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eIF4E Phosphorylation Downstream of MAPK Pathway

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Translation and Its Regulation in Cancer Biology and Medicine

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Abstract

Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5′ mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.

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Acknowledgments

LF is supported by Prostate Cancer Foundation of Australia grants (#YI-0310, #CG1511) and Australian Research Council grant (#DE120100434). EB is supported by a philanthropic grant from the EJ Whitten Foundation. IT is supported by grants from the Canadian Institutes of Health Research (MOP-115195), Terry Fox Research Institute team grant (TFF-116128), The Canada foundation for innovation Leaders Opportunity Fund (CFI-LOF), Fonds de la Recherche en Santé du Québec (FRSQ) and is a recipient of a CIHR New Investigator Salary Award.

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  1. Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia

    Luc Furic & Emma Beardsley

  2. Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Oncology, McGill University, Montreal, QC, Canada

    Ivan Topisirovic

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  1. Luc Furic
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Correspondence to Luc Furic .

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  1. Surgery, McGill University, Montreal, Québec, Canada

    Armen Parsyan

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Furic, L., Beardsley, E., Topisirovic, I. (2014). eIF4E Phosphorylation Downstream of MAPK Pathway. In: Parsyan, A. (eds) Translation and Its Regulation in Cancer Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9078-9_17

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