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Overview of Orchestration of CD4+ T Cell Subsets in Immune Responses

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T Helper Cell Differentiation and Their Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 841))

Abstract

Adaptive immunity plays an important role in the host defense of pathogens, among which CD4+ T helper cell takes a major part. The regulation of Th cell differentiation, the function they exerts in immune response, autoimmune diseases, and allergic conditions, has long attracted much attention. Naive CD4+ T cells differentiate into distinct subsets after receiving TCR and costimulation signaling for activation and cytokine signaling to direct their differentiation. In this chapter, we will have a broad overview of all Th cell subsets, including Th1, Th2, Th17, Treg, Tfh, as well as Th9 and Th22.

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  1. State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China

    Bing Sun & Yuan Zhang

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    Bing Sun

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Sun, B., Zhang, Y. (2014). Overview of Orchestration of CD4+ T Cell Subsets in Immune Responses. In: Sun, B. (eds) T Helper Cell Differentiation and Their Function. Advances in Experimental Medicine and Biology, vol 841. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9487-9_1

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