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From Molecules to Crystals to Functional Form: Science of Scale

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Engineering Crystallography: From Molecule to Crystal to Functional Form

Abstract

An understanding of the materials science of a new active pharmaceutical ingredient (API) is crucial at the interface of the chemical synthesis and drug product development. The selection of the crystallisation process and particle attributes during development is a key milestone in the conversion of a new API into a drug product. The physical and chemical properties of an API can impact product performance and process robustness and are strongly influenced by the solid state structure of the API. Product performance can only be assured when the API is delivered to the patient in a chemically and physically stable solid form. In this chapter we will attempt to integrate progress with cutting edge computational tools in academia to the best current industrial practices.

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Author information

Authors and Affiliations

  1. Pharmaceutical Sciences, Pfizer Global R&D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

    Robert Docherty, Garry O’Connor & Radoslav Y. Penchev

  2. School of Chemical and Process Engineering, University of Leeds, Leeds, LS2 9JT, UK

    Jonathan Pickering & Vasuki Ramachandran

Authors
  1. Robert Docherty
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  2. Garry O’Connor
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  3. Radoslav Y. Penchev
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  4. Jonathan Pickering
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  5. Vasuki Ramachandran
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Corresponding author

Correspondence to Radoslav Y. Penchev .

Editor information

Editors and Affiliations

  1. School of Chemical & Process Engineering, University of Leeds, Leeds, United Kingdom

    Kevin J. Roberts

  2. Pfizer Global R&D, Pharmaceutical Sciences, Pfizer Global R&D, Sandwich, Kent, United Kingdom

    Robert Docherty

  3. Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, Japan

    Rui Tamura

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Docherty, R., O’Connor, G., Penchev, R.Y., Pickering, J., Ramachandran, V. (2017). From Molecules to Crystals to Functional Form: Science of Scale. In: Roberts, K., Docherty, R., Tamura, R. (eds) Engineering Crystallography: From Molecule to Crystal to Functional Form. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1117-1_29

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