(5):1067–1070. Portuguese
Negrelle RRB, Doni ME, Ohlson OC, Herr S (1999) [Seed production technology espinheira-santa] (Maytenus ilicifolia Mart. ex Reiss. – Celastraceae). Rev Bras Sementes 21(1):76–81. Portuguese
Nicoloso FT, Fortunato RP, Zanchetti F, Cassol LF, Eisinger SM (2000) Containers and substrates in the production of seedlings Maytenus ilicifolia e Apuleia leocarpa. Ciência Rural 30(6):987–992. Portuguese
Niero R, Andrade SF, Filho VC (2011) A Review of the Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus. Curr Pharm Des 17:1851–1871
Panizza S (1998) Plants that heal, vol 280, 3rd edn. IBRASA, São Paulo. Portuguese
Pereira AMS, Januário AH, Queiroz MEE, Biondo R, França SC (2005) Evaluation of Maytenus aquifolia Mart. and Maytenus ilicifolia Mart. chemotypes for tannins, total phenols and triterpenes. Braz J Med Plants 8:13–17
Queiroga CL, Silva GF, Dias PC, Possenti A, Carvalho JE (2000) Evaluation of the antiulcerogenic activity of friedelan-3b-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae). J Ethnopharmacol 72:465–468
Rattmann YD, Cipriani TR, Sassaki GL, Iacomini M, Rieck L, Marques MCA, Silva-Santos JE (2006) Nitric oxide-dependent vasorelaxation induced by extractive solutions and fractions of Maytenus ilicifolia Mart ex Reissek (Celastraceae) leaves. J Ethnopharmacol 104:328–335
Santos VAFFM, Santos DP, Castro-Gamboa I, Zanoni MVB, Furlan M (2010) Evaluation of antioxidant capacity and synergistic associations of Quinonemethide Triterpenes and Phenolic substances from Maytenus ilicifolia (Celastraceae). Molecules 15:6956–6973
Santos VAFFM, Regasini LO, Nogueira CR, Passerini GD, Martinez I, Bolzani VS, Graminha MAS, Cicarelli RMB, Furlan M (2012) Antiprotozoal Sesquiterpene Pyridine Alkaloids from Maytenus ilicifolia. J Nat Prod 75:991–995
Santos VAFFM, Leite KM, Siqueira MC, Regasini LO, Martinez I, Nogueira CT, Galuppo MK, Stolf BS, Pereira MAS, Cicarelli RMB, Furlan M, Graminha MAS (2013) Antiprotozoal activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae). Molecules 18:1053–1062
Santos-Oliveira R, Coulaud-Cunha S, Colaço W (2009) Review on Maytenus ilicifolia Mart. ex Reissek, Celastraceae. Contribution to the study of the pharmacological properties. Braz J Pharmacogn 19:650–659. Portuguese
Scheffer MC (2001) Mating system and genetic variation between populations and progeny “espinheira-santa” Thesis (Doctorate in Forest Engineering – Forestry). Federal University of Paraná, Curitiba. 104. Portuguese
Scheffer MC (2004) Traditional and current use of species Maytenus. In: Reis MS, Silva SR (eds) Conservation and sustainable use of medicinal and aromatic plants: Maytenus spp., espinheira-santa. IBAMA, Brasília, pp 53–66. Portuguese
Simões CMO (1989) Plants of folk medicine of Rio Grande do Sul. Ed. Da Universidade/UFRGS, Porto Alegre. Portuguese
Singh B, Dubey MM (2001) Estimation of triterpenoids from Heliotropium maifolium Kohen ex Retz in vivo and in vitro: antimicrobial screening. Phytother Res 15:231–234
Souza LM, Cipriani TR, Iacomini M, Gorin PAJ, Sassaki GLHPLC (2008) ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. J Pharm Biomed Anal 47:59–67
Souza-Formigoni MLO, Oliveira MGM, Monteiro MG, Silveira-Filho NG, Braz S, Carlini EA (1991) Antiulcerogenic effects of two Maytenus species in laboratory animals. J Ethnopharmacol 34:21–27
Teske M, Trentini AMM (1995) Compendium of herbal medicine. Herbarium. 2 ed. 128–129
Tiberti LA, Yariwake JH, Ndjoko K, Hostettmann K (2007) Identification of flavonols in leaves of Maytenus ilicifolia and M. aquifolium (Celastraceae) by LC/UV/MS analysis. J Chromatogr B 846:378–384
Valladão FN, Miranda RRS, Vale FH, Valladão SA, Silva GDF, Duarte LP, Carvalho-Okano RM, Messias MCTB, Filho SAV (2009) Four Brazilian Maytenus salicifolia Reissek (Celastraceae) groups studied by TLC and UV/Vis spectrophotometry. Brazilian. J Pharmacogn 19:733–739
Vargas VM, Guidobono RR, Henriques JA (1991) Genotoxicity of plant extracts. Mem Inst Oswaldo Cruz 86(2):67–70
Vellosa JCR, Khalil NM, Formenton VAF, Ximenes VF, Fonseca LM, Furlan M, Brunetti IL, Oliveira OMMF (2006) Antioxidant activity of Maytenus ilicifolia root bark. Fitoterapia 77:243–244
Vieira RF (1999) Conservation of medicinal and aromatic plants in Brazil. In: Janick J (ed) Perspectives on new crops and new uses. ASHS Press, Alexandria, pp 152–159
Zhu N, Sharapin N, Zhang J (1998) Three glucosides from Maytenus ilicifolia. Phytochemistry 47(2):265–268
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature B.V.
About this chapter
Cite this chapter
Périco, L.L., Rodrigues, V.P., de Almeida, L.F.R., Fortuna-Perez, A.P., Vilegas, W., Hiruma-Lima, C.A. (2018). Maytenus ilicifolia Mart. ex Reissek. In: Albuquerque, U., Patil, U., Máthé, Á. (eds) Medicinal and Aromatic Plants of South America. Medicinal and Aromatic Plants of the World, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1552-0_29
Download citation
DOI: https://doi.org/10.1007/978-94-024-1552-0_29
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-024-1550-6
Online ISBN: 978-94-024-1552-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)