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α2β1 Integrin

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I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins [55, 56]. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules [35, 79, 128]. Extensive analyses have clearly elucidated the α2 I domain structural motifs required for ligand binding, and also defined distinct conformations that lead to inactive, partially active or highly active ligand binding [3, 37, 66, 123, 136, 137, 140]. The mechanisms by which the α2β1 integrin plays a critical role in platelet function and homeostasis have been carefully defined via in vitro and in vivo experiments [76, 104, 117, 125]. Genetic and epidemiologic studies have confirmed human physiology and disease states mediated by this receptor in immunity, cancer, and development [6, 20, 21, 32, 43, 90]. The role of the α2β1 integrin in these multiple complex biologic processes will be discussed in the chapter.

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  1. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Aasakiran Madamanchi, Samuel A. Santoro & Mary M. Zutter

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  2. Samuel A. Santoro
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    Donald Gullberg

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Madamanchi, A., Santoro, S.A., Zutter, M.M. (2014). α2β1 Integrin. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_3

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